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Neuro U3 > Neurotransmitters Lec 7 > Flashcards

Neurotransmitters Lec 7 Flashcards

(56 cards)

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1
Q

Iontoropic NT receptors

A

Ligand-gated ion channels

4-5 subunits that each contain 3 or 4 transmembrane domains

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2
Q

Metabotropic NT receptors

A

G-protein-couple receptors

Monomeric proteins containing 7 transmembrane domains

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3
Q

Acetylcholine

A

PNS-NMJ

CNS-interneurons in brainstem/forebrain- involved in AD

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4
Q

ACh precursor

A

Acetyl CoA and Choline

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5
Q

ACh removal

A

Acetylcholinesterase

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6
Q

ACh organophosphates- insecticides and sarin

A

inhibit Acetylcholinesterase

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7
Q

ACh receptors

A

Ionotropic/nicotinic- excitatory
Metabotropic/muscarinic- brain and peripheral ganglia
- mediate responses of autonomic effector organs

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8
Q

ACh useful therapeutics

A

Atropine- antagonists- pupil dilation

Scopolamine- motion sickness

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9
Q

Myasthenia Gravis

A

Autoimmune Dz- against nAchR
increased turnover of receptors
muscle fatigue

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10
Q

Glutamate

A

Excitatory in brain

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11
Q

Excitotoxcity

A

High EC concentrations toxic to neurons

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12
Q

Glu precursor

A

Glutamine

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13
Q

Glu removal

A

Reuptake into terminal and glia

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14
Q

Glu receptors

A

Ionotropic- NMDA, AMPA, Kainite

Metabotropic- increase or decrease excitability of postsynaptic cell

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15
Q

GABA

A

Major inhibitory transmitter in CNS

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16
Q

GABA precursor

A

Glutamate

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17
Q

GABA removal

A

Reuptake into terminal and glia

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18
Q

Decreased GABA

A

can cause epilepsy

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19
Q

GABA receptors

A

Ionotropic- GABAa and GABAc

  • open inhibitory Cl channels
  • Benzodazepines and barbiturates

Metabotropic- GABAb

  • in Brain
  • produces inhibitory postsynaptic response
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20
Q

Glycine

A

Spinal cord

inhibitory

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21
Q

Gly precursor

A

Serine

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22
Q

Gly removal

A

Reuptake into terminal and glia

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23
Q

Gly Excess

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A

Neonatal dz characterized by lethargy and MR

24
Q

Gly Receptors

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A

Ionotropic only- open inhibitory Cl channels

25
Strychnine
Blocks Gly receptors | causes overactivity leading to seizures
26
Dopamine
Catecholamine | found mostly in corpus striatum
27
Dopamine fxn
``` Coordination of body movement motivation reward reinforcement emotional behavior ```
28
Dopamine precursor
Tyrosine
29
Dopamine packaging
Vesicular monoamine transporter (VMAT)
30
Synthesis
Tyrosine-DOPA-Dopamine
31
Dopamine receptor
Metabotropic
32
Dopamine removal
Re-uptake into terminal
33
Parkinson Dz
Treated with L-DOPA to increase dopamine levels in striatum
34
Additive drugs
raise dopamine levels by interfering with reuptake
35
Amphetamine
inhibits both dopamine and NE transporters causing net increase in release of transmitters
36
NE
Catecholamine CNS- wakefulness, attention, feeding behavior PNS- Sympathetic motor system
37
NE precursor
Tyrosine
38
NE packaging
Vesicular monoamine transporter (VMAT)
39
NE synthesis
Tyrosine-DOPA-Dopamine-NE-Epi
40
NE receptor
Metabotropic
41
NE removal
reuptake into terminal
42
NE uses
Amphetamine anti-anxiety drugs anti-depressants
43
Serotonin
Regulation of sleep, eating, wakefulness and arousal
44
Serotonin precursor
Tryptophan
45
Serotonin Synthesis
Tryptophan- 5hydroxytryptophan- serotonin
46
Serotonin receptors
Metabotropic- impaired in many psychiatric disorders | Ionotropic- minor one
47
Serotonin removal
Specific serotonin transporter (SERT)- into terminal
48
Serotonin uses
Anti-anxiety | anti-depressants
49
Neuropeptides
Emotions, perception of pain, responses to stress
50
Neuropeptide categories
Brain-gut Opiod Pituitary hypothalamic-releasing
51
Neuropeptide precursor
Amino acids in ER
52
Neuropeptide receptors
metabotropic
53
Neuropeptide removal
peptidases
54
Anti-psychotic drugs
Block dopamine receptors
55
Anti-anxiety drugs
MAO inhibitors block breakdown of biogenic amines | inhibitors of serotonin reuptake
56
Anti-depressants
MAO inhibitors block breakdown of biogenic amines Tricyclic block reuptake of NE and 5HT Serotonin reuptake inhibitors(Prozac) act on serotonin transporters

Neuro U3 (17 decks)

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