Ocular Side Effects

Question 1

Drugs that cause Whorl Keratopathy

Answer 1

chloroquine
hydroxychloroquine
amiodarone
tamoxifen
indomethacin

Question 2

Drugs that cause SPK

Answer 2

isotretinoin (Accutane)

aminoglycosides- tobragent 30

Question 3

Drugs that cause pigmentation on endothelium/ Descemet’s

Answer 3

chlorpromazine
thioridazine
promethazine

Question 4

Amiodarone SE

Answer 4

whorl keratopathy
ant subcapsular lens deposits
NAION

Question 5

Drugs that cause anterior subcapsular toxicity

May Trigger Anterior Cataracts

Answer 5

Miotics
Thioridazine
Amiodarone
Chlopromazine

Question 6

Drugs that cause PSC

Answer 6

steroids

Question 7

Isotretinoin (Accutane) SE

Answer 7

blepharoconjunctivitis
dryness
lid edema
color vision loss
nyctalopia

Question 8

Blood Thinners (Warfarin, NSAIDs) SE

Answer 8

subconj hemes

Question 9

Sulfonamide SE

Answer 9

Stevens Johnson Syndrome

Question 10

Tetracyclines SE

Answer 10

pigmented cyst on conj (minocycline)

Question 11

Sildenafil (Viagra) SE

Answer 11

subconj heme
conjunctival hyperemia
NAION

Question 12

Prostaglandin SE

Answer 12

conjunctival hyperemia

increased lash growth

Question 13

Tamiflu SE

Answer 13

conjunctivitis

Question 14

Drugs that decrease tear secretion

Answer 14

anticholinergics- atropine, scopolamine
antidepressants- TCAs, amitriptyline, imipramine
antihistamines- -phen-
Isotretinoin (Accutane)
B blockers- olol
Hormone- contraceptives, HRT
ADHD- Ritalin, dextroamphetamine (Dexadrine)
Diuretics- hydrochlorothiazide, thiazide, furosemide, triamterene

Question 15

Drugs that cause mydriasis/ angle closure

Answer 15

anticholinergics- atropine, scopolamine
antihistamines- -phen-
SSRIs- Prozac, Lexapro
SNRIs- Cymbalta, Effexor
TCAs- amitriptaline, imipramine
Phenothiazines- chlorpromazine, thioridazine
Benzos- diazepam (Valium)
Dopamine agonists- Ritalin, Dextroamphetamine (Dexedrine), amantadine (Symmetrol), bromocriptine

Question 16

Drugs that cause miosis

Answer 16

opiates- morphine, heroine, codeine
Acetylcholinesterase inhibitors
Donepezil

Question 17

Drugs that cause Nystagmus

Answer 17

phenytoin
phenobarbital
NSAIDs

Question 18

Drugs that cause diplopia

Answer 18

antidepressants, antianxiety, phenytoin

Question 19

Drugs that impair saccades

Answer 19

alcohol

Question 20

Drugs that cause oculogyric crisis

Answer 20

phenothiazine

cetirizine (Zyrtec)

Question 21

Drugs that cause Floppy Eyelid Syndrome

Answer 21

a1 blocker- Flomax, terazosin, prazosin

Question 22

Drugs that cause blue sclera

Answer 22

steroids

minocycline

Question 23

Drugs that cause secondary angle closure

Answer 23

Topamax via choroidal swelling

Question 24

Digoxin SE

Answer 24

retrobulbar optic neuritis
B/Y defects
snowy vision

Question 25

Ethambutol SE

Answer 25

bilateral retrobulbar optic neuritis

Question 26

Oral Contraceptives SE

Answer 26

``` optic neuritis papilledema pseudotumor cerebri CRVO dry eye ```

Question 27

Drugs causing bulls eye maculopathy

Answer 27

chloroquine, hydroxychloroquine

Question 28

Tamoxifen SE

Answer 28

crystalline deposits around macula | macular edema

Question 29

Drugs that cause pigmentary retinopathy

Answer 29

thioridazine chlorpromazine promethazine

Question 30

Indomethacin SE

Answer 30

retinal hemorrhage | pigmentary changes in macula

Question 31

Drugs that cause retinal hemorrhage

Answer 31

NSAID

Question 32

Zidovudine (Retrovir) SE

Answer 32

macular edema

Question 33

Drugs that cause Intracranial Hypertension/ Pseudotumor Cerebri

Answer 33

``` contraceptives accutane tetracycline synthroid steroids ```

Question 34

Drugs that increase IOP

Answer 34

atropine, scopolamine antihistamines- phen TCA- amitriptyline, imipramine Antipsychotics- phenothiazine, chlorpromazine, thioridazine SABA- albuterol, levalbuterol, terbutaline Pseudoephedrine steroids