Obs/Gynae Flashcards

(268 cards)

1
Q

pre eclampsia definition

A

new HTN in pregnancy after 20 weeks gestation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

pathology pre eclampsia

A

endothelial cell damage and vasospasm, which can affect the foetus and almost all matenal organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

mild Pre Ec
moderate PreEc
severe Pre Ec

A
  • Mild = proteinuria and mild/moderate HTN
  • Moderate = proteinuria and 160/110
  • Severe = proteinuria and any HTN before 34 weeks or with maternal compliocations
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Early and late Pre Ec

A
  • Early = <34 weeks
  • Late = >34 weeks
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

features Pre Ec

A
  • Headache
  • Epi pain
  • Visual disturbances
  • Oedema
  • None until later stages
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Maternal compliations Pre Ec

A
  • Eclampsia
  • CVAs
  • liver/renal failure
  • HELLP
  • Pulmonary oedema
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Foetal complications Pre Ec

A
  • FGR
  • Abruption
  • Foetal morbidity and mortality
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

to confirm PreEc

A
  • urine protein measurements
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pre ec prevention

A
  • Aspirin if <16 weeks and increased risk
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Threatened miscarriage

A

Bleeding but foetus still alive, Os closed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Inevitable miscarriage

A

heavy bleeding, cervical os open

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Incomplete miscarriage

A

some foetal parts passed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Complete miscarriage

A

all foetal tissue passed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Septic miscarriage

A

contents of uterus infected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Missed miscarriage

A

Foetus has not developed or has died but not recognised until bleeding occurs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Endometriosis definition

A

Presence and growth of tissue similar to endometrium outisde the uterus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

RF endometriosis

A
  • Nulliparous
  • White
  • FHx
  • Reproductive age group
  • Retrograde menstruation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

S+S endometriosis

A
  • Cyclical pelvic pain
  • Dysmennorhoea
  • Deep dyspareunia
  • Subfertility
  • Dyschezia
  • Tenderness/thickeneing behind uterus or adnexa
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Ix endometriosis

A
  • Laparoscopy
  • Transvaginal USS
  • MRI if deeply infiltrating
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Mx endometriosis

A
  • Pain relief
  • The pill
  • GnRH agonists
  • Mirena coil
  • Laparoscopic surgery
  • Hysterectomy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Aetiology endometrial cancer

A
  • Obesity
  • T2DM
  • Nulliparity
  • Late menopause
  • Oestrogen only HRT
  • Unopposed oestrogen
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

S+S endometrial cancer

A
  • Post menopausal bleeding
  • Abnormal bleeding
  • Abnormal discharge
  • Haematuria
  • Anaemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Ix endometrial cancer

A
  • Transvaginal USS
  • Endometrial biopsy
  • Hysteroscopy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Mx endometrial cancer

