Flashcards in NV constipation diarrhea Deck (47):
Serotonin Antagonists (N/V)
Neurokinin-1 antagonists (N/V)
Absorbents & Bulk Agents (diarrhea)
Diphenoxylate + atropine
Antiperistaltic Agents (diarrhea)
Antisecretory Agents (diarrhea)
Bulk Producers (constipation)
Polyethyline glycol 3350
Stimulant laxatives (constipation)
Saline Agents (constipation)
Intestinal Secretagogues (constipation)
Peripherally Acting Mu-opioid antagonists (constipation)
This area of the vomiting center has 3 types of receptors: 5HT3, neurokinin-1, dopamine D2
Chemoreceptor Trigger zone (CTZ)
Is the CTZ inside or outside the BBB?
What is the cerebral cortex affected by?
Which area of the vomiting center are best targeted to treat motion system?
Vestibular system (anticholinergics and antihistamines)
Best treatment for mild n/v in pregnancy?
Pyridoxine (B6) or Doxylamine
best treatment for severe n/v in pregnancy?
treatment for hyperemesis gravidarum
DO NOT GIVE FOR nausea/vomiting in pregnancy...and why
Ondansetron - cleft palate/heart defects
In which class of drugs will you have a risk of EPS?
phenothiazines, butyrophenones, benzamides
Droperidol and haloperidol act on which receptors, treating N/V
which of the serotonin antagonists if most effective at preventing delayed nausea related to chemo (longest 1/2 life)
Aprepitant (Neurokinin-1) has MANY interactions due to being what substrate?
which anti n/v med to take the night before surgery?
which n/v med to take before anesthesia?
palonsetron or dexamethasone
n/v meds recommended after surgery?
Droperidol or serotonin antagonists
most of the anti-constipation meds take 1-3 days. For faster relief, which hyperosmotic do you choose?
Polyethyline glycol (PEG) 3350
what to be cautious of when prescribing mineral oil for constipation
aspiration risk! avoid in elderly
contraindication of castor oil (stimulant laxative)?
PREGNANCY - causes uterine contractions and rupture
Which n/v med is used as PROPHYLAXIS for constipation, and takes up to 72 hours for effect?
The saline agents need to be avoided in which type of patient?
RENAL failure, CHF, elderly
When to prescribe Mu-opioid receptor antagonists
RESERVE for special situations - give to patients taking opioids to prevent the decrease in GI motility that they cause
do you want to use antiperistaltic agents for infectious diarrhea?
NO! don't want to keep the organism inside longer.
MOA absorbents/bulk agents
absorb water into intestines, forming gel