NSAID-induced gastropathy Flashcards
(2 cards)
What is the primary mechanism of NSAID gastropathy?
NSAID-induced gastropathy primarily results from the inhibition of cyclooxygenase (COX) enzymes, which are responsible for producing prostaglandins (PGE2) and prostacyclin. These prostaglandins play a crucial role in maintaining gastric mucosal blood flow, promoting mucus and bicarbonate secretion, and protecting the stomach lining. By blocking COX, NSAIDs disrupt these protective mechanisms, leading to mucosal damage, erosion, and ulcers
Effects on COX 1 and COX2
Inhibition of COX-1 and COX-2: NSAIDs, especially traditional NSAIDs, inhibit both COX-1 and COX-2, which are involved in the production of prostaglandins. COX-1 is constitutively expressed in various tissues, including the stomach, while COX-2 is induced in response to inflammation.
