Normal and Abnormal Breast Exam Flashcards

(50 cards)

1
Q

Where does most of the glandular tissue exist in the female breast?

A

The upper outer quadrants

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2
Q

What are the 2 most common routes for metastasis in the breast?

A

Ipsilateral lymph node and Internal mammary nodes

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3
Q

What are the 4 congenital anomalies of the breast?

A

Absence of the breast

Accessory breast tissue along the milk line

Extra nipples (polythelia)

Accessory breast (polymastia)

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4
Q

What are the 2 most common breast complaints?

A

Breast pain and apparent mass

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5
Q

What are 2 risk factors for development of breast cancer (in terms of onset/cessation of menarche/menses)?

A

Early menarche (12> y/o)

Late cessation of menses (>55 y/o)

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6
Q

What are some common risks for breast cancer? (8)

A
Never breast fed
Recent and long-tern use of oral-contraceptives
Post-menopausal obesity
H/O endometrial or ovarian cancer
Alcohol consumption
Increased height
High socioeconomic status
Ashkenazi Jewish heritage
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7
Q

Palpable breast masses always get…

A

A biopsy (FNA/core/excisional)

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8
Q

Mammography is able to detect… (2)

A

Lesions about 2 years before they become palpable

Inapparent masses of <1 cm

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9
Q

At what age is mammography best?

A

> 40 y/o

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10
Q

What is breast ultrasonography most useful in evaluating?

What age group is most appropriate?

A

Inconclusive mammogram findings

Young women (<40 y/o) and others with dense breast tissue

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11
Q

What are 2 unique functions of breast ultrasonography?

A

Allows for differentiation between cystic and solid lesions

Guidance when performing a core needle biopsy

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12
Q

Under which scenarios (3) would a breast MRI be appropriate?

A

In adjunct with mammography for suspicious masses

Post-cancer diagnosis for staging evaluation

Women at risk for breast cancer (BRCA mutations, etc.)

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13
Q

FNAB is useful for:

A

Determining solid vs. cystic masses

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14
Q

What kinds of fluids from FNAB would indicate mammography/US?

A

Bloody fluid should be sent for cytology and followed with mammography/US

Clear fluid does not require further evaluation

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15
Q

What should be done after FNA with cystic masses?

A

Return to clinical breast exam in 4-6 mo. if cyst completely disappears with aspiration

If cyst reappears or does not fully resolve, diagnostic mammogram/US and biopsy are indicated

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16
Q

How many samples are needed in a core biopsy? How big should they be?

A

3-6 samples about 2 cm. long

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17
Q

When does cyclic mastalgia begin and end?

A

It begins at the luteal phase and ends after onset of menses

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18
Q

What is non-cyclic mastalgia?

A

It is not associated with the menstrual cycle and may include tumors, mastitis or cysts or with some medicines

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19
Q

What medications are associated with non-cyclic mastalgia? (3)

A

Anti-depressants

Anti-hypertensives

Hormonal meds (OCPs)

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20
Q

What are 3 extra-mammary causes of mastalgia?

A

Chest wall trauma

Shingles

Fibromyalgia

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21
Q

What is the only FDA approved treatment for mastalgia?

What are its side effects?

A

Danazol

Menstrual irregularities, benign intracranial HTN, changes in blood sugar, deepening of voice, abnormal hair growth, weight gain

22
Q

What 2 drugs may help in mastalgia?

A

Oral contraceptives

Depo Provera

23
Q

What lifestyle modifications may help mastalgia symptoms? (6)

A
Properly fitting bra
Weight loss
Exercise
Decreased caffeine intake
Vit. E supplementation
Evening of primrose oil
24
Q

