NHPs Flashcards
(17 cards)
Saw Palmetto + BPH
- from active part of plant
- works as a non-competitive 5 alpha reductases inhibitor
— well tolerated
CI: pregnancy + lactation
May increase risk of bleeding if on
anticoag
ASRs: reduced libido, hypo , headache, GI upset
safe but possible ineffective
Pygeum + BPH
Likely effective + could even recommend
— works as an anti-proliferation effects (suppress EGF)
studies: improvement in symptoms
little safety concerns
Beta sitosterol (plant cholesterol) + BPH
Normally used for dyslipidemia (found in some foods but at low levels)
MoA: inhibit 5alpha reductase + prostate cell proliferation
Efficacy: showed some decrease in symptoms
well tolerated
likely effective + could even recommend
Lycopene + BPH /prostate health
Found in tomato plants
- though to stop cancer cell growth
—- epidemiological studies showed increase intake —- decrease in prostate incidence (no RCT support, little benefit for BPH)
May be effective for prostate cancer
not enough evidence for BPH
T or F: Selenium can help with prostate health
F- possibly ineffective + discourage use
— people thought lower levels in toenails —- increase prostate risk (observational )
Trial : showed no benefit/ no reduction in cancer
Safety: ok if don’t go over UL (400mcg) — a lot of bad SEs
T or F: Yohimbe bark extract is a great option for ED
F- WATCH OUT
- not good safety profile (HTN, change mental state), MI, afib, seizure
—- a lot of DIs: CNS stimulants, BP meds
Is Yohimbe bark extract approved in Canada ?
NO
— possibly unsafe + discourage use
What is the best option for someone with BPH + high cholesterol
Beta-sitosterol
What can ginseng be used for
DM - increase insulin sensitivity + decrease R (accepts + maybe recommend)
— well tolerated: insomnia in main ADRs
avoid with warfarin
Psyllium
Though to helps with DM (slow carb A, reduce PP glucose)
- some trials show reduce in FBG + A1C
Ses: GI—- bloating, diarrhea, pain
accept + maybe recommend
Which NHPs for BPH may work ?
Beta-sitosterol: also help with cholesterol
Pygeum
Which NHPs may help with prostate cancer
Lycopene
—- ineffective for BPH
Which NPH doesn’t help reduce risk of prostate cancer
Selenium
Why is Saw Palmetto not a great option for BPH treatment
A lot of interactions + RF with use (not great safety profile)
—- most likely not effective too
T or F: Pygeum helps improve symptoms of BPH
T
What is ginseng shown to improve
PP glucose, FPG and A1c
What does psyllium improve
reduce FPG + improves A1c
