NSAIDS, Tylenol

Question 1

COX-1 & COX-2 (drugs)

Answer 1

Aspirin (small dose good for cardio)
Ibuprofen (Motrin, Advil)
Naproxen

GI upset/bleed
Abdominal pain

Question 2

COX-2 (drugs)

Answer 2

Celebrex/Celecoxib

Reduces pain, fever, inflammation

GI protected!!
No anti-platelet effect

Question 3

Acetaminophen

Answer 3

Tylenol

Question 4

Acetaminophen

Answer 4

analgesic
anti-pyretic

NOT anti-inflammatory

Question 5

NSAIDS

Answer 5

anti-inflammatory
anti-pyretic
analgesic
anticoagulant
anticancer

Question 6

Acetaminophen: MOA

Answer 6

Blocks COX enzyme in brain/spinal cord

*pain & fever!

Question 7

NSAIDS (selective): MOA

Aspirin

Answer 7

inhibits COX, ALL PGs

reduces pain, stiffness, swelling
fever reduction due to vasodilation of superficial blood vessels
inhibits platelet aggregation
Prevents MI and reduces coronary artery thrombosis

Question 8

NSAIDS (non-selective): MOA

Answer 8

-

Question 9

PGs

Answer 9

responsible for inflammation, pain, fever, coagulation
hormones created during chemical run at site of injury
not secreted, but are created at the time problem exists

*amount of dosage will dictate which PGs it will inhibit

Question 10

COX-1

Answer 10

• help regulates normal cell activity and maintain homeostasis
• synthesizes PGs to protect cells, maintain function

Question 11

COX-2

Answer 11

• induced when cell is injured
• synthesizes PGs that mediate pain, inflammation
• used in patients with RA, OA

Question 12

Which drug is the oldest non-narcotic and is derived from willow bar?

Answer 12

Aspirin

Question 13

Which drug is associated with Eye syndrome in meds?

Answer 13

Aspirin

Question 14

Which drug is NOT effective for chronic pain?

Answer 14

Aspirin

Question 15

What is interactive with aspirin?

Answer 15

higher dosage of NSAID blocks the cardioprotective effect

Question 16

What do baby aspirin help prevent?

Answer 16

clots, DVT, MI

Question 17

What are side effects of aspirin?

Answer 17

GI distress/bleeding/ulcer
Renal dysfunction
Rene syndrome in peds

Question 18

What is Reye Syndrome?

Answer 18

Sudden (acute) brain damage and liver function problems of unknown cause. Up to 14 years if given for viral infection.

Question 19

At high dosage of aspirin what are some effects?

Answer 19

tinnitus
vertigo
hyperventilation
respiratory alkalosis
metabolic acidosis
dehydration
hyperthermia
coma & death

Question 20

How long is aspirin permanently binded on RBC?

Answer 20

7-12 days

Question 21

Where is aspirin absorbed?

Answer 21

stomach and intestine

Question 22

Can it cross into placenta and breast milk?

Answer 22

Yes

Question 23

What is the half life of aspirin?

Answer 23

2 hours

Administer every 4 hours

Question 24

What are contraindications of aspirin?

Answer 24

peptic ulcers
DM
gastritis
hemophilia
warfarin
alcohol
hyperkalemia
increase risk of cerebral hemorrhage

Question 25

What are interactions with aspirin?

Answer 25

``` DM meds Warfarin Methotrexate Spironolactone Penicillin Inhibit absorption of Vit C ```

Question 26

You can get instant relief with one dose of what drug?

Answer 26

Ibuprofen

Question 27

How many days does it take for ibuprofen to have an anti-inflammatory effect?

Answer 27

3 days to weeks

Question 28

What has a lower risk of GI bleeds?

Answer 28

Ibuprofen (Motrin, Advil)

Question 29

What are advise effects of NSAIDS?

Answer 29

>65 co-morbidities | heart failure, GI ulceration, renal impairment

Question 30

What are contraindications of ibuprofen?

Answer 30

hypersensitivity with other NSAIDS Active GI bleed peptic ulcer 4rd trimester

Question 31

What COX-2 drug can be taken with anticoagulants?

Answer 31

Celebrex

Question 32

What is the primary concern for celebrex/?

Answer 32

Increase risk of MI & Stroke! | COX-2 inhibition may cause selective loss of PGs that cause vasodilation an prevent thrombosis

Question 33

What are pathologies that celebrex is used for?

Answer 33

OA RA Enclosing spondylitis Dysmenorrhea

Question 34

What are common side effects of celebrex?

Answer 34

GI back pain headache High blood pressure

Question 35

What are uncommon side effects of celebrex?

Answer 35

``` heart failure confusion asthma kidney impairment blurred vision tinnitus GI ulceration ```

Question 36

Which drug is the choice for children?

Answer 36

Acetaminophen

Question 37

What are the side effects of acetaminophen?

Answer 37

inhibits RBC/WBC/neutrophils to produce by bone marrow and becomes immunocompromised with certain dosage

Question 38

Which drug has a unique anti-platelet effects at low dose?

Answer 38

Aspirin

Question 39

Which drug is used for chronic pain?

Answer 39

Celebrex

Question 40

Which drug is high risk for GI bleed?

Answer 40

Aspirin

Question 41

Which drug acts quickly for pain an dress risk for GI?

Answer 41

Ibuprofen