Non-Heme

Question 1

t(7;17)

Answer 1

JAZF1 and JJAZ1

Low Grade endometrial stromal sarcoma

Question 2

t(X;18)

Answer 2

SYT and SSX1

Synovial sarcoma

Question 3

t(X;17)

Answer 3

TEF3 and ASPL

Alveolar soft part sarcoma

Question 4

t(2;13)

Answer 4

PAX3 FOXO1

Alveolar RMS
more common

Question 5

t(1;13)

Answer 5

PAX7 FOXO1

Alveolar RMS
less common

Question 6

t(11;22)

Answer 6

EWS-WT1
Desmoplastic small round cell tumor

EWS-FLI1
ES

Question 7

t(12;16)

Answer 7

DDIT3 (CHOP)-FUS

Myxoid liposarcoma

Question 8

t(7;16)

Answer 8

FUS-CREB3L2

Low grade fibromyxoid sarcoma

Question 9

t(15;19)

t(9;15)

Answer 9

BRD4 (or BRD3)-NUT

NUT midline carcinoma

Question 10

t(12;22)

Answer 10

EWSR1-ATF1

Clear cell sarcoma

Question 11

t(10;17)

Answer 11

YWHAE-FAM22

High-grade endometrial stromal sarcoma
Cyclin D1 Positive by IHC (esp in the round cell component)
CD117 Pos by IHC but no Ckit mutation

Question 12

t(11;19)

Answer 12

MECT1 (CTRC1)-MAML2

Mucoepidermoid carcinoma

Question 13

13q14 loss

Answer 13

RB locus

Hereditary retinoblastoma and a 500 times greater risk of osteosarcoma

Question 14

t(9;22)

Answer 14

EWS-NR4A3

Extraskeletal myxoid chondrosarcoma (ESMC)

Question 15

t(1;3)

Answer 15

WWTR1-CAMTA1

Epithelioid Hemangioendothelioma (EHE)