Noncompartmental Analysis PK

Question 1

What are the variables involved in noncompartmental analysis?

Answer 1

AUC, AUMC, MRT, CL, Vdss

CL= Dose/AUCiv

Question 2

What is the MRT?

Answer 2

Mean Residence Time
* MRT of drug X would mean the average time one drug molecule
spends in the body from dosing to elimination

Question 3

How do we find AUC using the trapezoid rule?

Answer 3

AUC= (Cpn+ Cpn+1)/2 x (tn+1-tn)

Question 4

What rate constant do we use for the AUC and AUMC calcs?

Answer 4

The terminal phase elimination rate constant
- Kel

Question 5

How do we estimate AUC and AUMC after IV administration?

Answer 5

• AUC and AUMC can be estimated regardless of peak shapes
• MRT and CL can be estimated

Question 6

What is the major phase concept?

Answer 6

The approximation of multi-compt to one-compt for various clinical applications

Question 7

What is the superposition principle?

Answer 7

After multiple doses, AUCss,0-t=AUCsingle dose, 0-infinity, irrespective of peak shapes

Question 8

What are the advantages of noncompartmental analysis?

Answer 8

Minimal number of assumptions (minimizes bias)

Will work for many types of data (descriptive)

Can compare across datasets/drugs

Limited in information about secondary processes

No assumptions about distribution into body or segmented processes in the
body (holistic)

Poor relating to specific organ function

Sometimes, favored approach due to lack of assumptions

Question 9

What are the advantages of compartmental analysis?

Answer 9

Fits data for a specific case

Better accounts for biological processes

Provides better insight into the “fate of drug”

Driven by data and by assumptions

Compatibility to predict conc for certain time point