Normocytic Anemia Flashcards
(13 cards)
Normocytic Anemia with Low Retic Count
Decreased stimulation of what?
Causes what anemias?
RBC production in bone marrow
Anemia of Chronic disease
Chronic Kidney Disease
Normocytic Anemia with Low Retic Count
Isolated Decrease in RBC precursors causes?
Red cell aplasia
Normocytic Anemia with Low Retic Count
Bone marrow damage is caused by what?
Fibrosis, tumor, infection
Normocytic Anemia with Low Retic Count
Disorder of hematopoiesis
Myelodyplasia
Sideroblastic anemia
Anemia of Chronic disease will show what with the following labs:
Serum Iron
TIBC
% saturation (TSAT)
Ferritin
Cytokine levels
WBC and platelets
erythropoietin level
Reticulocyte count
Reduced-Normal
Reduced-Normal
Reduced
Normal-Increased
Increased
normal
inappropriately low
low
Iron Deficiency Anemia will show what with the following labs:
Serum Iron
TIBC
% saturation (TSAT)
Ferritin
Cytokine levels
WBC and platelets
erythropoietin level
Reticulocyte count
Reduced
Increased
Reduced
Reduced
Normal
normal
inappropriately low
low
Treatment Approach to the Anemia of Chronic Disease
Associated Conditions include?
Malignancy
Chronic infection
Chronic inflammatory state (autoimmune d/o)
Treatment Approach to the Anemia of Chronic Disease
Treatment Options
Underlying condition
RBC transfusions
Erythropoietic Stimulating Agent (ESA) - not usually indicated
Iron supplement - not usually indicated
PO iron supplementation for CKD is considered to be what?
ineffective
What is the primary therapy in anemic patients with non-hemodialysis dependent CKD?
IV iron
IV iron in CKD anemia
Consider in patients with ferritin levels < what? and transferrin levels < what?
Hematopoietic response with rise in Hgb > what?
Approximately 1/3 of patients reached what?
600; 20%
1g/dl
hgb/hct
In hemodialysis-CKD about 1/3 of patients don’t need what after iron?
ESA
ESA therapy Optimization
Target Hgb of what to avoid increased risks such as what? with higher hgb.
10.5-11.5
thrombotic disease
