Ocular immunity

Question 1

PLA2 (Phospholipase A2) is blocked by what? Most powerful way of anti-inflammation.

Answer 1

Steroid, cuts the head off the snake

steroids also act at multiple levels at the body, affecting gene expression as well

Question 2

What all relies on Arachidonic cascade?

Answer 2

Fever, inflammation, platelet activation

Question 3

What targets the COX pathway?

Answer 3

NSAIDS like aspirin target Cyclooxygenase
-Aspirin irreversibly acetylates platelets
(other NSAIDS are reversible)

Question 4

Normally a person will make __________ antibodies to an antigen. Multiple B cells and epitopes.

Answer 4

polyclonal (many different antibodies to an antigen

Question 5

These are cloned from one B cell for a single epitope and single antigen. A cancer/ Hybridoma

Answer 5

Monoclonal antibodies

Question 6

What type of monoclonal antibody is 1/3 mouse and 2/3 human?

Answer 6

Chimeric monoclonal antibody

Question 7

What type of monoclonal antibodies is 5% mouse and 95% human?

Answer 7

Humanized monoclonal antibody

Question 8

Monoclonal antibody will always end with \_\_\_\_. 
Suffix sources: umab:
              ximab:
     zumab:
ci(r)= 
li(m)= 
tu(m)=

Answer 8

Mab

umab: human
ximab= chimera
zumab= humanized
ci(r)= circulatory
li(m)= immune system
tu(m)= tumor

Question 9

Adalimumab (humira)

Answer 9

Targets immune system of human

Question 10

Infliximab (remicade)

Answer 10

Immune Chimera
TNf-alpha inhibitor
TNF alpha = prototypical inflammatory markers

Question 11

TNF-alpha

Answer 11

Macdaddy of Pro inflammatory cytokines

Question 12

Il-6

Answer 12

Does liver pro inflammatory markers

Question 13

Suffix sources: umab:

Answer 13

umab: human

Question 14

ximab:

Answer 14

ximab= chimera (66% human)

Question 15

zumab:

Answer 15

zumab= humanized (95% human)

Question 16

Ci(r)=

Answer 16

circulatory

Question 17

li(m)=

Answer 17

immune

Question 18

tu(m)=

Answer 18

tumor

Question 19

Bevacizumab (Avastin)

Answer 19

circulatory human

Angiogenesis inhibitor

Question 20

Adalimumab

Answer 20

immune human (100% human)

Question 21

Rituximab

Answer 21

Tumor chimera

Question 22

Trastuzumab

Answer 22

tumor humanized

Question 23

Infliximab

Answer 23

immune chimera