Non-Benzo Hypnotics Flashcards Preview

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Flashcards in Non-Benzo Hypnotics Deck (9)
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0
Q

MOA of the non benzo hypnotic?

A

Selective receptor binding to BNZ receptor 1, which is responsible for sedation

1
Q

What are three non-benzo hypnotics usually used for sleep?

A
  1. Zolpidem
  2. Zaleplon
  3. Eszopiclone
2
Q

What is the indication to use zolpidem, zaleplon or eszoplicone?

A

Short term use as sleep aid. Not as much issue with tolerance/dependance, but can still happen.

3
Q

Order of half-life from shortest to longest

A

Zaleplon < Zolpidem < eszopiclone

4
Q

4 side effects of the non benzo drugs?

A
  1. anterograde amnesia
  2. hallucinations
  3. sleepwalking
  4. GI side effects (most common)
5
Q

What is the MOA of Ramelteon? Benefit of using?

A

selective melatonin MT1 and MT2 agonist

*no tolerance or dependence

6
Q

What is MOA of buspirone?

A

partial agonist of the 5HT-1A receptor

*does not potentiate the CNS effects of alcohol so is safe for alcoholics; also not as high risk for abuse as benzos, but takes 1-2 weeks to work

7
Q

What drug is buspirone given with commonly for anxiety and why?

A

Not as effective, so often used with SSRI

8
Q

Other than buspirone, what would be a good anti-anxiolytic to give someone that cant take benzos?

A

Hydroxyzine - is an anthistamine and has anticholinergic effects