Obstructive Sleep Apnea Flashcards

(47 cards)

1
Q

obstructive sleep apnea: definition + repetitive collapse of _________?

A

Definition:
- Recurrent episodes of partial or complete airway obstruction during sleep
- Caused by repetitive collapse of PHARYNX
- Results in recurrent awakenings/arousal = ↓ Quality of sleep

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2
Q

epidemiology of sleep apnea

A

Commonly:
- Sleep apnea does not pose any symptoms even with >5 events per hour

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3
Q

sleep apnea: risk factors

A

-Obesity**
-Older age
-ETOH or sedative drugs
-Nasal obstruction
-Smoking
-Craniofacial and upper airway soft tissue abnormalities
—–

sleep apnea: FAT old guy that loves smoking and drinking; who has messed up nose that snores lots

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4
Q

hypopnea vs apnea

A

HYPOPNEA- REDUCTION in airflow
-10s event with breathing BUT
- ventilation during sleep is REDUCED
-respiratory effort: at least 50% from baseline

APNEA: complete CESSATION of airflow
-10s event with cessation of airflow
-Obstructive apnea: no airflow but with continued respiratory EFFORT
-Central apnea: no airflow and no respiratory effort

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5
Q

pathophysiology of sleep apnea.irway occlusion is limited to ________.

A

pathophysiology: Narrowing of upper airway during sleep!!!
- Airway occlusion is LIMITED TO INSPIRATION**

OSAHS pts have smaller upper airway size due to:
-fat deposition
- facial bone structures
-Genetics

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6
Q

Sleep apnea comorbidities

A

Strong association with and potential cause of many medical conditions:
- Hypertension
- Pulmonary HTN/cor pulmonare
- cardiovascular disease
- Stroke
- Diabetes
- Depression
- Sleepiness-related accidents

Lots of cormorbid ds and can result in pul hypertension or cor pulmoare

Sleep apnea needs to be identified and treated

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7
Q

sleep apnea symptoms

A

-Sleepiness and daytime somnolence: MC*
-Poor concentration*
-snoring*
-Bed partners report: snoring, apneas, restless sleep, or irritability*

-Fatigue
-Unrefreshing sleep
-Nocturnal choking
-Nocturia: pee at night
-Depression and decreased libido

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8
Q

signs of sleep apnea

A

-Macroglossia, enlarged tonsils, nasal obstruction
-HTN common
-“crowded” upper airway
-Obesity
-Large NECK circumference ( >17 inch [males]; >16 inch [females])*
-Craniofacial abnormalities: retrognathia

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9
Q

cardinal symptoms of sleep apnea apnea

A
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10
Q

epworth sleepiness scale

A

Used to define whether someone is abnormally sleepy
A ESS Score > 12 is suggestive of Sleep Apnea

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11
Q

Sleep apnea: labs

A

-Secondary polycythemia: from hypoxia
-Some may have hypercapnea, lowP02
-Proteinuria
-Hypothyroidism

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12
Q

Sleep apnea: ekg

A

-Nocturnal cardiac arrhythmia
-Sinus bradycardia, sinus arrest or AV block
-SVT, A fib and VT may occur once airflow is re-established

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13
Q

dx of sleep apnea

A

Golden Standard = Polysomnography (AKA Sleep Study)
-There is night-to-night variability so first night negative test does NOT r/o sleep apnea

Apnea Hypopnea Index:
- 15 events/hr: asymptomatic
- 5 events/hr: symptomatic or with comorbidities

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14
Q

definitive dx: apnea hypopnea index (AHI) criteria

A

Apnea Hypopnea Index diagnosis criteria:
- 15 events /hr of sleep: asymptomatic
- 5 events/hr: symptomatic

SYMPTOMS (one or more)
-Excessive daytime sleepiness
-Choking or gasping from sleep
-Recurrent awakenings from sleep
-Feeling unrefreshed after sleep
-Daytime fatigue
-Poor concentration

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15
Q

severity of sleep apnea: AHI index

A

Mild:
- 5-14 events per hour of sleep
Moderate:
- 15-30 events per hour of sleep
Severe:
- >30 events per hour of sleep

just know vaguely

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16
Q

tx of sleep apnea

A
  • Weight loss **
  • AVOID EtOH & Hypnotics **
  • CPAP: Continuous Positive Airway Pressure
  • Oral Appliances: Recommended for more severe cases
  • Surgical Procedures: Indicated if only there is some surgical intervention (enlarged tonsils, etc)
  • Hypoglossal nerve stimulation (INSPIRE)
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17
Q

new sleep apnea tx- inspire

A

-Implantable upper airway stimulation device functions like a pacemaker
-sends regular electrical impulses to the hypoglossal nerve to maintain upper airway patency

