NSAIDs Flashcards
(25 cards)
COX-1 functions?
Physiological functions/ house-keeping/maintenance
COX-2 functions
Inflammatory mediators production
COX-1 and COX-2 mechanism?
Catalyzes this rxn: Arachidonic acid -> cyclic endoperoxides (prostacyclins, prostaglandins, TXA2)
Prostacyclin functions?
PGI2: dec platelet aggregation and dec vascular tone(vasodilation)
Prostaglandins function?
PGE1: vasodilation, fever, pain
PGE2: uterine contraction
PGF2a: uterine contraction
Thromboxane function?
TXA2: platelet aggregation and vasoconstriction
Is paracetamol an NSAID?
No
Paracetamol alt name
Acetaminophen
Acetaminophen MOA
inhibits COX mostly in CNS
Acetaminophen used instead of aspirin to avoid ___________
Reye syndrome in kids w viral infection
Acetaminophen ADRs?
Hepatic necrosis by glutathione depletion
Hepatic necrosis by acetaminophen antidote?
N-acetylcysteine
Classification of NSAIDs?
Non selective COX Inhibitors (reversible and irreversible)
Selective COX-2 inhibitors
Non selective COX inhibitors subclassification?
Irreversible: aspirin Reversible: ibuprofen Naproxen Indomethacin Ketorolac Diclofenac
Aspirin MOA?
Inhibits COX 1 n 2 by Covalent acetylation
Affect lasts until new platelets are produced
Aspirin clinical use?
Low dose- dec platelet aggregation
Intermediate dose- antipyretic and analgesic
High dose- anti inflammatory
Aspirin ADRs?
Gastric ulceration Tinnitus Allergic rxn Interstitial nephritis Mixed metabolic acidosis + resp alkalosis
Aspirin OD treatment?
NaHCO3
Reversible non selective COX inhibitors MOA?
Inhibits prostaglandin synthesis
Reversible Non selective cox inhibitors clinical use?
Antipyretic
Analgesic
Anti inflammatory
Indomethacin to close PDA in kids
NSAIDs (reversible non selective) ADRs?
Interstitial nephritis
Gastric ulcers
Renal ischemia
Aplastic anemia
Selective cox 2 inhibitor?
Celecoxib
Celecoxib MOA?
Only inhibits inflammation and pain
TXA2 and gastric mucosa spared
Celecoxib clinical uses?
RHEUMATOID ARTHRITIS
OSTEOARTHRITIS