A
  • Surgery = hysterectomy +/- pelvic LN
  • Radiotherapy = adjuvant
  • Progesterone therapy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Cervical cancer aetiology
- High risk HPV 16 18
26
Cervical cancer treatment for stage 2 +
- Radiotherapy - Chemo - Palliative
27
Vulval cancer sx
- itching and soreness - Persistent lump - Bleeding - Pain on passing urine
28
Ovarian cancer presentation
- No Sx - Bloating/IBS - Abdo pain/discomfort - Change in bowel habit - Urinary frequency - Bowel obstruction
29
Obstetric cholestasis
- Characterised by otherwise unexplained pruritus and abnormal LFTs +/- raised bile acids
30
Obstetric cholestasis causes/RF
- later pregancy (28 weeks) - Increased oest and prog levels - genetics - South Asian - Hep C - Multiple preg - OC previously - Gallstones
31
Obsetric cholestasis presentation
- Pruritus (palms and soles) - Fatigue - Dark urine - Pale greasy stools - Jaundice
32
Complications Obstetric Cholestasis
- Sudden stillbirth - Meconium passage - PPH
33
Obstetric Cholestasis Ix
- LFTs - Bile acids - Rise in ALP with no other abnormal LFTs = placental production
34
- Mx Obstetric Cholestasis
- Ursodeoxycholic acid (UCDA) - Emollients - Antihistamines - Vitamin K 10mg/day from 36 weeks - LFTs weekly and 10 days after delivery
35
Gestational diabetes definition
- Carbohydrate intolerance diagnosed in pregnancy which may or may not resolve after pregnancy
36
Complications GDM
- Large for date foetus - Macrosomia - Shoulder dystocia - Congenital abnormalities - Polyhydramnios - Neonatal hypoglycaemia
37
RF GDM
- Previous GDM - Previous macrosomic baby - BMI >30 - Ethnic origin - FHX diabetes (1st degree)
38
When to screen for GDM
- OGTT 24-28 weeks gestation - In morning after fasting = drink 75g glucose - Normal results are <5.6mmol/l fasting and <7.8mmol/l at 2 hours
39
GDM Mx
- 4 weekly USS from 28 - 36W - Fasting glucose <7, trial diet and exercise then met then insulin - Above 7 metformin - above 6 plus macrosomia start insulin and metformin - Delivery 37-39W • 1st line - Diet management • 2nd line - If targets not met with 1st line after 1-2 weeks, offer metformin (insulin if contraindicated) - Insulin if pre-meal glucose >6 OR 1hr post-prandial glucose >7.5 • 3rd line - Targets not met with 1+2 then add insulin • Fasting glucose 6-6.9 and complications - Immediate insulin +/- metformin and diet
40
Targets for GDM blood sugars
- Fasting 5.3 - 1h after meal 7.8 - 2h after meal 6.4
41
Pre existing DM
- Folic acid pre pregnancy - Sliding scale needed in delivery - Planned delivery - Retinopathy screening
42
Shoulder dystocia
- Anterior shoulder of baby becomes stuck behind the pubic symphysis of the pelvis
43
Causes of shoulder dystocia
- Macrosomia secondary to GDM - Previous dystocia - Obesity
44
Presentation dystocia
- Failure of restitution - Turtle neck sign
45
Mx dystocia
- McRoberts manoeuvre = hyperflexion of hips - Suprapubic pressuer - Episiostomy - Rubins = reach into vagina put presure on anterior shpilder - wood screw = rotate baby
46
Dystocia complications
- Foetal hypoxia (cerebal palsy) - Brachila plexus injury and bells palsy - Perineal tears - PPH
47
HTN meds that should be stopped in pregnancy
- ACEi - Angiotensin receptor blockers - Thiazide diuretics
48
HTN meds safe in pregnancy
- Labetalol - CCB - Alpha blockers
49
What can undertreated or untreated hypothyroidism in pregnancy cause
- Miscarriage - Anaemia - Small for gestational age - Pre-eclampsia
50
Dose of levothyroxine in pregnancy
- Needs to be increased by 25-50mcg (30-50%) - Titrated based on TSH level = measured every 6 weeks - TSH lowers in pregnancy which is why dose increased
51
Epilepsy in pregnancy
- May worsen seizure control = stress, lack of sleep, hormones, altered medicines - Ideally should be controlled with single drug before coming pregnant
52
Safe epilepsy drugs
- Levetiracetam, lamotrigine, carbamazepine - SV avoid - Phenytoin avoid (cleft)
53
What is vasa praevia
- Foetal blood vessels run in the membranes in front of the presenting part - Vessels are placed over internal cervical os, before the foetus. therefore outside the protection of the cord or placenta
54
Vasa praevia presentation
- Painless, moderate vaginal bleeding at the rupture of the membranes - Severe foetal distress - USS - Antepartum haemorrhage - DVE = pulsating foetal vessels seen in membranes through dilated cervix
55
Vasa Praevia management
- Immediate C section - Asymptomatic - corticosteroids 32 weeks, elective CS
56
Type 1 and 2 Vasa Praevia
- Type 1 = foetal vessels are exposed as a velamentous umbilical cord - Type 2 = foetal vessels are exposed as they travel to an accessory placental lobe
57
When induction is offered
