Obesity Flashcards
(42 cards)
Obesity occurs..
when excess calories are stored as fat
Obesity
- most prevalent preventable health problem in US
- increase risk of morbidity and mortality
- Nearly 70% of Americans are overweight or obese
Pathophysiology of Obesity
- all body function requires energy
- excess energy (kcals)/nutrients are stored as triglycerides in fat cells
- Nutrients provide energy
- 70% of energy expended goes to maintain BMR
- Physical activity accounts for 5-10% of energy expended
Etiology of Obesity
- excess energy and/or decreased energy expenditure
- appetite
- GI filling
- Hormonal factors
- emotions
Hormonal factors and Obesity
- Leptin
- Insulin
- Thyroid Hormone
Risk Factors
- heredity (25-40% of obesity)
- physical inactivity
- cultural factors
- environmental factors
- socioeconomic factors
- psychological factors
- addiction
- coping mechanism
Adipose Tissue
- mature adipose cells do not multiply
- however, immature adipose cells multiply in presence of estrogen during puberty and late adolescents, during breastfeeding, overweight middle aged adults
Clinical Manifestations: Upper body obesity
- waist hip ratio >1 in men, >0.8 in women
- increased levels of circulating free fatty acids
- increased risk of HTN, dyslipidemia, heart disease, stroke, hyperinsulinemia
APPLE
Complications of Obesity
-HTN
-Coronary heart disease
-Heart failure
-Stroke
-Metabolic syndrome
-Insulin Resistance
-DM2
-Sleep apnea
-Reproductive impairment
-Gallstones
-Cancer
Joint Pain/OA
Reproductive Impairment
Men: decreased androgen
Women: menstrual irregularity, polycystic ovary syndrome
Cancer
- colon
- breast
- endometrial
Obesity Management
- Diet
- Exercise
- Behavior modification
- Pharmacotherapy
- Surgery
Apple vs. Pear
Pear is healthier, lower body weight
Apple: upper body weight
Diagnostic Tests: Anthropometry
- BMI (kg divided by meters)
- Skin folds
- Hydrodensitrometry (water displacement)
- Bioelectrical impulse (low energy electrical impulse)
- Waist circumference (> or = 40 in men, 35 in women)
Diagnostic Tests: Labs
- Thyroid panel
- Serum glucose
- Lipid profile
- Electrocardiography
Pharmacologic Interventions
- Amphetamine and non-amphetamine appetite suppressants
- Appetite suppressant
- Fat absorption inhibitor
- OTC
Amphetamine and non-amphetamine appetite suppressants
- Phentermine
- Stimulate CNS
Appetite suppressant
- Meridia (Sibutramine)
- Appetite suppressant: lowers cholesterol and triglycerides, increase metabolic rate
- removed from the market in 2010 due to increased risk of heart attacks and strokes
Fat absorption inhibitor
Orlistat (Xenical)
Qysmia
- phentermine (stimulant) and topiramate (anti-seizure)
- avoid in pregnancy
Belviq
- locaserin HCl
- seratonin 2C receptor agonist/stimulator
Methycellulose
bulk-forming product
-creates sensation of fullness
Nutrition
- regular, small servings
- create 500-1,000 calories deficit
- “yo-yo” dieting may result in metabolic deficiencies that make subsequent weight loss more difficult
women calorie recommendation
1,000-1,200 kcal