Nicotinic receptor antagonists (general) and succinylcholine Flashcards Preview

07 Acetylcholine receptor antagonists > Nicotinic receptor antagonists (general) and succinylcholine > Flashcards

Flashcards in Nicotinic receptor antagonists (general) and succinylcholine Deck (12)
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1
Q

Nicotinic receptor antagonists (2 groups)

A

Ganglionic blocking agents (no longer used).

Neuromuscular blocking agents

2
Q

Neuromuscular blocking agents are also known as…

A

Paralytics

Muscle relaxants

3
Q

Neuromuscular blocking agents (2 groups)

A

Nondepolarizing neuromuscular blocking agents.

Depolarizing neuromuscular blocking agents.

4
Q

Why are the muscle relaxants “extremely dangerous compounds”?

A

May produce complete respiratory failure

5
Q

Paralytics - adverse effects

A

Anesthesia awareness.

Complete respiratory failure.

6
Q

Depolarizing neuromuscular blocking agents (1 drug)

A

Succinylcholine

7
Q

Succinylcholine - MOA

A

Binds to nicotinic receptors in skeletal muscle and causes persistent depolarization of the motor end plate. Initially it causes transient fasciculations, and then sustained muscle paralysis.

8
Q

How can the effect of succinylcholine be reversed?

A

It cannot be reversed, no antidote for overdose exists. However it is broken down by cholinesterase, and has a short duration of action (5-10 min).

9
Q

Succinylcholine - indications

A

Before and during surgery (muscle relaxant).

Facilitate intubation.

10
Q

Preferred neuromuscular blocker for adults with emergency airway situations

A

Succinylcholine

11
Q

Succinylcholine - cautions and contraindications

A

Pts with atypical cholinesterase.
Unhealed skeletal muscle injury and third-degree burns (hyperkalemia).
Conditions involving muscle weakness (hyperkalemia due to up-regulation of ACh receptors).
Children (more susceptible to consequence of hyperkalemia)

12
Q

Succinylcholine - adverse effects

A

Hyperkalemia and cardiac arrest.
Postoperative myalgia (neck, back, abdomen).
Malignant hyperthermia.