nutritional support Flashcards

(36 cards)

1
Q

reasons for malnutrition (7)

A

N/V/D: drug induced or chemo
Changes in appetite: chemotherapy, Mg deficiency
Early satiety: ascites (full after small meal, due to fluid in abdomen)
Malabsorption: IBD (↓ area for absorption due to surgical resection)
Nutrient loss: dialysis
Impaired metabolism: stress, trauma, pregnancy, wound healing
Reduced volitional intake: delirium, poor dentition

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2
Q

complications from malnutrition (6)

A

Poor wound healing
Compromised immune status
Impairment of organ function
↑ use of healthcare resources
↑ mortality
↑ complications

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3
Q

Nutritional screenings

A

to identify individuals at risk (higher score = bad)
○ Unintentional weight loss in past 6 months
○ Nutritional intake in past 1 week
○ Muscle wastage (from temple / clavicle bone)

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4
Q

Nutritional assessments (2)

A

● Nutritional assessment:
○ Anthropometric: height, weight, BMI
○ Biochemical: electrolyte, albumin (lower in malnutrition)
○ Clinical: history (surgery), muscle stores (hand grip strength)
○ Dietary: how long malnutrition was, normal intake

● Seven-Point Subjective Global Assessment (1 = bad, 7 = good)
○ Weight loss in the past 6 months
○ Dietary intake in past 2 weeks
○ Gl symptoms (persisted > 2 weeks)
○ Functional status
○ Disease state affecting nutritional requirements
○ Muscle wastage / Fat stores / Edema (↓ dry weight)

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5
Q

energy requirements

A

25-35 kcal/kg body weight

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6
Q

How to measure total energy expenditure (TEE)

A

Total energy expenditure (TEE) = Resting Energy Expenditure (REE) / Basal Metabolic Rate (BMR) + Physical Activity

TEE = REE (BMR) x activity factor ( x disease-specific stress factor)

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7
Q

Modes of measurement of REE (2)

A

○ Indirect calorimetry (Gold): measurement of gas exchange
○ Predictive equations (only estimations)

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8
Q

Protein requirements

A

0.8 g/kg/day (healthy)

Trauma / surgery / burn / sepsis = 1.5-2 g/kg/day (up to 2.5)

CKD not on dialysis = 0.6-0.8

on HD/PD = 1.2 g/kg/day

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9
Q

Definition of enteral nutrition

A

Nutrition provided through the GIT via a tube, catheter, or stoma that deliver nutrients distal to the oral cavity
● For patients who are unable to receive adequate nutrition by oral route: swallowing impairment, mechanical ventilation, altered mental status, motility disorders

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10
Q

Different types of enteral access devices (4)

A

NG, PEG, NJ, PEJ

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10
Q

what is NG and what are the pros and cons

A

Feed into stomach, use more GIT
More physiologic (preferred)
↑ tolerance to bolus feeding (normal eating schedule)
↑ tolerance to enteral product (osmolarity, pH)
Used for venting (aspirate content through tube)

Cons: DON’T USE in patients with delayed gastric emptying
Vomit ↑ aspiration risk = NG tube draw out acid = ↓ vomit

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10
Q

what is NJ and what are the pros and cons

A

Feed into Jejunum, duodenum
● Smaller bore (narrow outlet btwn stomach & duodenum), less discomfort
● Can use in dysfunctionality in proximal GIT (delayed emptying or obstruction)
● Minimize aspiration risk

Cons: Higher risk of tube clogging

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11
Q

what is the preferred enteral route

A

NG, PEG

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12
Q

what are the 2 modes of entry for EN

A

nasal: not for long term, less comfortable, change every month

stomy: need surgery, long term, change every year

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13
Q

2 modes of intake for EN

A

Bolus: mimics oral intake (by gravity) & more physiologic, no pump, more freedom

Continuous: better tolerated, less aspiration risks, need pumps

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14
Q

types of EN nutrition (3) and egs

A

Modular: singular nutrient –> fortifier (eg. myotein: high whey after surgery, MCT oil: bypass lymphatic system, used in CHYLE [leakage in lymphatic drainage system]

Semi-elemental: partially hydrolysed nutrition –> for impaired GI function (eg. peptamen - metallic taste)

Polymeric: intact macro-nutrients –> req sufficiently functional GIT (eg. boost isocal - most isotonic, less osmotic diarrhea, ensure - clear fluids are more easily digested)

15
Q

what is immune modulating/disease specific EN

A

specific addition / restriction of specific nutrients to meet needs for certain diseases (nepro?)

16
Q

management of EN tolerance (5)

A

● Continuous instead of bolus
● Use of prokinetic (metoclopramide, domperidone, IV erythromycin)
● Post-pyloric feeding if intolerant to gastric feeding
● Use of isotonic formula (boost isocal)
● Semi-elemental / elemental feeds for malabsorption issues

16
Q

drug-nutrient interactions for EN (4)

A

Inappropriate drug administration can cause:
○ Binding of medication to tube (e.g. phenytoin)
○ Medication-feed interaction (e.g. FQ → sep from Ca)
○ Alteration of dosage (e.g. Sustained-release, enteric coating)

Stop feedings, flush access device before and after drug with water (usually not an issue with bolus/intermittent feeding)

16
Q

complications of EN (6)

A

ROTAIN
1. Refeeding syndrome
2. Occlusion of feeding tube
a. Jejunal > gastric tube (due to small bore)
b. Medication administration
c. Formula : concentrated / high protein / fibre-enriched
3. Tube displacement (due to vigorous coughing)
4. Aspiration
5. Infections (2nd to microbial contamination) → NO water to dilute
6. Nausea / vomiting / diarrhoea / constipation