Nipple discharge is usually _______, but can be a sign of _______ or _______

A

Usually benign, but can be a sign of an endocrine disorder or cancer

25
Non-spontaneous, non-bloody (clear, green or yellow) and bilateral discharge is most consistent with...
Fibrocystic changes or ductal ectasia
26
What could a milky discharge be a sign of? In which patients is it common?
Common with childbearing, but can indicate hyperprolactinemia, hypothyroidism or medication-related response (oral contraceptives or psychotropics)
27
Bloody nipple discharge should be considered...
Cancer until proven otherwise
28
What is on the DDx for bloody nipple discharge? How is it evaluated?
1. Cancer: intraductal carcinoma or ductal carcinoma 2. Benign intraductal papilloma Breast ductography
29
What are the 3 categories of breast masses and what is the RR of developing cancer?
Non-proliferative: 1.0 Proliferative without atypia: 1.5-2.0 Proliferative with atypia: 8.0-10.0
30
What are fibrocystic changes?
A spectrum of changes observed in the normal breast present in about 50% of women: lobules of breast dilate and form cysts and cysts rupture and result in scarring and inflammation
31
What is adenosis?
Lobular growth with increased number of glands
32
What causes lactational adenomas?
A hormonal response
33
What are the most common benign tumor of the female breast?
Fibroadenoma
34
At what age do fibroadenomas develop? What is their gross appearance? How big are they usually? Can they become malignant?
Late teens to early 20s Solid, rubbery, mobile and typically solitary Usually 2-4 cm but can be as big as 15 cm Yes - complex cellular lesions have an increased risk
35
What is a galactocele? When does it occur? What is a complication? What is the treatment?
A cystic dilation of duct filled with milky fluid Occurs near time of lactation Secondary infection that causes acute mastitis Typically can be needle aspirated
36
What is sclerosing adenosis?
Increased fibrosis within the breast lobules
37
What are complex sclerosing lesions (radial scars)?
Tubules trapped within a dense stroma surrounded by radiating arms of epithelium
38
What are papillomas? What ages do they appear? What kind of discharge may result?
Intraductal growths 30-50 y/o Serous or serosanguinous discharge
39
Which 4 lesions are considered "proliferative without atypia"?
Epithelial hyperplasia Sclerosing adenosis Complex sclerosing lesions (radial scars) Papillomas
40
Is Lobular CIS (LCIS) pre-malignant?
No, but it is a risk factor
41
What is Ductal CIS?
Ducts filled with atypical epithelium which is an increased risk for developing invasive disease or reoccurance of DCIS
42
How are LCIS and DCIS treated usually?
Excision and followed with selective estrogen receptor modulators
43
What is the lifetime risk for developing breast cancer vs. the lifetime risk of dying from it?
Developing breast cancer - 1:8 | Lifetime - 1:28
44
What are the risks of developing cancers in women with a BRCA1 and BRCA2 mutation?
BRCA1: 50% of early onset breast cancers and 90% of hereditary ovarian cancers BRCA2: 35% of early onset breast cancers and a lower risk of ovarian cancer
45
In which patients is the Gail model not as useful? In which patients might it be falsely elevated? Women with high risk are counseled to explore what options?
Less useful in second degree relatives with breast cancer Falsely elevated in patients with multiple breast biopsies Women considered high risk (5-year risk of >1.7%) counseled on prophylactic therapy (chemoprevention, mastectomy, oophorectomy)
46
What is the most common to least common types of breast cancer?
1. Ductal (70-80%) - most common in women in 50s and spread to regional LNs 2. Lobular (5-15%) - more likely to be multifocal and/or bilateral 3. Nipple - Paget's disease presenting as superficial skin lesions (3%) 4. Inflammatory breast cancer (1-4%) - swelling, redness and induration of nearby tissue
47
What should be used in addition to staging to determine the prognosis of breast cancers?
Receptor status
48
Which oncogenes signify a worse prognosis? How common is it?
HER2/neu (20-30% of invasive cancers)
49
What therapy is used in all stages of breast cancer?
Adjuvant therapy - reduces reoccurence by 1/3 and reduces risk of death by 30%
50
Breast cancer follow-up schedule for.. First 2 years post diagnosis After first 2 years When do most reoccurences happen?
First 2 years post diagnosis: every 3-6 mo. After first 2 years: annually Within first 5 years after treatment