Obstetrics Flashcards
(291 cards)
cWhat are the different drugs for:
Termination
Ectopic
Miscarriage
Termination = Mifepristone
Ectopic = Methotrexate
Miscarriage = Misoprostol
WHAT IS PRE-ECLAMPSIA?
Hypertension and proteinuria during pregnancy normally seen after 20 weeks
What are the high risk and moderate risk of developing pre-eclampsia?
- *High risk factors**
- Hypertensive disease in a previous pregnancy
- Chronic kidney disease
- Autoimmune disease, such as systemic lupus erythematosus or antiphospholipid syndrome
- Type 1 or type 2 diabetes
- Chronic hypertension
- *Moderate risk factors**
- First pregnancy
- Age 40 years or older
- Pregnancy interval of more than 10 years
- Body mass index (BMI) of 35 kg/m² or more at first visit
- Family history of pre-eclampsia
- Multiple pregnancy
What are the prevention methods for pre-eclampsia?
Why is this offered?
When is this offered?
- Low does aspirin 75mg
- >=1 high risk factors
- >=2 moderate
- Normally commenced at 12 weeks but before 16 weeks
What are the symptoms of pre-eclampsia?
- Headache
- Visual disturbance
- Epigastric and right upper quadrant pain
- Nausea and vomiting
What is the diagnosis of pre-eclampsia?
- BP >140/90
- FBC - High Hb
- Increase urea and creatinine
- Increase lactate dehydrogenase
What are the complications of pre-eclampsia?
- Eclampsia
- HELLP
- Cerebral haemorrhage
What are the categories of hypertension in pregnancy?
Pre-existing hypertension
Pregnancy-induced hypertension
Hypertension, no proteinuria or oedema
Pre-eclampsia
Hypertension, proteinuria and oedema
What is the treatment of pre-eclampsia?
>140/90
Oral labetalol hydrochloride
If not tolerated then nifedipine
>160/110
Admit to hospital
IV labetalol hydrochloride
Aiming for 135/85 mmHg
WHAT IS HELLP SYNDROME?
- Haemolysis
- Elevated liver enzymes
- Low platelets
Manifestation of pre-eclampsia
What are the symptoms of HELLP syndrome?
- Nausea & vomiting
- Right upper quadrant pain
- Lethargy
What is the treatment of HELLP syndrome?
Delivery of the baby
What should you do if a woman is past 37 weeks and is showing signs of pre-eclampsia?
IV magnesium sulphate and arrange for delivery of the baby
WHAT IS ECLAMPSIA?
Presence of tonic-clonic seizures in assocaited with a diagnosis of pre-eclampsia
What is the treatment of eclampsia?
- Magnesium sulphate is used to both prevent seizures in patients with severe pre-eclampsia and treat seizures once they develop
- Should be given once a decision to deliver has been made
- In eclampsia an IV bolus of 4g over 5-10 minutes should be given followed by an infusion of 1g / hour
- Urine output, reflexes, respiratory rate and oxygen saturations should be monitored during treatment
- Respiratory depression can occur: calcium gluconate is the first-line treatment for magnesium sulphate induced respiratory depression
- Treatment should continue for 24 hours after last seizure or delivery (around 40% of seizures occur post-partum)
When should magnesium treatment be stopped in eclampsia treatment?
Treatment should continue for 24 hours after last seizure or delivery (around 40% of seizures occur post-partum)
What is the treatment for respiratory depression caused by magnesium sulfate?
Calcium gluconate
What is the best anti-epileptic used in pregnancy?
Lamotrigine
WHAT IS ESSENTIAL HYPERTENSION?
Hypertension with no secondary cause identified >140/90mmHg
What are the risk factors for essential hypertension?
Genetic variation
Aging
Obesity
Salt
Alcohol
Renin
Diabetes
How is essential hypertension diagnosed?
Blood pressure readings on 3 different occasions >140/90mmHg
What is the treatment for essential hypertension?
Lifestyle changes
- *<55 years of with type 2 diabetes**
1. ACE inhibitor - Ramipril, Captopril
2. Add calcium channel blocker - Amplodipine, Verapamil
3. Add thiazide-like diuretic e.g. Indapamide - *>55 years or black patients of African/Carribean descent**
1. Calcium channel blocker
2. Add ACE inhibitor
3. Add thiazide-like diuretic

What week is hypertension in pregnancy diagnosed?
20 weeks
What if an ACE inhibitor is not tolerated e.g. because of a cough
Offer angiotensin 2 receptor blocker - Candesartan, Azilsartan



