- Prelabour ROM - Foetal growth restriction - Pre eclampsia - Obstetric cholestasis - DM - IUFD - Bishop score 8 or more
58
Prostaglandin induction
- PGE2 inserted into vagina - Stimulated cervix and uterus to cause osnet of labour
59
Amniotomy +/- oxytocin
- ARM then oxytocin infusion started within 2 hours if labour not ensued
60
CRB
- Silicone balloon insetred into cervix and gently inflated to dilate
61
Why incidence of VTE is increased in pregnancy
- Blood clotting factors are increased - Fibrinolytic activity reduced - Blood flow altered - Stagnation of blood and hypercoagulable states
62
RF VTE in pregnancy
- Smoking - Parity >3 - Age >35 - BMI >30 - Reduced mobility - Multiple pregnancy - Pre ec - Varicose veins - FHx - Immobility - IVF
63
Pulmonary embolus
- Chest pain and dyspnoea - Tachy, raised RR and JVP - CXR, ABG and CT - CTPA or VQ
64
Prophylaxis DVT/PE
- from 28 weeks if 3 RF - 1st trimester if 4+ RF - LMWH continued throughout antenatal and for 6 weeks post - Temporarily stopped in labour - Mechanical if contraindicated LMWH = pneumatic compression, anti-embolism stockings
65
DVT
- Unilateral - Calf swelling - Dilated superficial veins - Tender calf - Oedema - Colour change - Ix = doppler USS
66
Mx VTE
- LMWH started immediately, before confirming diagnosis - Massive PE and haemodynamic compromise = unfractioned heparin, thrombolysis, surgical embolectomy
67
Risks of UTI in pregancy
- Preterm delivery - Low birth weight - Pre ec
68
Asymptomatic bacteriuria
- Bacteria in urine with no Sx - Tested routinely throughout pregnancy
69
Causes of UTI
- E coli most common - Klebsiella
70
Mx UTI
- 7 days abx - Nitrofurantoin (avoid in 3rd trimester) - Amoxicillin - Cefalexin - Trimethoprim avoid in early pregnancy
71
Cord prolapse
- After rupture of membranes, UC descends below presenting part
72
RF cord prolapse
- Preterm labour - Breech - Polyydramnios - Abnormal lie - Twins - amniotomy
73
Mx cord prolapse
- Pushed up by finger - Tocolytics can be given (terbutaline) - All fours - Immediate CS
74
Uterine rupture
- Muscle layer of uterus (myometrium) ruptures - Incomplete = perimetrium remains intact - Complete = perimetrium ruptures and contents of uterus released into peritoneal cavity
75
RF uterine rupture
- Previous CS = scar is a point of weakness - Previous surgery - BMI - Parity - Age - Induction
76
Rupture presentation
- Acutely unwell mother - Abnormal CTG
77
Rupture Mx
- Maternal resuscitation with fluids and blood required - Emergency CS - Repair or removal of uterus
78
Uterine inversion
- Fundus inverts into uterine cavity - Haemorrhage, pain and shock - Brief attempt to push fundus up into vagina - Replacement with hydrostatic pressure run past a clenched fist at the introitus into the vagina
79
Rubella in pregnancy
- Congenital rubella syndrome caused by maternal infection - Pregnant women should not be given MMR vaccine as it is live = need before or after Features of rubella syndrome - Congenital deafness - Congenital cataracts - Congenital heart disease - Learning disability
80
Chickenpox/VZV
- Foetal varicella syndrome = growth restriction, microcephaly, scars, hypoplasia - Severe neonatal varicella infection - Treat with IV varicella immunoglobulins
81
Triad of features of congenital toxoplasmosis
- Intracranial calcification - Hydrocephalus - Chorioretinitis
82
Complications of parovirus in pregnancy
- Miscarriage - Severe foetal anaemia - Hydrops fetalis - Maternal pre ec like syndrome
83
HSV in pregnancy
- Neonatal infection rare but high mortality - Vertical transmission at delivery - CS recommended - Exposed neonates given acyclovir
84
Neonatal effects HIV
- Stillbirth - Pre ec - Growth restriction - Prematurity - Vertical transmission
85
Group B strep
- Causes severe illness - Vertical transmission can be prevented by high dose IV penicillin throughout labour - RF = previous, positive culture, preterm labour, ROM >18hrs, maternal fever
86
Grounds for TOP
A = continuing would risk life of woman more B = necessary to prevent permanent injury to physical or mental health C = not exceeded its 24th week and continuance would be greater risk D = not exceeded 24th week and continuance would be greater to children E = risk that if child would suffer physical or mental abnormalities as to be seriously handicapped
87
Legal requirements for TOP
- 2 registered medical practitioners - Registered practitioner in an NHS or approved hospital
88
Medical TOP
- Mifepristone = anti-progestogen = halts pregnancy and relaxes cervix - Misoprostol = prostaglandin analogue = binds to prostaglandin receptors and activates them = soften cervix and stimulate contractions - Used together mif then miso 36-48hrs later - Rh -ve women should have anti D 10 w or above
89
Surgical TOP
