NSAIDs, Acetaminophen, DMARDS, and drugs for gout

Question 2

What does NSAID stand for?

Answer 2

Nonsteroidal Anti-Inflammatory Drug

Question 3

Which enzyme do NSAIDs primarily inhibit?

Answer 3

Cyclooxygenase (COX)

Question 4

True or False: NSAIDs can be used to reduce fever.

Answer 4

True

Question 5

Fill in the blank: The two main types of COX enzymes are COX-1 and ______.

Answer 5

COX-2

Question 6

What is the primary therapeutic effect of NSAIDs?

Answer 6

Anti-inflammatory, analgesic, and antipyretic effects

Question 7

Which NSAID is commonly used for cardiovascular protection?

Answer 7

Aspirin

Question 8

Multiple Choice: Which of the following is NOT a common side effect of NSAIDs? A) Gastrointestinal bleeding B) Liver damage C) Kidney damage D) Weight gain

Answer 8

D) Weight gain

Question 9

What is the mechanism of action of NSAIDs?

Answer 9

Inhibition of cyclooxygenase enzymes, leading to decreased production of prostaglandins

Question 10

True or False: All NSAIDs have the same risk for gastrointestinal side effects.

Answer 10

False

Question 11

What are the common indications for NSAID use?

Answer 11

Pain relief, inflammation reduction, and fever reduction

Question 12

Fill in the blank: The pharmacokinetics of NSAIDs includes absorption, distribution, metabolism, and ______.

Answer 12

Excretion

Question 13

Which NSAID is often preferred for osteoarthritis due to its safety profile?

Answer 13

Naproxen

Question 14

Multiple Choice: Which of the following NSAIDs is considered a selective COX-2 inhibitor? A) Ibuprofen B) Celecoxib C) Aspirin D) Indomethacin

Answer 14

B) Celecoxib

Question 15

What is the primary route of excretion for NSAIDs?

Answer 15

Renal excretion

Question 16

True or False: NSAIDs can exacerbate hypertension.

Answer 16

True

Question 17

What is the role of prostaglandins in inflammation?

Answer 17

Prostaglandins promote inflammation, pain, and fever.

Question 18

Fill in the blank: The half-life of many NSAIDs is typically between ______ hours.

Answer 18

1 to 6 hours

Question 19

Which population is at higher risk for NSAID-related renal complications?

Answer 19

Elderly patients

Question 20

What is an important consideration when prescribing NSAIDs to patients with asthma?

Answer 20

NSAIDs may exacerbate asthma symptoms in some patients.

Question 21

Multiple Choice: Which of the following NSAIDs has the highest risk of gastrointestinal side effects? A) Aspirin B) Ibuprofen C) Naproxen D) Indomethacin

Answer 21

D) Indomethacin

Question 22

True or False: Acetaminophen is classified as an NSAID.

Answer 22

False

Question 23

What is the significance of the COX-2 enzyme in pain management?

Answer 23

COX-2 is primarily involved in inflammation and pain, making it a target for analgesic therapy.

Question 24

Fill in the blank: The risk of cardiovascular events can increase with the long-term use of ______.

Answer 24

Certain NSAIDs

Question 25

What is the primary action of NSAIDs on the gastrointestinal tract?

Answer 25

Inhibition of prostaglandin synthesis, leading to decreased mucosal protection.

Question 26

Which NSAID is often associated with Reye's syndrome in children?

Answer 26

Aspirin

Question 27

Multiple Choice: Which of the following NSAIDs is a prodrug? A) Diclofenac B) Sulindac C) Ketorolac D) Meloxicam

Answer 27

B) Sulindac