Components:
- programmable neuro-stimulator placed in chest
- pressure sensing lead: detects patient’s breathing
- stimulator lead: stimulates hypoglossal nerve

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18
Q

obesity hypoventilation syndrome

A

Definition:
- presence of awake alveolar hypoventilation (PaCO2 ≥45 mmHg)
-pt is OBESE (BMI ≥30 kg/m2),
-Hypoventilation cannot be attributed to other conditions

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19
Q

obesity hypoventilation syndrome: clinical features of cns, respiratory, cardiovascular

A

CNS:
- decreased CENTRAL respiratory drive

Respiratory:
- restrictive chest physiology
- pulmonary HTN
- hypoxemia/hypercapnia
-severe airway obstruction
- obstructive sleep apnea

Cardiovascular:
- CAD
- CHF

20
Q

obesity hypoventilation syndrome: dx

A

DX:
- Chronic respiratory acidosis (PaCO2 ≥45 mmHg) with compensatory metabolic alkalosis
-must exclude other diseases that can cause or contribute to chronic alveolar hypoventilation or hypercapnia.

Work up:
-assess for common complications
-ex: pulmonary hypertension + cardiovascular disorders

21
Q

obesity hypoventilation syndrome: tx

A

Tx: CPAP therapy
- improves gas exchange, lung volumes, and sleep-disordered breathing
- reduces mortality

Crap im obese

22
Q

acute respiratory distress syndrome (ARDS)

A

Definition:
-Acute hypoxemic respiratory failure WITHOUT HF
- acute event caused by systemic or pulmonary insult (infection, trauma, sepsis)
-will have NORMAL pulmonary capillary wedge pressure (≤ 18 mm Hg) -> normal heart; no HF
-Bilateral, widespread pulmonary infiltrates on x-ray (“WHITE OUT”)

23
Q

ARDS PaO2/FIO2 ratio

A

-pt will have PaO2/FIO2 ratio <300: Arterial oxygen over concentration of oxygen being inhaled

so for ex, if PT has Pa02 of 60 while receiving 80% o2= 60/.8= 75.

24
Q

severity of ARDS

A

Based on PaO2/FIO2 ratio :
-Mild: 200-300 mm Hg
-Moderate: 100-200 mm Hg
-Severe: less than 100 mm Hg

PaO2/FIO2 ratio: tells you degree of hypoxemia
PaO2 = arterial O2
FIO2 = fraction of inspired oxygen (expressed as decimal)

