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Flashcards in Nucleotide biosynthesis Deck (11)
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1

Drugs that affect formytetrahydrofolate (hint: Too Much Stuff)

Sulfanomides (PABA analogs)

Methotrexate (folate analog - mammalian)

Trimethropin (folate analog - bacterial)

2

Mechanism of sulfanomides

3

Mechanism of methotrexate

4

Mechanism of trimethoprim

5

Role of mycophenolic acid in IMP conversion to GMP and AMP

Inhibits IMP dehydrogenase

Used to prevent graft/transplant rejection due to proliferating B + T cells

6

Role of allopurinol in gout

7

Lesch-Nyhan disease

8

Outline the process of generating CTP and dTMP from UMP

9

Differences between pyrimidine and purine biosynthesis

10

Role of 5 fluorouracil in dTMP formation

11

Role of methotrexate on dTMP formation