NSAIDs

Question 1

Effects when COX-1 is inhibited

Answer 1

Prevention of cardiovascular events

Question 2

Effects when COX-2 is inhibited

Answer 2

Anti inflammatory and anti analgesic effects

Question 3

Drug regimen to treat pain caused by malignancy

Answer 3

NSAIDs + opioids

Question 4

NSAIDs classification

Answer 4

a) Non-selective COX inhibitors
b) Selective COX-2 inhibitors (celecoxib, rofecoxib & valdecoxib)
c) Analgesic & antipyretic with poor anti inflammatory action (acetaminophen)

Question 5

Which NSAID is a salicylate

Answer 5

Aspirin (acetylsalicylic acid)

Question 6

Which NSAIDs are acetic acid derivatives

Answer 6

Indomethacin
Ketorolac
Nabumetone

Question 7

Which NSAIDs are pyrazolone derivations

Answer 7

Oxyphenbutazone
Phenylbutazone

Question 8

Which NSAIDS are propionic acid derivatives

Answer 8

Ibuprofen
Ketoprofen
Nepeoxen

Question 9

Which class does Mephenmic acid belong to

Answer 9

Fenamate (category of non-selective COX inhibitors)

Question 10

Which NSAIDs are enolic acid derivatives

Answer 10

Piroxicam
Tenoxicam

Question 11

Lowest half-life of?

Answer 11

Aspirin 0.25h

Question 12

Highest half-life of?

Answer 12

Oxaprozin 58h

Question 13

Aspirin therapeutic dose

Answer 13

Low range (<300mg/d) anti platelet eff.
Intermediate range (300-2400mg/d) antipyretic & analgesic
High range (2400-4000mg/d) anti inflammatory eff.

Question 14

Half-life of aspirin at low dose

Answer 14

3.5h

Question 15

Half-life of aspirin at high dose

Answer 15

15h

Question 16

Topical use of salicylic acid

Answer 16

• Acne, corn, calluses and warts
• In arthritis cream and sports rub as methyl salicylate

Question 17

Half-life of ibuprofen

Answer 17

2h

Question 18

Naproxen and Piroxicam used in?

Answer 18

• Mild to moderate pain (arthritis and gout)
• dysmenorrhea and headache

Question 19

Indomethacin used in?

Answer 19

Infants to close patent ductus arteriosus

Question 20

Only NSAID available in parenteral form

Answer 20

Ketorolac

Question 21

Aspirin drug interactions

Answer 21

Aspirin can displace warfarin, phenytoin or valproic acid resulting in higher free concentrations of these agents

Question 22

Aspirin chronic toxicity

Answer 22

Gastric ulceration
Upper GI bleeding
Acute renal failure
Interstitial nephritis

Question 23

Aspirin toxicity at high doses

Answer 23

Tinnitus
Vertigo
Hyperventilation
Respiratory acidosis

Question 24

Toxicity of Ketorolac

Answer 24

GI and renal damage with longer administration

Question 25

Toxicity of Indomethacin

Answer 25

Hematologic reactions

Question 26

Toxicity of rofecoxib and valdecoxib

Answer 26

Risk of MI and stroke

Question 27

Acetaminophen clinical use

Answer 27

Aspirin substitute esp. in children with viral infections and in those with any type of aspirin intolerance

Question 28

Acetaminophen half-life

Answer 28

2-3h

Question 29

Overdose effect and antidote of acetaminophen

Answer 29

Hepatotoxic Acetylcysteine

Question 30

Preferred drug in pregnancy

Answer 30

Acetaminophen

Question 31

Why should NSAIDs be avoided in the third trimester

Answer 31

Risk of premature closure of ductus arteriosus