- Cervix prepared first = misoprostol, mifepristone or osmotic dilators - Dilation and suction - Dilation and forcep evacuation
90
Complications TOP
- Haemorrhage - Infection - Uterine perforation - Cervical trauma
91
Adenomyosis definition
Presence of endometrial tissue inside the myometrium - Associated with endometriosis and fibroids
92
Adenomyosis S+S
Painful heavy periods, regular Dyspareunia 1/3 asymptomatic Exam = uterus mildly enlarged and tender, boggy
93
Adenomyosis Ix
- TVUSS - MRI
94
Adenomyosis Mx
No contraception wanted - TXA when no associated pain - Mefenamic acid when associated pain Contraception - Mirena coil - COP - Progesterone's
95
Atrophic vaginitis
- Dryness and atrophy of the vaginal mucosa related to lack of oestrogen - Occurs in women entering menopause = oestrogen falls and mucosa is thinner, less elastic, dry
96
Atrophic Vag S+S
- Itching and dryness - Dyspareunia - Bleeding due to localised inflammation Exam - Pale mucosa - Thin skin - Reduced folds - Erythema and inflammation - Dryness - Sparse pubic hair
97
Atrophic Vag Mx
- Lubricant - Topical oestrogen
98
Causes of infertility
- Ovulation issues - Male factor problems - Sperm unable to reach egg = tubal, coital, cervical - Implantation
99
General advice for fertility
- 400mcg folic acid a day - Health = BMI, smoking, alcohol - Intercourse every 2-3 days
100
Primary care Ix infertility
- BMI - Chlamydia screen - Semen analysis - Female hormone testing - Rubella immunity
101
Female hormone testing infertility
- Serum LH and FSH days 2-5 of cycle - Serum progesterone on day 21 of cycle - Anti mullerian hormone - TFTs - Prolactin
102
Female hormone testing infertility results
- High FSH = poor ovarian reserve - High LH = PCOS - Rise in progesterone day 21 = ovulation - AMH = high = good ovarian reserve
103
Fertility Ix in secondary care
- USS pelvis - Hysterosalpingogram - Laparoscopy and dye test
104
Mx anovulation
- Weight loss - Clomifene to stimulate ovulation or letrozole - Gonadotrophins - Ovarian drilling
105
IUI
- for unexplained subfertility, cervical, sexual and some male factors - Sperm injected directly into cavity of uterus
106
IVF
- Embryos fertilised outside uterus and transferred back - Normal ovarian reserve needed
107
Menopause
- Retrospective diagnosis made after a woman has had no periods for 12 months
108
Menopause physiology
- Decline in development of ovarian follicles and without there is a reduced production of oestrogen - Oestrogen and progesterone levels are low - Therefore LH and FSH levels are high, in response to an absence of negative feedback from oestrogen
109
Perimenopause
- Vasomotor symptoms and irregular periods - Hot flushes - Emotional lability - PMS - Joint pains - Period variation - Dryness and atrophy - Reduced libido
110
Risks associated with menopause
- OP = effects reliably reversible with oestrogens - CVD = adverse changes in lipid, increased prevalence with early menopause - Dementia = increased prevalence with early menopause
111
HRT risks
- Breast cancer - VTE = oral>transdermal - CVD - Stroke (oral)
112
HRT
- Progesterone should be used for at least 12-14 days every 4 weeks = protects endometrium from unopposed oestrogen - Oestrogen = oral, patch, gel, vaginal, implant
113
Who should have transdermal HRT
- GI upset - Need for steady absorption = migraine, epilepsy - Perceived increased risk VTE - Older women - Medical conditions - Choice
114
Lichen sclerosis
- Chronic inflammatory skin condition that presents with patches of shiny white skin - Affects labia, perineum and perianal skin - Autoimmune condition associated with DM, alopecia, hypothyroid and vitiligo
115
Lichen Sclerosis S+S
- Itching - Skin changes - Soreness (may worse at night) - Skin tightness - Superficial dyspareunia - Erosions - Fissures - Koebner phenomenon = worse by friction
116
Lichen Sclerosis Mx
- Potent topical steroids = clobetasol propionate 0.005% (dermovate) - Emollients
117
For what maximum period following termination is positive test normal
4 weeks
118
HELLP syndrome
- Haemolysis - Elevated Liver enzymes - Low platelets - Usually jsut after birth
119
S+S HELLP
Headache Nausea and/or vomiting Epigastric pain Right upper quadrant abdominal pain due to liver distention Blurred vision Peripheral oedema Mx = delivery
120
Transient tachypnoea newborn
Hyper inflated lungs and fluid C section Respiratory distress Oxygen support
121
Requirements for instrumental delivery
Fully dilated and in 2nd stage OA presentation Ruptured membranes Cephalic presentation Engaged head Pain relief Sphincter empty
122
Hyperemesis gravidarum
- More than 5% weight loss compared to before pregnancy - Dehydration - Electrolytes
123
hyperemesis investigations
- PUQE score = <7 mild, 7-12 moderate, >12 severe - Urine dip = ketones - Bloods