17
Q

monitoring of EN (6)

A

● Signs of intolerance (N/V/D)
● Gastric residual volume = amount aspirated from the stomach into feeding tube (high GRV = inability to empty stomach content downstream = GI dysfunction)
○ pH (1-2), consistency, colour
● Blood glucose level
● Electrolytes
● Fluid balance
● Weight (long-term)

18
Q

5 benefits to using EN

A

○ Maintain functional integrity
○ 1st pass metabolism, promote efficient nutrient utilization,
○ Maintain normal gallbladder function,
○ Maintain gut-associated & mucosal-associated lymphoid tissue
○ Less complications than parenteral nutrition & less expensive

19
Q

definition of parenteral nutrition + egs (4)

A

Patients who are unable to receive or tolerate adequate nutrition by the enteral route

○ Paralytic ileus
○ Small bowel obstruction
○ High output / proximal fistula
○ Mesenteric ischaemia

20
Q

types of parenteral access devices

A

peripheral and central

21
what is peripheral catheter and cons (2)
Tip position is outside of central vessels Cons: ● Requires frequent re-site (q72h) or if inflamed sites ● Nutrient delivery is limited by osmolarity & conc --> not long term
21
what is central catheter and pro + con
Catheter tip in large bore blood vessels (distal superior vena cava, inferior vena cava, right atrium) Pro: Longer term care Con: More infection risk (depending on type)
22
Types of central catheters and definitions
Non-tunnelled central venous catheter: Goes into large bore blood vessel, straight out of chest. short lines --> shorter duration for bacteria to enter blood, shorter placement durations (~2w) Tunnelled central venous catheter: Tunnels under skin --> infection risk Peripherally inserted central catheter: Inserted peripherally (arm) and connects to heart Implanted ports: Common in oncology patients, more for intermittent meds
23
composition of PN (macronutrients)
amino acids: 4kcal/g [mixture of essential + non-essential AA] dextrose (glucose): 3.6kcal/g [req to avoid excessive ketone pdtn, high infusion rate exceeding max glucose oxidation --> hyperglycemia, hepatic steatosis] lipids emulsion: 10kcal/g [linoleic acid + a-linoleic acid]
24
composition of PN (micronutrients)
electrolytes: Ca, K, Na, Mg, Phos, acetate + chloride (acid-base balance) multivitamins: fat soluble - A, D, E, K ; water soluble - B, C trace elements: zinc, selenium, iron, iodine ; copper, manganese --> excreted in bile, CI in liver/gallbladder impairment
25
drug-nutrient interactions of PN (3)
Usually not a problem if administering via separate lumens of same access device ● Y-site compatibility ● Total parenteral nutrition (TPN) = without lipids / Total nutrition admixture = with lipids ● Administration of incompatible drugs may cause: ○ PPT, loss of drug activity, toxicity ○ Phase separation of lipid emulsions (oil & water)
25
how to prevent drug-nutrient interactions of PN (2)
● Administer via separate peripheral IV cannula ● Pause PN administration, flush access device before & after drug
26
complications of PN (8)
● Occlusion in IV catheter --> push, pause technique to clear: ○ Thrombosis / clotting, inappropriate flushing, precipitation from incompatibilities, crystallization, lipid residue ● Mal-positioning (tugging of line) ● Catheter-related bloodstream infection (CRBSI) Metabolic complications ● Refeeding syndrome ● Hyper/hypoglycemia ● Fluid overload ● Intestinal failure associated liver disease ( even if pt is on long term TPN, give trophic feed to keep gut stimulated) ● Metabolic bone disease (aluminium → osteoporosis or lack of vitamin D supp)
27
monitoring of PN (8)
● Blood glucose level ● Electrolytes ● Fluid balance ● Weight ● LFT (IFALD) ● Renal functions (SCr, blood urea nitrogen, Cl/ CO2) ● Triglycerides ● Signs of infection (CBC, fever, redness / pus around site)
27
physiology of refeeding syndrome
Starvation / Malnutrition triggers catabolism (↓ insulin / ↑ glucagon) → break down glycogen, fats & muscles In order to maintain circulating electrolyte levels: Na, Cl, are stored extracellularly and K, Mg, P are stored intracellularly Feeding occurs (body switches back to anabolism) → ↑ insulin & drive energy production & ↑ uptake of K+, Mg 2+, PO4 into cells + fluid retention (due to change in osmotic pressure) Hypophosphatemia (huge deficit in phosphate level since it is used in production of energy in ATP (3P)) --> Potentially fatal: arrhythmia, cardiac failure, neuromuscular complications (from hypo K, Mg, P) + edema , thiamine deficiency
28
management of refeeding syndrome (5)
ICCAI Identify high risk patients Check serum electrolyte at baseline Correct deficiencies prior to feeding, defer feeding if critically low Administer thiamine (Vit B1) supplement --> cofactor in energy metabolism: 100-200mg/day x 7d Initiate feeding slowly & ↑ over next few days (start low go slow)
28
how to identify pts at high risk of refeeding syndrome
One of following: BMI<16kg/m2 Unintentional weight loss >15% in past 3-6m Little/no nutritional intake >10d Low levels of K, Mg, Phos before initiation Two of following: BMI<18.5kg/m2 Unintentional weight loss >10% in past 3-6m Little/no nutritional intake >5d Hx of alcohol misuse/drugs --> insulin, chemo, antacid, diuretics