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Clin 504 > Normal Skin Flora > Flashcards

Normal Skin Flora Flashcards

1
Q

Characteristics of Peptostreptococcus

A

Anaerobic Gram +

Coccus

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2
Q

Diseases caused by Peptostreptococcus

A

URIs
Abscesses formation (tonsillar, abdominal, cerebral)
Necrotizing soft tiss infs
Bone/joint infs

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3
Q

Main Virulence Mechanisms Peptostreptococcus

A

IgG Fc binding activity
antimicrobial resistance
Polymicrobial synergy establishment

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4
Q

Nationally Notifiable

A

…

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5
Q

Characteristics of Aerococcus

A

Gram + coccus

Capnophilic

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6
Q

Diseases caused by Aerococcus

A

….

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7
Q

Main Virulence Mechs of Aerococcus

A

…

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8
Q

Characteristics of Propionibacterium acnes

A 
Anaerobic Gram +
lipophilic rod (lipid lover) --> puberty
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9
Q

Diseases Caused by Propionibacterium acnes

A

Acne

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10
Q

Main Virulence Mechs of Propionibacterium acnes

A 
*Glycocalyx biofilm "glue"
Glycoside hydrolases
B-N-acetylglucosaminidase
Lysophospholipase
*Triacylglycerol lipase
Neuraminidases
Several Proteases
*Development of inflammation inducing strains
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11
Q

Characteristics of Acinetobacter

A

Aerobic
Non motile
Pleomorphic

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12
Q

Characteristics of Bacillus

A

Gram + rod
Aerobic
Form spores
Can be capsulated or not

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13
Q

Virulence mechs of Bacillus

A

Endospore production

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14
Q

Diseases of Bacillus

A 
Endocarditis
Bacteremia
Osteomyelititis
Meningitis
Wound infections
Necrotizing Fasciitits
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15
Q

Characterisitics of Staphylococcus aureus

A 
Fac anaerobic 
Gram +
Clumps of coccus
Beta-hemolytic
Catalase/Coagulase +
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16
Q

Diseases of S. aureus

A

Staph Scalded Skin Syndrome
Toxic Shock Syndrome
Staphylococcal Food Poisoning (enterotoxin-producing strains)

17
Q

Virulence mechs of S. aureus

A

20 diff known adhesions MSCRAMMs: Staph protein A, Fibronectin binding prot A/B (FnbpA, FnbpB), collagen binding protein, clumping factors A and B (Clf)

Exoenzymes: nucleases, proteases, lipases, hyaluronidase, and collagenase

Capsules

18
Q

What are MSCRAMMs?

A

microbial surface components recognizing adhesive matrix molecules) –> anchored in the bac cell wall and function to recognize and bind common moities associated with the ECM of host’s cell/blood plasma

19
Q

Characteristics of Clostridium

A

Gram + rod
Anaerobic
Spore production

20
Q

Diseases of Clostridium

A 
Wound infs
Clostridial myonecrosis (necrotizing faciitis --> if C. perfringens)
21
Q

Virulence mechs of Clostridium

A

Spore production
Stability in deeper tissues (all anearobes!)
Hemolysin production
Collagenase
*Toxins that increase capillary permeability
Capsule

22
Q

Characteristics of Staphylococcus epidermidis

A

Gram + clumps of coccus
Coagulase neg
gamma hemolytic
adapted for life on skin

23
Q

Diseases of S. epidermidis

A

ICU blood infs

Infs from indwelling medical devices

24
Q

Virulence mechs of S. epidermidis

A

Biofilm
*Poly-glutamic acid exopolymer production
MSCRAMMs (fibronectin)
General exoprotease cytolytic enzymes

25
Q

Characteristics of Candida

A

Yeast w/round ovoid cells
“blastoconidia”
Pseudohyphae
2-3x the size of Staph

26
Q

Disease/Inf of Candida

A

Cutaneous candidiasis

Clin 504 (1 decks)

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