Non-Opioid Analgesic doses Flashcards Preview

Pharm 512 Drugs > Non-Opioid Analgesic doses > Flashcards

Flashcards in Non-Opioid Analgesic doses Deck (23):
1

What is the dose for Tylenol?


650-1000 mg IV q 4-6hr

2

What is Tylenols MOA?


Unclear, possibly COX-2 inhibitor within CNS, inhibits prostaglandin synthesis

3

What are the anesthetic indications for Tylenol?

Anesthesia concerns: Monitor BP. Do not exceed max daily dose (<2g/day) d/t hepatic enzyme induction and impaired glucuronidation

4

What is the half-life of Tylenol?

1-3 hours

5

What are side effects/contraindications of Tylenol?

N/V, HA, insomnia; Hepatotoxic

6

What is Ibuprofens MOA?

COX-1 & COX-2 inhibitor; antipyretic, anti-inflammatory, & analgesic

7

What are the anesthetic concerns for Ibuprofen?

Anesthesia concerns: Increased concern w/ pts at risk for renal dysfunction, altered platelet fxn, and GI irritation. Monitor BP. May increase fluid accumulation/edema in CHF pts.

8

What is the dose for Ibuprofen?

400-800 mg IV q 6hr

9

What are side effects/contraindications of Ibuprofen?

Dizziness, epigastric pain, rash, tinnitus, renal dysfunction

10

What is the half-life of Ibuprofen?

2.2-2.4 hr

11

What is Ketorolac's MOA?

COX-1 & COX-2 inhibitor

12

What is Ketorolac's dose?


30 mg IM
15 mg or 30 mg IV Q6H
(Not to exceed 120mg in 24hrs)

13

What are the anesthetic concerns for Ketorolac?

Anesthesia concerns: PDA closure when given peripartum, renal toxicity in pts with renal diseases, bleeding risk.

14

What is the half-life of Ketorolac?

2-6 hr

15

What are the side-effects/contraindications of Ketorolac?

Dyspepsia, HA, GI pain, nausea, somnolence, renal dysfxn

16

What is the MOA of Celebrex?

COX-2 inhibitor

17

What is the dose of Celebrex?

200 mg PO daily or divided BID

18

What are the anesthetic concerns for Celebrex?

Anesthesia concerns: Does NOT inhibit platelets or prolong bleeding time.

19

What is the half-life of Celebrex?

11 hr

20

What are the side-effects/contraindications of Celebrex?

HTN, HA, fever, dyspepsia, URI, ↑risk of MI/CVA, fluid retention, renal injury; avoid in sulfa/ASA allergies

21

What is the MOA for ASA?

Irreversible Non-selective COX inhibitor

22

What is the dose for ASA?

81 mg for anti-thrombotic treatment

23

What are the indications for ASA?

Decrease fever, Anti-platelet effects