Office/Lifestyle management Flashcards
(57 cards)
When do you prescribe statins?
- clinical CVD (prior MI, CVA, uncontrolled HTN)
- LDL>190
- DM age 40-75 with LDL 70-190 and w/o clinical CVD
- LDL 70-190 and 10 yr CVD risk >7.5%
- statin therapy is mod or high intensity and based on what % the LDL is lowered. Mod is decr LDL 30-50%, high is decr LDL >50%.
What is lipid panel interpretation?
Total cholesterol:
- goal <200, borderline 200-240, high risk >240
LDL:
- goal <100, borderline 100-160, high risk <160
HDL:
- goal >60, borderline 40-60, high risk <40
Triglycerides:
- goal <150, borderline 150-885, high risk <885
CVD is leading cause of death for women!
What is the definition of obesity?
BMI <30
Class 1: BMI 30-35
Class 2: BMI 35-40
Class 3: BMI >40
What are health risks of obesity?
Cardiovascular: CAD, CVA, HTN, abnormal lipids
Reproductive: infertility, PCOS, AUB, incr preg risk
Malignancy: breast, endometrial, colon cancer
Endocrine: DM, metabolic syndrome
GI: GERD, gallstones
Pulmonary: OSA
Hematologic: vTE
Management goals: 5-10% body weight in 6 mo. see pt 1/month.
Medical tx if BMI >30 or if >27 and other risk (DM/HTN)
Bariatric surgery: wait 12-24mo after surgery to conceive
Pre-conception screen for ferritin, iron, CBC, thiamine, folate, calcium and Vitamin D.
Surgery in obese pts: antibiotics 2g cefazolin if weigh >80kg and 3g cefazolin if >120kg. post-op hypoxemia common, use IS or CPAP. use opioids conservatively.
What are recommendations for Hep B/C screening in pregnancy?
- screen for HbsAg and hep C Ab in each pregnancy regardless of vaccination status
- triple panel screening (HBsAg, anti-HBS, total anti-HBc) if no documented neg result after age 18
- if Hep C Ab pos, get RNA PCR to confirm ddx. if PCR neg, do another antibody test to confirm its not false positive.
screen for hep C infection/treatment ideally pre-conception. tx w/ 12-24w ribavirin and wait 6 months to conceive.
- preconception counseling if hep B/C pos: affects maternal and fetus/neonate. Hep C has incr risk fGR, PTB, ICP.
What is management of hep B/C infection?
Hep B
- test for total. anti-hBc, IgM anti-HBc, anti-HBs and HBV DNA to determine viral load, chronic vs acute infix.
- use antivirals in 3rd tri if VL>200K. tenofovir is 1st line (300mg qd)
- low risk vertical transmission w/ amnio
- insufficient evidence to avoid FSE, episiotomy, operative VD.
- neonates need HBIG and HBV within 12hrs birth.
- breastfeeding encouraged and tenofovir NOT contraindication.
hep C
- vertical transmission w/ amnio/CVS is low. no treatment options.
- breastfeeding is okay
- connect w/ hepatitis care so can start antivirals postpartum AFTER breastfeeding.
What are recs for hep A vaccination in pregnancy?
- give hep B if haven’t been vaccinated
Hep A if high-risk:
- international travelers, illegal drug use, homeless
- high risk for severe disease: chronic liver disease, HIV.
Info: small RNA virus. fecal/oral transmission. transmitted from contained food/water.
What is hepatitis B?
small DNA virus.
-transmitted sexually and parenteral contact. 1% mortality
- HBcAg present in hepatocytes only (doesn’t circulate).
- 10-15% develop chronic infection. +HBsAg.
- chronic carrier: +HBsAg, no Hbs IgG
- perinatal transmission largest cause of chronic infection worldwide. without antiviral tx or neonatal prophylaxis, transmission as high as 90%
What is hepatitis C?
Small RNA virus. 75% of infections asymptomatic
- 20% of chronic HC infections lead to cirrhosis.
- co-infection w/ HIV accelerates progression/severity of hepatic injury.
- transmission: primarily IV drugs but also sexually.
- most common blood borne infection in USA.
What is hepatitis D and E?
Hep D:
- incomplete viral particle. only causes disease if hep B present. high risk cirrhosis and portal HTN. 25% mortality.
Hep E:
- incomplete RNA virus. transmitted fecal/oral. 30% mortality.
What is interpretation of screening results for HBV?
acute infection: +HBsAg, + total anti-HBc, + IgM anti-HBC
chronic infection: +HBsAg and + total anti-HBc
immune: +anti-HBs
Total anti-HBc is both IgM and IgG Ab
- if Anti-HBs concentration >10mIU/ml after vax series completed, patient is immune
chronic hep B possibly associated w/ LBW.
What are the recommendations for HRT?
used for relief of disturbing vasomotor sx for lowest effective dose and for shortest time.
- use if < 10 yrs from menopause and < 60 yo.
various regimens: unopposed estrogen if s/p hyst or combined estrogen/progestin if intact uterus to prevent endometrial hyperplasia.
- oral medroxyprogesterone (provera): incr VTE risks
- oral micronized progesterone: vasodilator, no effect on VTE
- oral estrogen: prothrombotic, incr VTE. lose-dose options below
– 0.5mg oral estradiol. - 0.025mg/d estradiol patch
– 0.3mg oral CEE (conguated equine/premarin) - transdermal estrogen: little/no VTE risk.
