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Flashcards in obestiy Deck (30)
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0

underweight

<18.5

1

normal weight

18.5-24.9

2

overneight

25-29.9

3

overweight

25-29.9

4

obesity 1

30-34.9

5

obesity 2

35-39.9

6

obesity III (extreme)

>40
6.3% population

7

excess calories stored as

triglycerides in two ways--adipose cellular hyperplasia & adipose cellualr hypertrophy

8

adipose cellylar hyperplasia

increase in number of cells
early onset
extreme

9

adipose cellualr hypertrophy

increase in size only
adult onset
mild

10

weight loss leads to

change in adipose cell size but not number (this remains constant even with weight loss)--this is reason why weight loss is so hard and so often relapse

11

peptides and NT that increase appetite

NPY
AGRP
MCH
Ghrelin*
endocannabinoids
Orexins*
Galanin
Opiods

12

peptides and nt that decrease appetite

leptin*
a-MSH
CRF
CART
Neuromedian
Urocortin
CCK*
IL6
CNTF
PYY
oxyntomodulin

13

leptin is produced in

fat cells, gut, placenta

14

leptin

signals brain how much fat is stored

15

db/db and ob/ob mice

ob- deficient
db- defect

hyperphagia
insulin R
infertility
hyperinsulinemia

16

melanin protein (MSH)

inhibits food intake

17

agouti gene/protein

inhibits mSH binding to receptor-->decrease MSH-->stimulates food intake

also competes w/ MSH for Melacortin 4R

18

carboxypeptide E

cleaves proinsulin
*fat mice lack this

19

tub gene

retinitis, other neuro deficits-->hypothal damage-->stimulates appetite

20

M4R deletion

hyperphagia, obesity

21

M3R deletion

store more fat, lower lean body mass

22

5HT 2C deletion

increase food intake, obesity, seizures

23

5HT1B deletion

blocks anorexic effects dexfenfluramine

24

Neurpeptide YKO

normal amounts of fat--losing gene does nto cause weight loss

25

candidates for treamtnet depend on

degree of risk
no baritric surgery for anyone under BMI of 30

26

malabsorptive surgery

bypass duodenum to decrease absorption
jejunoileal bypass, biliopancreatic diversion

27

restrictive surgery

small pouch restricts volume of food intake--early satiety with normal absorption
vertical banded gastroplasty, laparoscopic adjustable gastric banding

28

bombined restrive/malabsorptive

roux-en-y gastric bypass

29

complications of restrictive/malabsorptive

cholithiasis
vit B12 deficiency
incisional hernia
dumping syndrome
Fe deficient

**treat prophylactically