NMP MICHELLE Flashcards
What is absorption
Before takes effect it has to be absorbed into the body systems
Main factor relating to this is the route of administration
What factors affect absorption
Route of administration
Physiological considerations- blood flow, total surface area, time of arrival of the drug
Chemical factors - solubility, chemical stability, how soluble it is in lipids
What is distribution
Where the drug is distributed to the bodily fluids
Uptake into organs and tissues
the extent that the drug binds to plasma proteins
passage through the barriers
What is bio-transformation?
The process of metabolising the drug and mainly occurs in the liver
What are pro drugs
Where the drug is inactive until it is metabolises by the liver and becomes active
What is excretion
Renal and faecal elimination
The main method is by active glomerular filtration
What are the sites of dug action
Receptors
Ion channels
Enzymes
Transport systems
What is drug affinity
This is s measure of how well the drug can bind to it’s chemical target.
What is a agnostic drug action
Activates receptors to produce a response
What is an antagonist drug action
Binds with receptors but do not activate them or cause a response
What are receptors
It controls what moves in and out of the cell
What is an ion channel
Provide receptors which drugs can interact with
What is an enzyme
Increases the rate of chemical reactions in the body
What is a transport system
Opposite to diffusion and osmosis, and works against the concentration gradient
What is drug action controlled by
Route of administration
Rate of absorption
Manner if distribution
