Obesity Flashcards
(15 cards)
Talk about obesity
- it occurs when theres increased energy storage
- resutling from an imbalance between energy intake and energy expenditure
- defines as body mass index more than 25 abd more than 30 kg/m
Potential mechanisms of herbal medicine for obesity?
- Decrease food intake, suppression of appetite (central)
- Decrease inflammation of liver
- Decrease lipogenesis
- Inhibition of lipid absorption
- Increase insulin secretion
- Increase thermogenisis
Anti obesity mechanisms?
- Metabolic and thermogenic stimulants
- Appetite regulation effect
- Lipase inhibition effect (strep. Toxytricini derivative)
- Amylase inhibition effect
Inhibition of adipogenesus & induction of adipocytes apoptosis
Talk about glucomannan as an anti obesity component مهمهمهمهم
- it’s a polysaccharide
- it’s a natural fiber forbed by B 1,4 linked D mannose & D glucose monomets
الجسم مابيقدر يكسرها بتحسسك انك full
MOA: it has a capacity to absorb 50 times its weight of water volume, thus producing DELAYED gastric emptying with a stiety feeling
Side effects and precautions and intercations of glucomannan مهمهمهم
S/e: GIT complaints, diarrhea, loose stool, flatulence. Not for someone with GIT blockade
Precautions: pre-existing esophageal problems should avoid all of them
Interactions: antibiotics يمنع امتصاصهم
Talk about garcinia fruit
- The extract of its exocarp has shown ANOREXIGENIC effects
- contains high amounts of HYDROXYCITRIC ACID. What’s MOA of it?
1. Reduce food intake (cns suppression of appetite)
2. Reduce body fat by —> regulating serotonin levels to stiety (ssri intercation)
3. Increase fat OXIDATION
4. Decrease de novo lipogenesis
5. It blocks synthesis of ATP citrate lyase
Garcinia is safe up to…?
2800 mg a day
T/F Garcinia has very mild s/e with the most common include GI complaints like nausea and diarrhea
True
Herb drug interactions of garcinia?
- Green tea: it might enhance the hepatotoxic effect of the tea
- SSRI: serotonin syndrome
Active ingredient of green coffee
Chlorogenic acid
Chlorogenic acid/green coffee mechanism of action in reducing weight?
- Reducing pancreatic lioase actibity
- Inhibition HMG-CoA reductase & Aacetyl-CoA cholesterol acyltransferase & fatty acid synthase
- Increasing B- oxidation
- Increasing expression of PPAR a in liver (a nutrient sensor that regulates genes important in 2 things: B oxidation & fatty acid transport8
Green tea causes thermogenesis & suppression of appetite. Why?
Probably because of caffeine
What are the antioxidants in green tea what do they do
- Catechins
2.epigallocatechin 3 gallate
They inhibit NE breakdown which causes an increase in calories burned
MOA of white kidney bean in obesity?
It contains PHASEOLAMIN which is an alpha amylase inhibitor.
It inhibits pancreatic amylase activity
Which lowers —> glycemia & calorie absorption
How? By delaying/preventing COMPLEX CARBOHYDARE DIGESTION
T/F chitosan cannot be absorbed by the GIT but it can…
It can absorb the fat that can prevent the digestive system from absorbing TG and cholesterol