124
When to admit Hyperemesis G
- unable to tolerate oral antiemetics or keep fluids down - More than 5% weight loss - Ketone urine - Other med conditions
125
Mx Hyperemesis G
- IV or IM antiemetics - IV fluids = normal saline with KCL - U+E monitoring - Thiamine supplementation to prevent deficiency - Thromboprophylaxis Prochlorperazine (stemetil) Cyclizine Ondansetron Metoclopramide
126
RF for ectopic
- PID - Tubal damage - Previous ectopic - Over 35 - Smoking - Ectopic whilst pregnant
127
S+S ectopic
- Lower abdo pain - Scant dark vaginal bleeding - Colicky then constant pain - Syncopal episodes and shoulder tip pain - Amenorrhoe 4-10 weeks
128
Ix ectopic
- Tachycardia, tender abdo - Cervical excitation - Pregnancy test - USS TV = GOLD - laparoscopy
129
Mx ectopic
- Medical = methotrexate (no sig pain, <35mm, hCG <1500) - Surgical = salpingectomy or salpingotomy (>35mm, FHR, hCG >5000)
130
PPH definition
- Primary = loss of >500ml <24 hrs after - Secondary = 24hrs - 12 weeks after - Minor = <1000ml - Major >1000ml
131
Aetiology PPH
- Tone = uterine atony - Trauma - Tissue = retained placenta - Thrombin = bleeding disorder
132
RF PPH
- Tone Trauma Tissue Thrombin - Antepartum haemorrhage - Coag defect - Instrumental delivery - Multiparity - Obesity
133
Mx PPH
- ABCDE - 2 large bore cannulas - Fluid resus - Oxytocin/bolus infusion - Ergometrine - Haemobate/carboprost - TXA - Massage uterus - Catheter - Bimanual compression - Misoprostol PR - Surgery = rusch balloon, b lynch, ligation, hysterectomy
134
PPH prevention
- Anaemia antenatally treated - Give birth with empty bladder - Active Mx 3rd stage = IM oxy - IV TXA
135
Placenta praevia definition
- Implanted in lower segment of uterus - Major = lies over cervical internal os - Minor = leading edge of placenta in lower uterine segment, not covering os
136
S+S Placenta Praevia
- Intermittent painless bleeds - Increase in severity and frequenct over several weeks - Breech or transverse
137
Placenta Praevia Ix
- NEVER vaginal exam - 20 week scan = repeat at 32 and 36 - TV USS
138
Placenta Praevia Mx
- ABCDE - bloods - IV access - Steroids if <34 - Planned delivery - CS if placental edge <2cm from internal os
139
Placental abruption definition
Part or all of the plcenta separated before delivery of foetus
140
Abruption RF
- IUGR - Pre ec - HTN - Smoking or cocaine use - multiple pregnancy
141
S+S Abruption
- painful bleeding due to blood behnd placenta and in myometrium - Dark blood - Hypotension and tachycardia - Woody abdo, tender - CTG distress
142
Abruption Mx
- ABCDE - FBC, coag, cross match - Catheterisation - Steroids <34 weeks - IV access, fluids and bloods - Foetal distress = urgent delivery CS - >37 weeks, no distress = induce via amniotomy - Preterm and no distress = steroids
143
Adherent placenta
- Accretta = chorionic villi attach to myometrium rather than being restricted in decidua basalis - Increta = chorionic villi invade myometrium - Percreta = invade through myometrium
144
Preterm prelabour rupture of membranes
- Speulum exam = pooling fluid - IGFBP1 +ve - Proph abx = erythromycin 250mg 4XD for 10 days = prevent chorioamnionitis - Induction 34 week
145
Ovarian torsion S+S
- Acute severe pelvic or abdo pain, unilateral and constant - N+V - Palpable abdo mass - Feeding intolerance - Strenuous exercise - Peritoneal signs - Cervical motion tenderness - Fever
146
Ovarian torsion Ix
- Clinical suspicion - TV USS = whirlpool sign, free fluid and oedema - Preg test
147
Mx torios
- Laparoscopic surgery - Oophorectomy
148
Prolapse RF
- Vaginal delivery - Congenital factors - Menopause - Chronic cough, constipation, heavy lifting - Obesity
149
S+S Prolapse
- Dragging sensation - Worse standing or end day - Intercourse disruption - Ulceration - Urinary frewuency and incomplete bladder emptying - Stress incontinene - Rectocele
150
Ix prolapse
- Abdo exam - Sim speculum - Urine dip - Bladder diary - USS if mass suspected
151
Prolapse mx
- weight loss - physio - pessary - hysteropexy - anterior repair - sacrospinous fixation - colpocleisis
152
Urethrocele
- Lower anterior wall inolving urethra
153
Cystocele
upper anterio vaginal wall involving bladder
154
Pathophysiology PCOS
- Disordered LH production and peripheral insulin resistance - Raised LH and insulin = increased ovarian androgen production - Raised insulin = increased adrenal androgens and reduce hepatic SHBG = increased free andorgens - Increased intraovarian androgens disrupt foliculogenesis
155
S+S PCOS
- oligo or amennorhoea - infertility - obesity - hirsutism - acne - hair loss - DM - acanthosis nigria=cans - high cholesterol - sleep apnoea - depression and anxiety
156
PCOS IX
