Neurotransmitter Receptors & Pharmacology Flashcards Preview

Physiology Exam 5 > Neurotransmitter Receptors & Pharmacology > Flashcards

Flashcards in Neurotransmitter Receptors & Pharmacology Deck (20):
1

3 sites of cholinergic receptors

1. Autonomic ganglionic
2. Parasympathetic postganglionic
3. Neuromuscular junction

2

Cholinergic receptor at autonomic ganglionic

Nicotinic N(G)

3

Parasympathetic postganglionic cholinergic receptor

Muscarinic M(2)

4

Cholinergic receptor at neuromuscular junction

Nicotinic N(M)

5

What does belladona target?

Parasympathetic postganglionic muscarinic M(2)

6

Examples of nicotinic cholinergic ligands

1. ACh
2. Hexamethonium
3. Decamethonium
4. Succinylcholine

7

Hexamethonium is?

Ganlionic antagonist (N(G))→ non-depolarizing blocker

8

Decamethonium is?

Neuromuscular (N(M)) → depolarizing blocker

9

How does agonist binding activate receptor?

Induces conformational shift (picture lock and key)

10

2 major types of metabotropic Nt receptors

1. G-protein linked
2. Tyrosine kinase linked

11

Examples of G-protein linked receptors

1. Beta-adrenergic
2. M(2) muscarinic
3. alpha(1)-adrenergic
4. H(1) histaminergic

12

Receptor associated with G(s)/cAMP pathway

beta-adrenergic

13

Receptor associated with G(i)/cAMP pathway

M(2) muscarinic

14

Receptor associated with G(q)/IP(3)/DAG pathway

alpha(1)-adrenergic

15

Receptor associated with G(q)/NO/cGMP pathway

H(1) histaminergic

16

2 examples of tyrosine kinase linked receptors

Dopamine and NMDA receptor modulation

17

How do non-covalent bonds relate to the "lock and key model"?

Agonists will occupy all important non-covalent bond sites to induce change

18

Beta(2)-adrenergic receptors are found on what organ?

Bronchi

19

Beta(1)-adrenergic receptors are found on what organ?

Heart

20

Atenolol

Blocks beta(1) → selective antagonist