Neurotransmitter P1 & P2

Question 1

What does dopamine start as

Answer 1

tyrosine

Question 2

What monoamine is dopamine

Answer 2

catecholamine

Question 3

What turns tyrosine into l-Dopa (dihydroxyphenyl amine)

Answer 3

tyrosine hydroxylase

Question 4

what turns dopa into dopamine

Answer 4

dopa decarboxylase

Question 5

what works at full potential always

Answer 5

tyrosine hydroxylase

Question 6

Dopa decarboxylase’s more general term

Answer 6

l-aromatic amino acid decarboxylase

Question 7

dopamine can be broken down by what and then what (works vise versa)

Answer 7

MAO & COMT

Question 8

intra and extra neuronal, has two forms A + B

Answer 8

MAO (monoamine oxidase)

Question 9

This form of MAO is more important for dopamine breakdown in human brains

Answer 9

MAO-B

Question 10

extra neuronal only

Answer 10

COMT (catechol-o-methyl-transferase)

Question 11

either dopamine route leads to this, this is also needed to determine how much dopamine is in a persons brain

Answer 11

HVA

Question 12

in the middle of MAO and COMT breakdown

Answer 12

DOPAC and 3 methyltyramine

Question 13

Main dopamine pathways

Answer 13

nigrostriatal, mesolimbic (most important), and mesocortical

Question 14

all of these are slow, g-protein coupled

Answer 14

dopamine receptors

Question 15

result of activation is EPSP due to Na+ inflow

Answer 15

D1-like receptors

Question 16

prevalent in basal ganglia, frontal lobe, and limbic regions

Answer 16

D1 receptors

Question 17

prevalent in hippocampus

Answer 17

D5 receptors

Question 18

result of activation is IPSP due to K+ outflow

Answer 18

D2-like receptors

Question 19

widespread as inhibitory auto receptors on dopamine neurons

Answer 19

D2 short

Question 20

prevalent in hippocampus

Answer 20

D2 long

Question 21

prevalent in nucleus accumbens, l-dopa can’t pass through blood brain barriers

Answer 21

D3 receptors

Question 22

prevalent in frontal lobe

Answer 22

D4

Question 23

Metyrosine inhibits, l-dopa increases

Answer 23

dopamine synthesis

Question 24

reserpine and tetrabenazine block this

Answer 24

dopamine storage

Question 25

amphetamines promote

Answer 25

dopamine release

Question 26

cocaine, methylphenidate (ritalin) block

Answer 26

dopamine reuptake

Question 27

MAO-B and COMT can be blocked

Answer 27

dopamine metabolism

Question 28

many antipsychotics antagonize

Answer 28

blocks dopamine receptors

Question 28

bromocriptine, pergolide, apomorphine, agonize various receptors

Answer 28

stimulate dopamine receptors

Question 29

need a decarboxylase inhibitor for this disease so l-dopa doesn't turn into dopamine and so it can get through blood brain barrier

Answer 29

Parkinsons Disease

Question 30

tolcapone and entacapone

Answer 30

COMT-I

Question 30

l-dopa and carbidopa

Answer 30

sinemet

Question 30

originally used for Parkinsons, FDA approved for treating CCI (doggie dementia)

Answer 30

selegitine and rasagiline

Question 30

What does dopamine need to turn into norepinephrine

Answer 30

Dopamine- B hydroxylase

Question 30

What does Norepinephrine start out as

Answer 30

Dopamine

Question 30

metabolism is same as dopamines

Answer 30

norepinephrine

Question 31

all are also slow, g-protein coupled

Answer 31

norepinephrine receptors

Question 32

a1 is usually excitatory, a2 inhibitory

Answer 32

alpha-adrenergic types

Question 33

widespread as presynaptic autoreceptors on norepinephrine neurons (inhibitory)

Answer 33

a2

Question 34

important in CNS and PNS

Answer 34

a1 and a2

Question 35

usual result of activation is EPSP for norepinephrine receptors

Answer 35

beta-adrenergic types

Question 36

more important in PNS than CNS

Answer 36

B1 B2 B3

Question 37

fusaric acid blocks dopamine-B-hydroxylase

Answer 37

norepinephrine synthesis

Question 38

reserpine blocks

Answer 38

norepinephrine storage

Question 39

amphetamines promote

Answer 39

norepinephrine release

Question 40

same as da and atomoxine and various anti-depressants block

Answer 40

norepinephrine re-uptake

Question 41

MAO-I's promote

Answer 41

norepinephrine metabolism

Question 42

alpha and beta blockers

Answer 42

block norepinephrine receptors

Question 43

clonodine and xylazine act on a2 autoreceptors

Answer 43

stimulates norepinephrine receptors

Question 44

what does serotonin start as

Answer 44

tryptophan

Question 45

what does tryptophan need to turn into 5-hydroxy-tryptophan

Answer 45

tryptophan hydroxylase

Question 46

5-HT is not a catecholamine, but

Answer 46

an indolamine

Question 47

what does 5-hydroxy-tryptophan need to turn into serotonin

Answer 47

dopa decarboxylase

Question 48

acted on mainly by MAO-A followed by AD, to produce 5-HIAA

Answer 48

5-HT metabolism

Question 49

serotonin is not acted on by this due to it being an indolamine

Answer 49

COMT