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Systemic Pathology > Ocular pathology 2 > Flashcards

Ocular pathology 2 Flashcards

1
Q

What is the uvea?

A

vascular structure of the eye

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2
Q

Components of the uvea

A
  • iris
  • ciliary body
  • choroid
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3
Q

What is anterior uveitis?

A

inflammation of the iris &/ or ciliary body

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4
Q

What is posterior uveitis?

A

inflammation of the choroid

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5
Q

What are some effect that uveitis can cause to the globe?

A
  • Corneal edema
  • keratic precipitation
  • synechiae
  • cataract
  • retinal detachment
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6
Q

How does Uveitis cause corneal edema?

A

cytokine-induced permeability of the vasculature in the peripheral limbic vessels

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7
Q

How does uveitis cause keratic precipitation in the cornea?

A

aggregates of cells & fibrin on the posterior surface of the cornea

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8
Q

How does uveitis cause cataracts at lens?

A

alteration of flow & composition of the aqueous humor

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9
Q

What does uveitis usually cause the formation of?

A

pre-iridal fibrovascular membrane (granulation tissue

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10
Q

When are angiogenic factors released in uvea?

A
  • chronic uveitis
  • hypoxemia (retinal detachment)
  • neoplasia
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11
Q

What is anterior synechia?

A

fibrin within the anterior chamber coating the iris, leading to adherence of the iris to cornea

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12
Q

What is posterior synechia?

A

fibrin within th anterior chamber coating the iris, leading to adherence of the iris to the lens

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13
Q

How does iris bombe occur?

A
  • complete circumferential posterior synechia
  • cause disruption of flow in the aqueous from posterior to anterior chamber (pupillary block)
  • increase in pressure
  • causes anterior bowing of the iris
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14
Q

What is the most common cause of glaucoma, cataracts, & blindness in horses?

A

equine recurrent uveitis

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15
Q

Characteristics of equine recurrent uveitis

A
  • syndrome
  • waxing & waning uveitis
  • starts off unilateral and ends up being bilateral
  • presentation: corneal edema, aqueous flare, vitreal protein
  • lymphocytes in ciliary epithelium & iris
  • amyloid-like deposition on ciliary epithelium
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16
Q

What does chronic equine recurrent uveitis present as?

A

-cataract
- retinal detachment
- lens luxation
- glaucoma
-blindness

17
Q

Pathogenesis of equine recurrent uveitis

A
  • unknown
  • considered multifactoral: autoimmune & infectious agent (altering normal immunologically privileged state of the eye
18
Q

What is the most common uveitis in cats?

A

idiopathic lymphoplasmacytic uveitis

19
Q

Presentation of Feline lymphoplasmacytic uveitis?

A
  • corneal edema
  • vascularization
  • keratic precipitation
  • secondary glaucoma is common
  • can be unilateral or bilateral

Systemic Pathology (2 decks)

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