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Pharm > Ocular ADRs > Flashcards

Ocular ADRs Flashcards

1
Q

Amiodarone (Cordarone)

A

Anti-arrhythmic - vortex keratopathy

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2
Q

digoxin, digitoxin

A

Anti-arrhythmic, CHF - color changes = toxicity

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3
Q

tamsulosin (Flomax)

A

benign prostatic hypertrophy, HTN - floppy iris syndrome. Watch out in cataract surgery

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4
Q

sildenafil (Viagra)

A

Colour perception (transient), NAION.

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5
Q

hydroxychloroquine (Plaquenil)

A

Whorl opacity in cornea, bullous maculopathy (do 10-2)

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6
Q

quinine

A

Leg cramps, malaria, suicide - VA decrease, flickering vision, sudden complete loss of vision and fixed pupils, VF loss, night vision problems

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7
Q

Gold salts

A

RA - stromal deposits

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8
Q

indomethacin (Indocin)

A

NSAID - RPE changes perifoveally, CV loss, VA and VF defects

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9
Q

clomiphene (Clomid)

A

Infertility - ocular migraine Sxs

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10
Q

COX2 inhib - ‘coxibs’…Vioxx, Celebrex, Bextra, Prexige

A

Blurred vision, conjunctivitis

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11
Q

Retinoids (isotretinoin/Accutane, Vit A, vesanoid, Soriatane, Tegison)

A

Dry eye, corneal opacities, ICH, CV loss temporary

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12
Q

topiramate (Topomax)

A

Epilepsy, migraines, weight loss - bilateral acute angle closure glaucoma secondary to AC shallowing secondary to suprachoroidal effusion and acute myopia.Treatment = hyperosmotics, cycloplegics, IOP lowering agents

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13
Q

vigabatrin (Sabril)

A

Anticonvulsant - VF constriction (irreversible) bilateral w/temporal and macular sparing. CV loss. Do baseline VF and CV…FU q6mnths.

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14
Q

pamidronate disodium (Aredia) and other bisphosphates (the ‘dronates’)

A

Decreased calcium absorption in malignancy, Paget Dx, bone metastasis) - blurred vision, pain, photophobis, uveitis, lid edema, RETROBULBAR NEURITIS, diplopia, visual hallucinations

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15
Q

cetirizine (Zrtec/Reactin)

A

oculogyric crisis/rolling back eyes. Stop taking it.

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16
Q

tamoxifen (Nolvadex)

A

Chemo for primary metastatic breast cancer. Crystalline retinopathy, PSC, whorl keratopathy. May want to do amsler and CV

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17
Q

carmustine (BiCNU)

A

IV chemo agent. Vision loss, retinal complications include infarction, phlebitis, BRAO, NFL hem, mac edema)

18
Q

ethambutol (Myambutol)

A

Anti-TB - optic neuropathy (usually retrobulbar, bilateral w/ dec VA, CV, or central scotoma or bilateral temp defect)

19
Q

rifabutin

A

TB treatment - UVEITIS, optic neuropathy, endothelial deposits, pink tears

20
Q

methotrexate

A

RA or inflammation - optic neuritis

21
Q

isoniazid

A

anti-TB - optic neuritis

22
Q

tetracyclines (doxy, mino)

A

blue discoloration of sclera with minocycline, conjunctival deposits with tetracycline. ICH!!!! Tell them to come in if they experience blurred vision, HAs, diplopia

23
Q

chloramphenicol

A

Antibacterial - optic neuritis

24
Q

atvaquone (Mepron)

A

Antiparasitic - whorl keratopathy

25
Q

sulfonamides

A

antibacterial - allergic rxn, SJ synd and possible uveitis. Japanese and Korean ppl more likely to get SJ synd. Oc surface Dx…

26
Q

CAIs - acetazolamide (Diamox), dichlorphenamde (Daranide), methazolamide (Neptazane, Glauctabs)

A

Anticonvulsant, ICH - SJ synd, myopia, aplastic anemia.

27
Q

cidofovir (Vistide)

A

Treatment of cytomegalovirus in AIDS Pxs - uveitis (immune recovery), macular edema, macular gliosis.

28
Q

Oral contraceptives, Hormone replacement therapy

A

Dryness.

29
Q

chlorpromazine (Thorazine)

A

antipsychotic - corneal pigment, anterior SC. Advise UV protection

30
Q

thiordazine (Mellaril)

A

anti-psychotic - pigmentary retinopathy than can lead to dec VA, CV, dark adaptation

31
Q

All phenothiazines

A

Antipsychotic - trouble focusing, mydriatic. Check angles.

32
Q

lithium

A

Jerk nystagmus, blurred vision

33
Q

talc

A

Emboli. May also have macular edema, blood problems. Glaucoma risk

34
Q

Weed

A

25% IOP lowering for 3-4 hrs

35
Q

canthaxanine

A

(Herbal) Crystalline retinopathy

36
Q

chamomile

A

allergic conjunctivitis

37
Q

Datura

A

(Herbal) Mydriasis

38
Q

Echinacea

A

conjunctivitis

39
Q

ginko

A

Hyphema, retinal hem

40
Q

licorice

A

migraine Sxs

41
Q

niacin

A

Cystoid macular edema, dry eye

42
Q

Vit A

A

ICH

Pharm (2 decks)

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