- Testosterone (-/up), SHBG (-/low), LH (-) - free androgen index - raised LH:FSH ration - Pelvis and TV USS + GOLD = 12 or more developing follciels in 1 ovary, string of pearls
157
PCOS Mx
- Reduce risks associated with obesity - Mirena coil - withdrawal bleed with cyclical progestogens
158
Presentation of ovarian cysts
- Pelvic pain - Bloating - Full abdo - Palpable mass
159
Functional cysts
- Follicular = thin walls and no internal structures, developing follicle - Corpus luteum = fills with fluid instead of breaking down = pelvid discomfort, pain, delayed menstruation
160
primary neoplasms
- Epithelial tumours = PM wome - Germ cell tumours = benign, teratomas/dermoid = young pre menopause, teeth and tissue
161
Ix cysts
- Pre menoapusal with <5cm cyst = no need ix - CA125
162
cyst mx
• Dermoid = gynaecologist • Simple ovarian <5cm = leave to resolve • 5-7cm = routine gynae referral and yearly USS • <7cm = MRI or surgical evaluation
163
Fibroids
benign tumours of myometrium/smooth muscle grow in response to oestrogen
164
S+S fibroids
- HMB - IMB - Dysmenorhoea - Urinary frequency - Bloating - Dyspareunia
165
fibroids ix
- hysteroscopy if submucosal - pelvic uss - mri
166
mx fibroids
- <3cm = same as HMB = Mirena coil, NSAIDS and TXA, COP - Smaller fibroids with HMB = endometrial ablation, resection, hysterectomy - >3cm = same as above along with myomectomy - GnRH agonists can reduce size of fibroids before surgery = induce a menopausal like state and reduce amount of oestrogen maintaining the fibroid
167
RF PID
- STI - Unprotected sex with multiple partners - recent instrumentation
168
S+S PID
- uterine tenderness - lowe abdo paon - abnormal discharge - abnormal bleeding - RUQ pain - Dysmennorhoea - Subfertility - Dyspareunia - Adnexal and CM tenderness
169
Ix PID
- swabs - wbc, crp - pelvic uss - laparoscopy
170
mx pid
- analgesia - cephalosporin - remove iud - 500mg ceftriaxone IM - Doxy 100mg BD and met 400mg BD for 14 days
171
Dichorionic diamniotic
- 2 separate placentas and 2 separate sacs - membrane between twins with a lamba or twin peak sign in USS - Best outcomes
172
Monochorionic diamniotic
- single placenta but 2 sacs - Membrane between twins = T signs USS
173
Monochorionic monoamniotic
- Single placenta and single sac - No membrane separating the twins
174
twin-twin transfusion syndrome
- Happens when share placenta - 1 foetus may recieve majority of blood while other is starved - Recipient gets majority of blood and can become fluid overloaded = HF and polyhydramnios - Doner = GR, anaemia and oligohydramnios - Tertiary specialist foetal medicine centre - Laser treatment can be used to destroy conenction between 2 blood supplies
175
Twin anaemia polycythaemia sequence
- Less acute than transfusion syndrome - 1 anaemic and other polychythaemic
176
Antenatal care multiple pregnancies
Additional monitoring for anaemia at: - booking - 20 weeks - 28 weeks USS - 2 weekly from 16w for monochorionic - 4 weekly from 20w for dichorionic
177
when to investigate infertility
trying to conceive without success for 12 months or 6 if >35 and ovarian stores likely reduced
178
Causes of infertility
- Ovulatory disorders - Tubal damage - Male infertility - Uterine or peritoneal disorders - 25% unknown
179
Ovulation disorders
- Group 1 = hypogonadotrophic hypogonadism = hypothalamic pituitary failure - Group 2 = dysfunctions of hypothalamic-pituitary ovarian axis (PCOS) - Group 3 = ovarian failure = high gonadotrophins and hypogonadism
180
pre testicular causes infertility
- Pathology of pituitary gland or hypothalamus - Suppression due to stress, chronic conditions or hyperprolactinaemia -Kallman
181
Post testicular causes
- Damage to testicle or VD - Ejaculatory duct obstruction - Retrograde ejaculation - Scarring - Absence of VD - Young's syndrome
182
Female hormone testing
- Serum LH and FSH on day 2-5 - High FSH = poor ovarian reserve - High LH = PCOS - Serum progesterone on day 21 - AMH = ovarian reserve - TFT - Prolactin
183
Anovulation mx (PCOS)
- weight loss - clomifene - letrozole - gonadotrophins - ovarian drilling in pcos
184
S+S ovarian hyperstimulation
- Abdo pain and bloating - N+V - Diarrhoea - Hypotension and hypovolaemia - Ascites - Pleural effusions, renal failure, prothrombic state
185
S+S cervical cancer
- Abnormal bleeding - Vaginal discharge
186
Cervical screening
- Detects pre malignant screening - Sample is tested for high-risk strains of HPV 1st and cytology only if positive - 25-49 = 3 years - 50-64 = 5 years
187
Negative hrHPV
- return to normal recall
188
Positive hrHPV
- Cytology - Abnormal cytology = colposcopy - Normal cytology = repeat at 12 months = if the -ve return to normal. If now +ve and cytology still normal = further tests 12 months later (same process)
189
Ovarian cancer
