Non-Opoids Flashcards by JT JT

What is the trade name for acetylsalicylic acid (ASA)

What type of drug is it

Aspirin

NSAID (different chm than normal)

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What is the mechanism of acetylsalicylic acid

Cox 1/2 inhib

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When is the indications of aspirin

MI (emergency kit)

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What are the contraindications of aspirin

Viral pts esp in kids, gout, GERD, hernia, asthma, anticoagulants, chronic gastritis, third trimester (prolonged labor, hemmorhage, premature duct closing.) Methotrexate

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What should you prescribe instead of Methotrexate with aspirin

acetomin

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What are the side effects of Salicylism-

confusion, tinnitus, dizziness, nassau, vomiting

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What are the possible cross reactions with aspirin

other NSAIDS Blocks clearance of methotrexate (for autoimmune and chemotherapy

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What other adverse effects come from asprin

Salicylism- confusion tinnitus, dizziness, naseau, vomitting

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A patient with cardiac stents should be taken off of what but not Asprin

Plavix

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True or false, Older patients need to come off of aspirin for dental work

False

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What is the mechanism for general NSAIDS

COX inhibitor

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What are the indications for a need of NSAIDS

pain fever inflammation

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What are the contraindications for NSAIDS

advanced renal disease, with ibuprofen, kidney or liver issues

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What are the side effects of NSAIDS

CNS, skin reactions (cross-sens with aspirin)

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What cross reactions can occur when taking taken with alcohol and smoking

Bleeding

Blocks exertion of lithium

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True or false, NSAIDS cause MI/stroke, hypotension, nephropathy, and Steven-Johnson syndrome

FALSE HYPERTENSION

What is the mechanism for ibuprofen

It blocks cox 1 and 2

What is a contraindication for ibuprofen

Methatrexate script acetomin instead

Methotrexate when taken with ibuprofen can cause what type of cross reaction

Interfere with the platelet effect of ibuprofen

Naproxen or Aleve Anaprox or Naprosyn uses what type of mechanism and is what type of drug

Cox 1 and 2 blocker and NSAID

Aleve is though to not work very well, what is important while taking aleve

It works much better if you don’t neglect the loading dose

What is the max dose for ibeprophen

`1200 mg (gi and kidney complications above that amount.

What is the optimal analgesia

400mg higher is for the antiinflamatory

What is an example of a selective NSAID

celecoxib or Celebrex, its a special NSAID

What is the mechanism for celcoxib or Celebrex

Blocks Cox 2

What is a drug that works well specifically on arthritis pain and is approved for dentistry

Celecoxib Celebrex, great for analgesia

True or false,Pregnancy is a contraindications for Celecoxib or Celebrex

True

What is a side effect of Celezoxib

still have bleeding issues should be different mechanism than cox 1 and 2 inhibs

What other adverse effects come with taking Celexoxib or celebrex

Strokes and heart attacks all other COX 2 inhibits were pulled for this reason

Celebrex chronic use can delay what

Alzheimers , also benefits for cancer

Acetaminophen/Tylenol is characterized as what type of drug

Misc analgesic

What is the mechanism for acetaminophen

Blocks COX 3, used for analgesia, antipyresis NOT antinflamamation

True or false acetaminophen is a great anti-inflammatory drug

FALSE IT IS NOT

What problems can occur from taking acetaminophen

Liver disease/dysfunction HX of alcoholism

What should not be taken with acetaminophen and what can happen

Coumadin, can increase bleeding time 10x, also increased risk for NSAIDS but acetomin better for short term analgesia

True or false acetaminophen causes brochoconstriction

False

True or false acetaminophen can platelet inhibition, irritate GI

False NSAIDS and aspirin cause these thing

Tylenol dropped their upper limit because of what

High presence of liver disease in the US