OBSTETRICS Flashcards
In what context is use of prostaglandins for cervical ripening contraindicated?
History of prior C-seciton –> risk of uterine rupture
What antibiotics are use for pPROM and why?
Ampicillin/erythromycin –> shown to prolong latency period by 5-7 days
What antibiotics are used for chorioamnionitis?
Clinda/gent
MOA of Hemabate? Contraindication?
PGF2a, potent SM constrictor that can cause bronchospasm –> contraindicated in asthma
MOA of Methergine? Contraindication?
Alkaloid SM constrictor contraindicated in HTN or pre-E
What conditions are late and postterm pregnancies associated with?
Macrosomia Oligohydramnios Uteroplacental insufficiency Meconium aspiration Dysmaturity
What does progesterone < 5 indicate?
Abnormal or extrauterine pregnancy
Trend in B-hCG during pregnancy?
Doubles q2days until 42 days old
Criteria that needs to be met before MTX for ectopic?
- Hemodynamic stability
- Non-ruptured
- Mass < 4cm and no FHR OR < 3.5 cm with FHR
- Normal LFTs and renal function
- Reliable patient F/U
Common tests in patient with hx recurrent abortions (first trimester losses)?
Lupus anticoagulant, anticardiolipin, DM, thyroid dz
When should cervical cerclage be placed?
14 wks
What type of contraception helps decrease risk of developing ovarian and endometrial cancers?
OCPs
First developed HIGH dose OCPs have been linked to slight increase in breast cancer but most recent lower dose OCPs are not.
How are progesterone IUDs regarding cancer?
May decrease endometrial cancer risk but does nOT affect risk of ovarian cancer (vs. OCPs which decrease both risks)
How long does unpredictable bleeding last for Depo-Provera shot?
2-3 months
Most minimally invasive means for pregnancy termination?
PGE1 (mifepristone + miso-rostol)
GA cutoff for vacuum-aspiration for pregnancy termination?
<8weeks
Complication specifically associated with LEEP?
Cervical stenosis
How to make diagnosis of hypothalamic-pituitary amenorrhea?
FSH level–expected to be low
Treatment for hirsutism?
OCPs +/- spironolactone
Leuprolide or depo (NOT on OCPs)
How do LH levels change in PCOS? How does this affect androgen production?
Increased in pulsatile manner –> increased ovarian production of androgens by theca cells in ovaries
What do you expect on pathology for fibroids?
Well-circumscribed, non-encapsulated myometrium
Where is estrogen produced in postmenopausal women?
NOT ovaries.
Extraglandular conversion of androstenedione and testosterone to estrogen in peripheral fat cells.
Post-menopausal ovaries, however, are known to produce androgens!