OB Path 3: Uterine Sq Cell Cancer and Breast Cancer Flashcards Preview

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Flashcards in OB Path 3: Uterine Sq Cell Cancer and Breast Cancer Deck (12):
1

signs of maturation in uterine epithlium

flattening and clear cytoplasm (due to glycogen storage)

2

epidemiology of TNBC

blacks, younger, obese

3

pathogenesis of TNBC

86% have p53 mut
20% have BRCA (***70% of BRCA pts will have TNBC**)
others are germline and somatic mutations

4

Where does TNBC commonly met to?

brain, lung, and liver, and distant LN

NOT USUALLY BONE

5

irregular lumens (often slit line and peripheral)

usual ductal hyperplasia

6

regular lumens

atypical ductal hyperplasia

7

basal like morphology

TNBC

8

small uniform, evenly spaced cells with well defined boarders in a cribiform pattern

atypical ductal hyperplasia

9

when it presents it is usually at a higher stage and grade

TNBC

10

CK 5/6 +

TNBC

11

bridges (often stretched and twisted)

usual ductal hyperplasia

12

ridged bridges

atypical ductal hyperplasia