- Vague S+S = bloating, pain, urinary - NICE = CA125 done initially and if raised do USS - Surgery and chemo
190
IUGR
- <10th centile Asymmetrical - Extrinsic factors - Maternal conditions - Pregnancy conditions - Later stages - 70% of IUGR Symmetrical - Intrinsic factors - Global growth restriction - Increased risk neuro sequalae
191
Maternal sepsis
- Temp <36 or >38 - Tachycaedia >90 - Tahcypnoea = RR >20 - WCC >12 or <4x10 - Hyperglycaemia >7.7
192
Post dural headache
- Headache worse on sitting or standing - Neck stiff - Avoid lights - Lie flat - Simple analgesia - Epidural blood patch
193
stress incontinence S+S
- Coughing - Sneezing - Effort - Exercise
194
Urge incontinence S+S
- Overactive bladder - Sudden urgency - Frequency - Nocturia
195
Incontinence Ix
- Dipstick - Vaginal examination - Bladder diary
196
Urge Mx
- Bladder retraining - Antimuscarinic drugs - Invasive mx
197
Stress mx
- Pelvic floor training - Duloxetine - Surgery
198
USS findings for miscarriage
- Heartbeat = viable pregnancy - Heartbeat expected when crown-rmp length 7mm - <7mm CR lenght and no HB = repeat after 1 week - CL >7mm and no FHB = 1 week again before confirming - If mean gestational sac diameter of 25mm+ and no foetal pole = after 1 weeks
199
Miscarriage mx <6w gestation
- Expectant mx if no pain - Repeat urine after 7-10 days
200
Miscarriage >6w gestation
- EPAU = USS - Expectant - Medical = misoprostol - Surgical
201
Incomplete miscarriage mx
- Misoprostol or surgery
202
Primary amennorhoea
- hypogonadic hypogonadism = decreased LH and FSH leads to decreased oestrogen= damage to pituitary, exercise, Kallman's - hypergonadic hypogonadism = turners = increased LH and FSH but decreased oestrogen - not started by 13 and no development - CAH = decreased cortisol and aldosterone
203
Causes of menorrhagia
- Dysfunctional uterine bleeding - Fibroids - Endometriosis and adenomyosis - PID - Contraception - Bleeding disorders - PCOS
204
Ix menorrhagia
- Pelvic exam = spec and bimanual - FBC - hysteroscopy if submucosal fibroids, endometrial pathology or persistent IM bleed - USS = palpable mass, adenomyosis, hard to interpret exam
205
Ix fibroids
- Hysteroscopy if submucosal and HMB - Pelvis USS if large - MRI beofre surgeyr
206
Mx fibroids
- <3cm = mirena, TXA - smaller surgery = ablation, resection - >3cm = gynae referral = mirena, surgery - GnRH agonists used before surgery
207
Asherman's syndrome S+S
- Secondary amennorhoea - Lighter periods - Dysmenorrhoea
208
Asherman's ix
- hysteroscopy - hysterosalpingography - sonohysterography - MRI scan
209
Ectropion
- columnar epithelium of endocervix extends to ectocervix - Postcoital bleed due to fragility - associated with high oestrogen levels - o/e = well demarcated border between columnar epithelium from os and pale pink squamous epitheloim of ectocervix - cauterisation of problematic
210
FGM
- Mandatory to report all cases <18 to police - If unborn child of a pregnant woman at risk referral should be made
211
Androgen insensitivity S+S
- Inguinal hernias - Primary amenorrhoea - Raised LH, normal/raised FSH, raised testosterone and oest in males - Bilateral orchidectomy and oestrogen therapy
212
Complete mole
- 2 sperm cells fertilise an empty ovum = sperm combine genetic material and divide and grow
213
Partial mole
- 2 sperm cells fertalise normal ovum = haploid cell and multiplies
214
Ix molar pregnancy
- More severe morning sickness - Vaginal bleeding - Increased enlargement of uterus - Abnormally high hCG - Thyrotoxicosis - USS = snowstorm
215
Failure to progress
- Power - Passenger - Passage
216
3 phases of 1st stage
- Latent = 0-3cm = 0.5cm/hr - Active = 3-7cm = 1cm/hr - Transition = 7-10cm = 1cm/hr Delay = <2cm in 4hrs or slowing of progress in multiparous woman
217
2nd stage
- 10cm - delivery of baby - Delay = pushing over 2hrs in nulli and 1hr in multi - Power = give oxytocin - Passenger, presentation and passage
218
3rd stage
- Delivery of baby to delivery of placenta Delay - >30m with active mx - >60m with physiological mx
219
Postpartum endometritis
- inflammation of the endometrium - Usually caused by infection - common after cs so proph abx given
220
S+S endometritis
- Foul smelling discharge or lochia - Bleeding that gets heavier or doesnt improve with time - Lower abdo pain - Fever - Sepsis
221
Postpartum anaemia
- Hb <100g/l = oral iron 3Xd for 3m - <90 = consider iron infusion and oral - <70 = iron infusion and oral
222
Mx mastitis
- Conservative = warm showers and analgesia - infection - flucloxacillin or erythromycin - Continue breastfeeding
223
Postpartum thyroiditis
- Changes in thyroid function within 12m delivery - Thyrotoxicosis, hypothyroidism or both
224
Stages of thyroiditis
- thyrotoxicosis - first 3m - hypothyroid 3-6m - gradually return to norml
225
