Non Insulin DM Medications

Question 1

Which classes of Non-insulin drugs are insulin sensitizers?

Answer 1

AMPK activators and Thiazolidinediones

Question 2

Patients lose sensitivity to this drug after constant use

Answer 2

K+ATP channel modulators

Question 3

Which K+ATP channel modulator closely mimics natural insulin secretion patterns?

Answer 3

Nateglinide

Question 4

Glucophage is an example of a

Answer 4

AMPK activator or biguanide

Question 5

Which medications can be used in pre-diabetic people?

Answer 5

Thiazolidinediones and Alpha glucosidase inhibitors

Question 6

Which drugs cause weight gain?

Answer 6

K+ATP channel modulators, thiazolidinediones

Question 7

Sulfonylureas MOA

Answer 7

stimulation of insulin release by binding to a specific site on the channel and inhibiting its activity

Question 8

Meglitinides MOA

Answer 8

same as sulfonylureas but bind to different site

Question 9

Metformin MOA

Answer 9

AMPK activator; increases activity of AMP-dependent protein kinase

Question 10

Thiazolidinediones/ glitazones MOA

Answer 10

decrease insulin resistance; regulation of genes involved in glucose and lipids metabolism; ligands of peroxisome proliferator-activated receptor gamma (PPAR-y)

Question 11

How long does it take for glitazones to start working?

Answer 11

4-12 weeks

Question 12

Alpha glucosidase MOA

Answer 12

reduction of intestinal absorption of starch, dextrin, and disaccharides

Question 13

Which drugs can be used as monotherapy?

Answer 13

Rosiglitazone and Alpha-glucosidase

Question 14

GLP MOA

Answer 14

bind to receptors in B cells (stimulate cAMP production and Ca2+ influx= more insulin release)
Hypothalamus= reduce food uptake

Question 15

GLP-1 Agonist MOA

Answer 15

bind to the GLP-1 receptor and increase insulin biosynthesis and increased insulin release after meals