Obstetrics Flashcards
(118 cards)
When are health preggo women going to have routine scans?
10-14 weeks dating scan
18-21 week anomaly scan
What screening are women routinely offered?
- fetal anomalies (down syn opt in. and ALL women anomaly scan at 18-21 wks)
- Infectious diseases (HIV, Heb B, syphillis, rubella)
- Rh-ve
- Hb globinopathies
What prenatal diagnostic tests are offered? Indications for these tests?
- Chorionic villus sampling (+11wks) = inc risk of miscarriage
- Amniocentesis (15wks)
- Suspected chromosomal abnormality, NTD, abnormal maternal serum analyte
- Age > 35
- Previous child with congenital abnormality
- One of the parents has a chromosomal abnormality or other FHx
Maternal serum sampling at 11wks detects which hormones?
hCG (inc in downs and tri 18)
PAPP-A (preggo assoc plasma protein A) - Dec in down and Tri 18
Quadruple screening occurs when and includes which hormones?
15-20wks
- hCG = inc in downs
- Estriol (E3) = dec in downs and tri 18
- AFP (NTD)
- Inhibit A = inc in downs
What ultrasound scan is performed between 11-14 weeks and what does it look at?
CRL (accurate at measuring gestational age) - better than biparietal or femur length
Nuchal translucency (thickness of subcut tissue in nuchal region. > 3mm assoc with CV defects, and downs)
All women receive this scan at 20 weeks. what is it and what does it include?
Anomaly scan between 18 and 26 was.
- Looks for list of conditions (anencephaly, myelomeningocele, gastrochisis, cleft lip, heart defects)
- Head circus, abdo circum, femur length,
(macro or microsomia)
Rh-ve mum with rh-ve child = problem?
Rh-ve mum with 2nd rh+ve child = problem?
Rh-ve mum with 1st rh+ve child = problem?
Rx?
No to a rh-ve child and Not really problem if first pregnancy rh+ve but still offered treatment
If rh+ve child on second preggo, then sensitisation to the Rh+ve may have occurred in the mum to produce IgG Abs which can cross the placenta unlike in the first preggo where IgM Abs can not cross.
- If antigens from Rh+ve on 2nd preggo, enter maternal circulation, IgG response will occur.
The IgG Abs can cause haemolysis of the fetal RBC can haemolytic disease of the newborn.
Treatment is to give all Rh-ve women anti-D Ig IV at 28-30 days
= neutralises foetal Rh+ve antigens which would have entered the maternal blood leading to IgG production
IM injection of anti-D given after baby is delivered
What is hyperemesis gravidarum?
Excessive N&V of pregnancy such that women can not maintain adequate hydration and lose wt ( >2-5kg)
Peak onset and clinical features of hyperemesis gravidarum? Effect on foetus?
1% of preggos.
6-11wks
N&V Excess salivation Reduced urine output and epigastric pain Signs of dehydration inc ketones in urine and liver tenderness
If >10% wt loss then foetus could be restricted in growth.
In which trimester is heartburn more prevalent?
Adv to women?
What must you also be concerned about with epigastric tenderness?
Third trimester (70%). Reassure.
Adv low fat set, bland foot, small portions.
Adv against later night food. Adv raising head at night.
Avoid gastric irritants (caffeine)
Anatacids (magnesium trisilicate) = if lifestyle mods are ineffective.
Consider pre-eclampsia if unresponsive to simple antacids. Check BP and protein.
What are you likely to see on blood tests in hyperemesis?
Raised hCG. Raised TFTs without signs suggestive of hyperthyroidism. Inc urea if dehydrated. Electrolyte disturbances.
Check UandEs, LFTs, TFTs
Prevalence of Nausea in preggo?
Vomit in preggo?
Associated with?
N >80% from 4-6wks. should ease by 14-16wks.
V 50%
Any time of the day.
Odours and preparation/sight of food.
Mx of N&V, and hyperemesis gravidarum?
Reassure.
Exclude other causes of vomiting such as UTI, thyrotoxicosis.
Adv small, frequent fluid and small amounts of carbs.
Self help = ginger and P6 acupressure
If dehydrated, and not tolerating oral intake = admit. Consider IV rehydration.
Antihistamine antiemetics such as cyclizine work best.
If prolonged, Vitamin B supplementation may be needed as Wernickes encephalopathy has been reported. High dose Corticosteroids may of benefit if severe.
Prevalence of constipation in preggo?
Rx?
40%
Inc fluid and fibre intake.
If necessary use a bulk forming laxative such as ispaghula husk (avoid stimulants as these inc uterine activity)
Prevalence of backache in preggo?
60%. worse in evenings. adv light exercise unless CI (pre-eclampsia)
What does HELLP stand for?
Haemolysis and elevated liver enzymes with low platelet count.
Variant of pre-eclampsia
How would you categorise high risk pregnancies?
Maternal conditions
- Obesity, DM, HTN
- chronic (renal, cardiac, endocrine, haem, AI), epilepsy
- Infections (HIV, HepB)
Social factors
- Maternal age > 40 or < 18
- Multiparous (inc risk of PPH) = Para > 6 or > 3 miscarriage
- Smoker, domestic violence, substance abuse
Obstetric issues in previous preggo
- Previous C-section
- Previous preterm delivery, still birth, death
- Pre-eclampsia, Eclampsia, HELLP
- Previous GDM
- Previous tears
- Previous psych illness
Problems in this preggo
- Multiple preggo
- Small or large for gestational age
- Placenta previa
- GDM
- pre-eclampsia
What are the four major mechanisms responsible for preterm labour?
Stress (maternal or foetal)
Infection (IU)
Stretch (excessive due to multiple preggo, polyhydramnios)
Haemorrhage (decidual = placental abruption)
Main causes of preterm labour?
PPROM
Intra-amniotic infection/inflammation
Idiopathic
Difference between PROM and PPROM?
PROM = premature rupture of membranes before onset of labour
PPROM = preterm premature rupture of membranes < 37wks
Absolute contradictions to the use of tocolytics?
Tocolytics = suppress uterine contractions
Indications = prolongation of preggo is beneficial for lung maturity etc.
CI
- APH
- Infection (evidence of chorioamniotitis = maternal pyrexia, uterine tenderness, raised WCC, CRP, foetal tachy)
- Foetal distress
- IU foetal demise
Caution in those with DM as betamimetics inc gluconeogenesis and therefore precipitate a DKA.
PPROM is a relative CI
Preggo lady at 31 wks presents and has suspected preterm labour. No CI. Mx?
Tocolytics
- Nifedipine (calcium channel blocker) 1st line
SE hypoTN, reflex tachycardia, nausea, headache, hepatotoxicity
- if nifedipine CI, then oxytocin receptor antagonists (atosiban)
SE N, headache, chest pain, arthalgia
Maternal corticosteroids
Magnesium sulphate for neuroprotection
Absolute indications for a C-section?
Maternal
- failed induction
- failure to progress
- cephalopelvic disproportion
Utero-placental
- Previous uterine surgery
- previous uterine rupture
- Outflow obstruction (fibroids)
- Placenta previa/large placental abruption
Foetal
- foetal distress
- cord prolapse
- foetal malpresentation (transverse lie)