Oedema + Vascular disease

Question 1

Why are diuretics normally given in the morning?

Answer 1

to avoid night-time diuresis

Question 2

What is the MHRA warning for metolazone?

Answer 2

cannot switch between 5mg tablets
- different bioavailabilities and dosing preparations

Question 3

What are the side effects of thiazide like diuretics?

Answer 3

HYPERuricaemia
HYPERglycaemia
electrolyte imbalance: calcium, sodium, potassium, chloride

Question 4

When are eplerenone and spironolactone CI?

Answer 4

BOTH: hyperkalaemia

spironolactone: anuria, Addison’s disease

Question 5

What is the treatment for peripheral vascular disease?

Answer 5

nifedipine
prazosin
naftidrofuryl oxalate
cilostazol
pentoxifylline

Question 6

What is the QRISK score?

Answer 6

assesses 10 year CVD risk
- not suitable for high risk patients: T1DM, CVD, CKD

> 10%: start atorvastatin 20mg OD (low intensity statin)

Question 7

What is the NHS Health Check programme?

Answer 7

for ages 40-74 yrs with NO previous diagnoses
- every 5 yrs