S+S thyrotoxicosis
- anxiety and ittitability - sweating and heat intolerance - tachycardia - wl - frequent loose stool - raised T34 and suppressed TSH
226
S+S hypothyroidism
- Wight gain - fatigue - dry skin - coarse hair - low mood - fluid retention - T34 low and tsh high
227
thyroiditis mx
- 6-8w TFTs thyrotoxicosis = symptoms control with propranolol - hypothyroid = evothyroxin
228
Sheehans syndrome
- Complication of PPH - Dopr in circulating BP leads to avascular necrosis of pituitary gland - only affects anterior pituitary
229
Sheehans presentation
- Reduced lactation - amennorhoea - Adrenal insufficiency and adrenal crisis - hypothyoirism and low thyroid hormones
230
Mx sheehans
- replacement of missing hormones
231
Asymptomatic baceteruria mx
- nitrofurantoin - amoxicillin - cefalexin
232
POPQ grading
0 = normal 1 = lowest part more than 1cm above introitus 2 = lowest part within 1cm introitus 3 = lowest part >1cm below but not fully descended 4 = full descent with eversion of vagina Beyond introitus = uterine procindentia
233
foetal hydrops
- abnormal accumulation of serous fluid in 2+ foetal compartments - Immune or non-immune causes
234
Non immune causes FH
- Severe anaemia - Cardiac abnormality - Csome disorders - Infection - twin twin transfusion - Chorioangioma
235
DR C BRAVADO
DR = define risk C = contractions BRA = baseline rate = 110-160bpm V = baseline variability = 5-25bpm A = accelerations = 15 lasting 15s+ D = decelerations = 15 for 15 O = overall impression
236
Breech Mx
- ECV from 37 weeks = tocolysis first - Vaginal or CS
237
What is a kleihauer test
- quantifies how much foetal blood is mixed with maternal blood to determine dose of anti D required
238
Rotterdam criteria trio PCOS
At least 2 of - oligoovulation or anovulation - Hyperandrogenism - Polycystic ovaries on USS
239
When to doe expectant in ectopic
- Unruptured - Adnexal mass <35mm - No visible heartbeat - No significant pain - HCG <1500 iu/l
240
Methotrexate in ectopic pregnancy
- HCG <5000 - Confirmed absence of intrauterine pregnancy on USS
241
Surgery for ectopic
- Pain - Adnexal mass >35mm - Visible heartbeat - HCG >5000 iu/l - Salpingectomy 1st line - Salpingotomy to preserve fertility
242
Urge incontinence
- overactive bladder - sudden need to wee and rush to loo but incontinent before get there - Bladder retrain - Anticholinergic = oxybutynin - Surgery
243
Stress incontinence
- Weakness of pelvic floor - Urinary leakage when laugh, cough etc. - Avoid caffeine, diuretics and overfill - Weight loss - PF exercises - Surgery or duloxetine
244
Incontinence Ix
- Bladder diary - Dipstick - Post void bladder volume - Urodynamic testing (urge not responding to 1st line)
245
Mixed mx
- Manage according to most predominant type of incontinence
246
First degree tear
- Frenulum of labia minora and suoerficial skin - no suture
247
2nd degree tear
Includes perineal muscles but not anal sphincter - on ward
248
3a tear
- fascia and muscles of perinium and <50% external anal sphincter - theatre
249
3b tear
- fascia and muscles of perineum and >50% anal sphincter
250
4 tear
- external and internal anal sphincters torn and anal epithelium - rectal mucosa
251
Erbs palsy affects...
C5-6
252
Bishop score
- Foetal station - Cervical position - Cervical dilatation - Cervical effacement - Cervical consistency - 8 or more = spontaneous 4
253
RF for ectopic
- previous - ID - surgery - coil - older age - smoking - endometriosis - IVF - POP - anything that slows egg movement
254
Mx menorrhagia if contraception wanted
- Mirena - COP - POP
255
Mx menorrhagia if no contraception
- TXA - mefenamic
256
Downs combined test
- 12 weeks - USS for NT = >6 - BHCG = high - PAPPA = low
257
Down quadruple test
- 14-20w - BHCG = high - AFP = low - Oestriol = low - Inhibin A = high
258
CVS downs
- before 15w - 1/11 miscarriage
259
Amniocentesis
- 15-20w or alter - 1/200 miscarriage
260
when is vaginal progesterone given in premature labour
- cervical length <25mm between 16 - 24w
261
when is cervical cerclage given
- cervical length <25mm between 16-24 - previous premature birth or cervical trauma
262
Abx given in prom
- erythromycin 250mg 4xday for 10 days
263
Gillick competence
- <16 can consent to own medical treatment
264
Fraser competence
- <16 and contraception
265
high RF for pre ec
- previous preg - CKD - autoimmune - DM - chronic htn 1+ = aspirin
266
moderate RF pre ec
- 1st preg - 40+ - pregnancy interval 10 yrs - BMI 35 - FHx - multiple preg - 2+ = aspirin
267
who takes 5mg folic acid
- on anti-epileptic - coeliac disease - DM - BMI >30 - neural tube defect take until 12 weeks
268
When do you measure peak progesterone levels?
7 days before the start of next period e.g. if someone has a 7/28 cycle measure progesterone on day 21