Neurosteroids Flashcards
1
Q
What is the receptor target for Neurosteroids (endogenous positive allosteric modulators)?
A
- GABAa receptor
2
Q
resulting effect of neurosteroid on GABAa receptor?
A
-rapid induction of general anesthesia
3
Q
what metabolite facilitates Neurosteroid-initiated general anesthesia
A
Progesterone
4
Q
in what cells are neurosteroids produced? what manner do they operate (endocrine/autocrine/paracrine)?
A
- produced in glial cells
- paracrine AND autocrine activity
5
Q
effect of Q241W mutation in TM region of GABAaR A2 subunit on neurosteroid-mediated enhancement?
A
- impairs neurosteroid enhancement
— reduced duration of mIPSC´s in mouse hippocampus compared to Wild type
6
Q
characteristic phenotype of mouse with A2 Q241W mutation
A
- anxiogenic phenotype
– i.e. impaired NSteroid enhancement–> no induction of general anesthesia
7
Q
Role of brexanalone (5alpha3alpha) in treatment of postpartum depression?
A
- reverse the effects of dramatic neurosteroid increase following birth
- reduction of anxiolytic/analgesic properties
