NSAID and APAP

Question 1

APAP clinical indications

Answer 1

fever

mild/mod pain

Question 2

antidote for APAP OD

Answer 2

acetylcystiene

Question 3

dose of APAP for kids

Answer 3

160mg/5mL

Question 4

dose of APAP for adults

Answer 4

max= 1000mg

Question 5

who gets hepatotoxicity from APAP?

Answer 5

chronic drinkers

Question 6

does ASA help with pain?

Answer 6

no

Question 7

Carboxylic acids

Answer 7

ASA

Question 8

Propionic acids

Answer 8

ibuprofen

naproxen

Question 9

who uses naproxen? why?

Answer 9

adults–longer 1/2 life

Question 10

acetic acid derivatives

Answer 10

diclofenac

ketoralac

Question 11

enolic acid

Answer 11

piroxicam and meloxicam

Question 12

clinical indication for NSAID

Answer 12

inflammation
pain
fever
dysmenorrhea

Question 13

what NSAID is only IM/IV?

Answer 13

ketorolac

Question 14

what form should you use diclofenac in?

Answer 14

topical

Question 15

who should not recieve NSAIDS if possible d/t risk

Answer 15

high GI or high CV risk

Question 16

who should NEVER recieve NSAIDS?

Answer 16

AMI patients

Question 17

what systems is diclofenac toxic to?

Answer 17

cardiac
hepatic
GI

Question 18

labs for NSAID use

Answer 18

CBC; d/t risk of bleed

CMP; d/t renal/liver functions

Question 19

GI ADR from nsaid

Answer 19

dyspepsia
gastritis
PUD–esp if old & on high dose

Question 20

CV ADR from nsaid

Answer 20

thrombosis

Question 21

lowest thrombotic risk nsaid

Answer 21

naproxen

Question 22

highest thrombotic risk nsaid

Answer 22

diclofenac

Question 23

what happens to asthmatics that take aspirin

Answer 23

they can have an exacerbation

Question 24

what do NSAIDS decrease the efficacy of?

Answer 24

ACEI/ARB/diuretic

Question 25

what do NSAIDS increase the conc. of?

Answer 25

Lithium

Question 26

what drug combination can cause AKI in those >65 y/o, or with CKD, or HF?

Answer 26

NSAID + diuretic + ARB

Question 27

how do NSAIDS interact with platelets?

Answer 27

they are anti-platelet

Question 28

if NSAIDS are anti-platelet..what drug should you be careful with?

Answer 28

warfarin

Question 29

what 3 drugs minimize GI effects of NSAIDS?

Answer 29

misoprostol H2RA PPI

Question 30

what NSAID is least GI toxic?

Answer 30

Ketorolac

Question 31

1st line NSAID

Answer 31

ibuprofen/naproxen

Question 32

2nd line NSAID

Answer 32

piroxicam/meloxicam

Question 33

3rd line NSAID

Answer 33

ketorolac

Question 34

4th line NSAID

Answer 34

diclofenac

Question 35

low GI + low CV risk NSAID

Answer 35

Celecoxib

Question 36

low GI risk + high CV risk NSAID

Answer 36

napoxen

Question 37

mod GI risk + low CV risk NSAID

Answer 37

celecoxib

Question 38

mod GI risk + high CV risk NSAID

Answer 38

napoxen + PPI

Question 39

high GI risk + low CV risk NSAID

Answer 39

AVOID NSAID | --if you must celecoxib + PPI or misoprostol

Question 40

high GI risk + high CV risk NSAID

Answer 40

AVOID NSAID

Question 41

what does celecoxib bind to?

Answer 41

cox 2 only

Question 42

does celecoxib bind platelets

Answer 42

NO

Question 43

what is celecoxib used in?

Answer 43

RA/OA/Sponylo/Gout--chronic pain issues

Question 44

ADR of celecoxib that is allergen

Answer 44

sulfa

Question 45

what is celecoxib a substrate of?

Answer 45

2C9

Question 46

what is the reason some Cox 2 inhibitors were removed from the market?

Answer 46

prothrombotic

Question 47

best GI NSAID=

Answer 47

celecoxib

Question 48

best heart NSAID=

Answer 48

naproxen

Question 49

3 muscle relaxants we USE

Answer 49

cyclobenzprine baclofen dantrolene

Question 50

cyclobenzaprine MOA:

Answer 50

identical to amytriptyline | --acts on serotinergic pathways to reduce somatic motor activity

Question 51

cyclobenzaprine clinical indications

Answer 51

msk conditions | SHORT TERM USE

Question 52

muscle relaxant with evidence for efficacy

Answer 52

cyclobenzaprine

Question 53

who shouldn't recieve cyclobenza?

Answer 53

AMI, HF, arrhythmia pts

Question 54

dose for cyclobenzaprine?

Answer 54

5 mg

Question 55

Main ADRs for cyclobenzaprine?

Answer 55

QT prolongation sedation dizziness xerostomia

Question 56

what can you NOT combine cyclobenza with?

Answer 56

CNS depressants MAOI TRAMADOL

Question 57

what is a rare rxn from use of carsoprodol?

Answer 57

transient quadriplegic

Question 58

what is tizanidine similar too? means we do what if we have to discontinue it?

Answer 58

clonidine--MUST taper d/t hypotension

Question 59

Baclofen clinical indications

Answer 59

MS or SC injury

Question 60

Dantrolene clinical indications

Answer 60

Malignant hyperthermia--prevention and management

Question 61

dantrolene has what ADR?

Answer 61

dose-dependent hepatotoxicity