Non-malignant breast disease Flashcards

(51 cards)

1
Q

What is acute pyogenic mastitis?

A

Painful acute inflammatory condition of the lactigerous duct which usually occurs weeks after delivery.

S. aureus is the most common cause (transmitted y infant during lactation).

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2
Q

How do organisms get into the breast tissue to cause acute pygenic mastitis?

A

A crack in the nipple - infection is usually confined to one segment of the breast

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3
Q

What can occur as a complication of acute pygenic mastitis?

A

Breast abscess

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4
Q

How do breast abscesses present?

A

Painful, hot swelling of breast segment. Erythema and tenderness wtih palpable lump.

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5
Q

How would you manage someone with a breast abscess?

A
  • Antibiotics
  • Repeated US guided drainage as often as needed
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6
Q

What is ductal ectasia?

A

Condition in which the lactiferous duct becomes blocked or clogged.

The ducts are dilated and filled with white–green viscid matter, which may be discharged from the nipple.

If bloodstained, this can be mistaken for carcinoma, but there is no relationship to malignancy.

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7
Q

When in a womans life does ductal most commonly occur?

A

During menopause - normal changes where ducts dilate with age.

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8
Q

How does someone with ductal ectasia present?

A
  • Nipple discharge - green/brown/can be bloody “cheesy”
  • Nipple retraction - due to eventual duct fibrosis
  • Lump

May also present with microcalcification on routine mamogram.

Non cyclical mastalgia.

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9
Q

How would you manage someone with ductal ectasia?

A
  • Refer for diagnosis
  • No treatment normally needed
  • Advise to stop smoking
  • Exision of duct in persistant/recurrent cases
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10
Q

What would you advise someone with ductal ectasia to stop doing?

A

Smoking

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11
Q

What is fat necrosis?

A

Fibrosis and calcification after trauma to the breast eg seatbelt injury/prior surgical intervetnion.

Macroscopically, the tissue is yellow and haemorrhagic, with flecks of calcification.

Fibrous tissue is also present, the amount depending on the duration of the condition.

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12
Q

How do those with fat necrosis of the breast present?

A
  • Firm lump (painful/painless)
  • History of trauma

(Can mimic carcinoma clinically and mammographically)

More likely to occur in overweight women.

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13
Q

How would you manage someone with fat necrosis of the breast?

A
  • Refer for triple assessment
  • No treatment once diagnosis confirmed - usually resolves spontaneously
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14
Q

What is gynaecomastia?

A

Gynaecomastia is benign enlargement of the male breast tissue. The breast may resemble that of a young adolescent female in appearance and consistency, or there may be a firm, mobile disc beneath the nipple

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15
Q

What is a fibroadenoma?

A

Commonest type of primary benign tumour which arises from overgrowth of collagenous mesenchyme of one breast lobule.

They involve proliferation of both the connective tissue stroma and the glands.

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16
Q

Peak incidence fibroadeoma

A

20-24 years

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17
Q

How do fibroadenomas present?

A

Firm, smooth, painless, well-circumscribed mobile lump in the breast

May be multiple

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18
Q

How would you manage someone with a fibroadenoma?

A
  • Observation and reassurance
  • Refer for USS +/- FNA - if unsure
  • Consider surgery if large (>3cm)
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19
Q

Does a fibroadenoma progress to malignancy?

A

No

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20
Q

When do fibroadenomas tend to present?

A

<30 yrs

Partially hormone regulated so may regress after menopause

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21
Q

What is a duct papilloma?

A

Commonest cause of discharge

Arise from solitary lesion within a large duct. They consist of branching fibrvascular cores covered by epithelium.

Are a wart like growth that sits just behind areaolar

22
Q

Presentation of duct papilloma

A

Nipple discharge

Mass feels elongated 0 along lumen of duct

23
Q

Management duct papilloma

A

Microdeochectomy - excision of duct

24
Q

What is the commonest cause of a mobiile lump?

