Flashcards in nuclear Deck (153)
Cardiac uptake on a scan - not PET
MIBG, sestamibi, thallium
MIBG vs. Octreotide
MIBG and octreotide can both localize to neuroendocrine tumors (pheochromocytoma, paraganglioma, **neuroblastoma, and carcinoid). In almost all cases, MIBG is the way to go. The exceptions are **carcinoids and extraadrenal pheochromocytomas, gastrinoma (according to Gainesville)
what nuclear scan to look for PCP pneumonia
What is thyrogen and when is it used in nuc med?
a highly purified recombinant form of human thyroid stimulating hormone (TSH), given by injection prior to I-131 study as an alternative to going off thyroid hormone
normal distribution of octreoscan?
Liver, spleen, kidneys, thyroid, GB, bladder, Normal pituitary gland
What is MIBG structurally similar to?
Norepinephrine - thus scanning for Pheos, **neuroblastoma, and paragangliomas
half life of Tc-99m
In-111 half life
2.8 (3) days
In-111 WBC scan normal distribution
liver, spleen, bone marrow (NO urinary or GI tract activity!)
I-123 half life
Iodine scan normal distribution
thyroid gland (target organ)
stomach (target organ)
bladder (target organ)
I-131 half life
What's the prep before I-131 scanning?
D/c thyroid hormone or us thyrogen
octreoscan - what radiopharmaceutical?
Octreoscan - what's it used for?
Neuroendocrine tumors: carcinoid tumour, paraganglioma(s), glomus jugulare/tympanicum/vagale,
carotid body tumour, pheochromocytoma, small cell lung cancer, pituitary adenoma, neuroblastoma, medullary thyroid carcinoma, islet cell tumour of pancreas
octreotide is an analogue of what?
somatostatin (thus useful for neuroendocrine tumors)
MIBG - what radiopharmaceutical?
MIBG - used for what?
medullary thyroid carcinoma
MIBG normal distribution
gastrointestinal tract (faint)
FDG - half life
Gallium-67 - half life
78 hours (think 67, 78)
Ga-67 normal distribution
liver (site of highest uptake)
kidneys and bladder in the first 24 hours (only!)- faint uptake can still be normal for up to 72 hours
breast uptake (especially in pregnant and lactating women)
mild diffuse lung uptake at 24 hours or less
What's a superscan in a bone scan? What are causes?
intense symmetric activity in the bones with diminished renal and soft tissue activity
diffuse metastatic disease (prostatic, breast cancer, TCC, lymphoma
metabolic bone diseases (renal osteodystrophy, hyperparathyroidism -often secondary hyperparathyroidism-, osteomalacia (will involve distal skeleton smoother uptake)
myelofibrosis / myelosclerosis
widespread Paget's disease
sestamibi - normal distribution
thyroid, parathyroid, heart
sestamibi - used for?
parathyroid adenoma detection
cardiac imaging (MIBI)
sulpher colloid - what radiopharmaceutical?
sulpher colloid normal distribution
spleen, Kupffer cells in the liver and a small proportion by bone marrow
Tc-99m pertechnetate - used for?
Meckel's scan (also thyroid in pediatrics, parathyroid, testicle)