25
common risk factors for ARDS
-Sepsis (1/3 of pts)** -Severe multiple trauma ** -large Aspiration of gastric contents ** ------- -Shock -Infection -Lung contusion -Nonthoracic trauma -Toxic inhalation -Near-drowning -Multiple blood transfusions -Drugs all of these are the "systemic or pulmonary insults"
26
ARDS pathophysiology
1) insult causes release of pro-inflammatory cytokines -> promotes tissue destruction + inflammation Lung Inflammation causes: - ↑ Vascular Permeability = Interstitial & Alveolar Edema + Bilateral Diffuse Infiltrates - ↓ Alveolar Surfactants = Alveolar Collapse + Hypoxemia
27
ARDS symptoms and signs
RAPID onset of really bad dyspnea: -FROTHY RED OR PINK SPUTUM** -Diffuse crackles everywhere -Marked hypoxemia refractory to tx with supplemental oxygen *** - Many pts demonstrate multiple organ failure ——- -Labored breathing -Tachypnea -accessory inspiratory muscles
28
ADRS: what must you r/o?
HEART FAILURE - diffuse crackles -multiple organ failure - dyspnea -cadiogenic pulmonary edema
29
ARDS Chest radiography
Findings: "white out" - May be normal at first -BILATERAL infiltrates usually peripheral - Air BRONCHOGRAMS * (80%) -> alveolar inflitrates Normal: -Heart size normal - spares costophrenic angles: no pleural effusions
30
ARDS tx
-Treatment of underlying precipitating or secondary conditions (ex: sepsis) -Tracheal intubation -PEEP: Positive End Expiratory Pressure = Keeps alveoli open -Supplemental O2 - Fluid Management ------- basically: give PEEP and O2 but not too much for O2 toxicity and give fluids but not too much to cause HF
31
ARDS: O2 + PEEP
PEEP: Positive End Expiratory Pressure = Keeps alveoli open - Ideally keep PEEP ↓ and Supplemental O2 ↓ as possible PEEP goal: - PaO2 > 55 mmHg or SaO2 > 88% O2 goal: - Recommended FIO2 < 60% with <40% the safest - avoid oxygen toxicity ------------ Fraction of inspired oxygen (FIO2): percentage of O2 in the gas mixture that is inhaled Oxygen saturation (SaO2): proportion of Hb that are saturation
32
ARDS: fluid management
- want to maintain pulmonary capillary wedge pressure at the LOWEST level compatible with adequate cardiac output - don't want to fluid overload (HF)
33
ARDS prognosis
-30-40% Mortality Rate -90% Mortality with Sepsis -Median Survival Time ~ 2 weeks - If pts survive: will have SIGNIFICANT respiratory impairments
34
pulmonary aspiration syndromes definition and causes
Definition: Aspiration of material Causes: Impaired deglutition - Secondary to Altered Consciousness - Secondary to Esophageal Dysfunction
35
Different types of aspirations
-Aspiration of Inert Material -Aspiration of Toxic Material -"Café Coronary" -Retention of Aspirated FB -Chronic Aspiration of Gastric Contents -Acute Aspiration of Gastric contents
36
aspiration of inert material
Inert Material: non-hazardous = No serious sequelae - Aspiration of particular matter or large volumes of fluid - May present with asphyxia if amount aspirated is MASSIVE -- ex: waterboarding
37
aspiration of toxic material - what does it cause, sx, tx
May cause hydrocarbon pneumonitis**: aspiration of ingested petroleum distillates: -Gasoline, kerosene, furniture polish - occurs in suicide attempt or child accidentally ingesting toxic material -Lung injury: mainly from vomiting and aspiration Symptoms: - vomiting, coughing - respiratory distress - cyanosis - fever Tx: supportive care "toxicpeople go low and hide in the middle, they are initially normal and then get worse at night"
38
aspiration of toxic material - chest xray + tx
CXR: initially be normal -> significantly progress over the next 12 hours. Patchy airspace consolidation particularly in: - LOWER lobes - medial basal segments Tx: supportive "toxic ppl: - go low and hide in the medial base - initially normal and can get worse at night (12 h)"
39
lipoid pneumonia
Chronic syndrome due to REPEATED aspiration of oily materials - Mineral oil, cod liver oil, and oily nose drops -Can cause pneumonia and fibrosis - MC: Elderly patients with impaired swallowing -Cough is present Dx: lipid laden alveolar macrophages - sputum sample or bronchial washings with + lipid-laden alveolar macrophages "Lipoid = Oily Fat People" - can cause Fibrosis and Pneumonia - chronic ingestion of oily substances - Oily: Old ppl with impaired swallowing -> cough a lot
40
Cafe coronary + risk factors
Definition: ACUTE obstruction of the upper airway by FOOD Associated with: -Difficulty swallowing -Old age -Dental problems that impair chewing -Use of alcohol and sedative drugs Tx: Heimlich procedure
41
Retention of Aspirated Foreign Body: what does it cause
May be acute, chronic, or asymptomatic: these are what it can cause: "foreign Body -> Being HAPA is a foreign body" - Bronchiectasis - Hyperinflation - Abscess (lung) - Pneumonia (recurrent) - Atelectasis" ---- -recurrent pneumonia -Bronchiectasis -Lung abscess -Atelectasis -Postobstructive hyperinflation
42
Retention of Aspirated Foreign Body imaging
CXR: - usually suggests the site of the foreign body Golden Standard = Bronchoscopy - Establishes Dx & Removal of FB "foreign BOdy = BrONchoscopy -> BB"
43
chronic aspiration of gastric contents
Result from primary disorder of larynx or esophagus: -Untreated asthma -esophageal stricture -achalasia -scleroderma -chronic reflux it can cause: - Bronchial asthma - pulmonary fibrosis - bronchiectasis
44
chronic aspiration of gastric contents: dx and tx
Dx: "swallowing disorders" - EGD - barium swallow Tx: - EGD Dilate - PPI - H2 Blocker - Metoclopramide: increase gastric emptying
45
acute aspiration of gastric contents def+ what can it cause?
Catastrophic event!! -> response depends on how much was aspirated -more acidic + more quantity = WORSE chemical pneumonitis -Aspiration of pure gastric acid (pH < 2.5) -> ARDS What can it cause: "HEbP = HELP!!" -Hemorrhage: bleeding in lungs -Extensive desquamation of the bronchial epithelium -Bronchiolitis -Pulmonary edema
46
acute aspiration of gastric contents: chest xray
-Patchy alveolar infiltrates in dependent lung zones -Appear within few hours and progresses - If particular food matter = Obstruction may be observed
47
acute aspiration of gastric contents: treatment
ABCs: -Maintain the airway -Supplemental oxygen - mechanical ventilation if ARDS Supportive: -Fluids for hypotension -Treatment of superinfection -> prevent secondary infection "ACUTE= ABCs - airway: maintain airway - Breathing: ventilate if respiratory failure (ARDS); O2 - Circulation: fluids for hypotension + treat superinfections"