25
What is the commonest cause of ill-defined lump or lumpy areas?
Fibrocystic changes
26
What is the commonest cause of clear nipple discharge?
Duct ectasia
27
When do breast cysts occur most commonly?
Perimenopause
28
How do breast cysts present?
* **Benign, fluid filled rounded lump** * **Can be painful** - worse during second half of menstrual cycle * **Not fixed to surrounding tissues so is mobile** * **Red, hot, tender swelling** Commonly in those aged 40-45
29
Management of breast cyst
Aspiration nd cytology if bloody fluid suggestive of malignancy Aspiration and reassurance Can commonly recurr, slight increased risk of breast cancer.
30
What is the most commonly implicated organism in a breast abscess?
Staph aureus
31
What investigation would you do if you suspected a breast abscess?
Breast USS
32
What could a breast abscess be linked with in elderly women?
Could be part of mammary duct ectasia
33
Typical cause of cyclical mastalgia?
Occurs in response to hormonal changes of menstrual changes Pain from mid-cycle to menstruation Breast heaviness and lumpiness Consider fibradenosis
34
Typical causes of non cyclincal breast pain?
* Mastitis * Trauma * Inflammatory breast cancer * Duct ectasia * Drugs (HRT, antidepressants, spironolactone, digoxin)
35
How would you manage mastalgia?
* **Analgesia - paracetamol, NSAIDs** * **Primrose oil/Starflower oil - GAMELONIC ACID** (few SEs) * **Continuous/severe** - Low dose Danazol or Bromocriptine
36
What referred pain could cause mastalgia?
* Arthritis or chest wall * Lung disease * Angina * Gallstones * Others - HRT
37
What would be your differential diagnosis for the following?
* **Eczema** * **Psoriasis** * **Dermatitis** * **Paget's disease**
38
How would you investigate the following?
* **Punch biopsy** * **Mammogram** * **Consider triple investigation**
39
How would you investigate nipple retraction?
Mammogram and USS
40
How would you investigate Nipple discharge?
* **Clinical exam** * **Mammogram** * **USS** * **Discharge cytology**
41
What would pussy nipple discharge indicate?
Infection
42
What might milky nipple diuscharge indicate?
* **Pregnancy** * **Prolactinoma** * **Post-pregnancy**
43
What might bloody nipple discharge indicate?
Intraduct papilloma/malignancy
44
What might toothpaste-like nipple discharge indicate as a cause?
Duct ectasia
45
What are causes of gynaecomastia?
* **G**enetic/**G**ender disorder (Klinefelter) * **Y**oung boy (pubertal)\* * **N**eonate\* * **E**strogen * **C**irrhosis/ **C**imetidine/ **C**a Channel blockers * **O**ld age\* * **M**arijuana * **A**lcoholism * **S**pironolactone * **T**umors (Testicular & adrenal) * **I**soniazid/ **I**nhibition of testosterone * **A**ntineoplastics (Alkylating Agents)/ **A**ntifungal(ketoconazole)
46
What drugs can cause gynaecomastia?
* **S** = Spironolactone * **A** = Alcohol * **C** = Cimetidine * **K** = Ketocanazole * **E** = Estrogen * **D** = Digitalis, digoxin
47
What is phyllodes tumour
Tumour of fibro-epithelial stroma (majority benign)
48
Presentation of phyodelles tumour
Firm lump that is fast growing. Large masses. Commonest in women aged between 40-50 who haven't yet been through menopause.
49
What is seen on imaging of phyllodes tumour?
Leaf like appearance
50
Management of phyllodes tumour
Wide excision - can be benign, borderline, malignant. Follow up needed due to risk of recurrence. Mastectomy for large tumours.
51
Briefly discuss the following: * Fibroadenoma * Breast abscess * Fat necrosis * Intraduct papilloma * Duct ectasia
* Fibroadeoma: * Firm, smooth, well circumscribed mobile limb (non tender) * Breast abscess * Pain wrose second half of menstrual cycle * Fat necrosis * Firm localised lump (trauma associated) * Need to exclude carcinoma * Intraduct papilloma * Blood stained nipple discharge * Duct ectasia * Green, brown, bloody "cheese" secretions