What are the risks of combined HRT?
What are contraindications?
- MI
- CVA
- VTE
- breast cancer
- gallbladder disease
- dementia
- SE: mastalgia, bloating, HA
CONTRAINDICATIONS:
- pregnancy, breast cancer, estrogen sensitive tumor. undiagnosed vaginal bleeding, hx dVT/thrombophilia, severe liver disease. CAD, CVA.
- HTN, smoking, migraines w/ aura are NOT contraindications but transdermal estrogen preferred.
What are the benefits of combined HRT?
reduced risk of colorectal cancer, osteoporotic fractures, vasomotor/sleep sx.
- symptoms should improve in 2-4 weeks (resolve in 1-2 months). IF not, increase dose.
What were findings from WHI study?
- incr risk VTE, CVA and breast cancer for HT
- no cardio protection
- risk VTE greater in E/P than E alone.
- CVA risk highest in women >65
HRT, specifically ERT does give significant CAD protection when initiated at the onset of menopause (aged 50-59). Based upon the WHI study, if there has been a hiatus of > 10 years, then there is significant risk of AMI and CVA if HRT is initiated then.
Causes of irregular menses and hot flushes: estrogen deficiency, hyperthyroid, malignancy, endocrine disorder.
What is the differential for chronic pelvic pain?
vague non-specific pain >6 months. Differential:
(most common=IBS, endometriosis, MSK, adhesions, painful bladder syndrome)
GYN:
- vagina: vestibulitis, vulvodynia
- cervix: cervicitis (chronic PID)
- uterus: degenerating fibroids, adenomyosis
- tubes: salpingits, hydrosalpinx, chronic PID
-ovaries: cysts, tumors
miscellaneous: endometriosis, adhesions
NON-GYN
- uro: painful bladder syndrome, bladder cancer, urethral diverticulum, chronic UTI
- GI: chronic constipation, diverticulosis, IBD, IBS, celiac
- MSK: trigger points, pelvic floor dysfunction, fibromyalgia, arthritis
- psych/neuro: depression/anxiety, somatization disorder, PTSD, nerve entrapment
- neuro: neuropathic pain.
What is the workup and treatment for chronic pelvic pain (CPP)?
PQRST: onset, precipitation, quality (focal or diffuse), radiation, severity, timing (aggravating and relieving factors). see if has pain currently!
Exam: palpate abdominal wall, pelvic floor muscles, low back, SI joints.
H&P (screen for depression/anxiety)
Gyn: bhcg, US, cervical culture, ?diag lsc as last resort
GI: abdominal imaging, sigmoidoscopy, colonoscopy
GU: UA/UCx, imaging, cysto
MSK: Xray pelvis/spine
pain clinic
2nd opinion
Tx: conservative! pelvic floor PT, CBT, neuropathic pain meds (SNRI, gabapentin, pregabalin), trigger point injections, acupuncture, yoga.
What is vulvodynia?
Vulvar pain >3 months and no identifiable cause.
localized: specific area of vulva (vestibule or clitorus) - ddx w/ Qtip test
Generalized: pain over entire vulva or multiple locations.
associated factors: provoked, spontaneous or mixed.
eval: r/o infix (pH, saline wet prep, fungal culture, gram stain, PCR), eval pelvic floor dysfunction.
Tx=multifactorial. vulvar care, topical meds (local anesthetic, estrogen cream), gabapentin, tricyclic antidepressants, steroid injections, dietary modifications, CBT/sexual counseling. vestibulectomy for refractory causes.
What is endometriosis?
Cause of CPP. 6-10% of reproductive age women, 40% of women w/ infertility, 70-80% of women w/ CPP. if hx 1st degree relative, 10X incr risk.
Etiology: retrograde menstruation, hematological or lymphatic spread
What is the treatment for endometriosis?
- OCPs, progestins, GnRH agonists/antagonists. If start w/ nSAIDs and OCPs/progestins, reassess in 3-4 mo. if no change, switch to other med.
GnRH agonist (Lupron/depo leuprolide). - transient stimulation of pituitary then suppression of pituitary/gonadal axis. give monthly.
- SE: menopausal sx, osteoporosis if long term
- not 1st line in adolescents.
- sx improvement in 1-2 mo, can use for 6 mo continuous. recommend add-back w/ progestins (norethindrone 5mg qd) or E+P
GnRH Antagonist (Elagolix, relagolix/Myfembree)
- effective immediately, induces hypoestrogenic state. ORAL form.
- SE: VMS, vaginal atrophy, bone loss)
- Elagolix dosing: 150mg daily x 2yr, reduces menstrual pain and pelvic pain, decreased dyspareunia w/ higher dose.
What is included in annual gyn visit?
screening, evaluation, counseling and immunizations.
- 1st visit age 13-15 (no pelvic exam)
- History (med, Surg, social, family, OB, gyn) - ask about diet/exercise, sexual function, IPV, depression/anxiety, incontinence, menopausal sx, new meds, substance abuse.
- Physical (breast exam, neck/abdomen, pelvic) - consider thyroid, skin, LN, chest.
- Screening: GC/CT, glucose annually at age 45, lipid q5yr at 21, DEXA at 65, HIV once, hep C once>18.
- Counseling: reducing health risks.
- exercise, breast awareness, diet (caffeine, cholesterol, calories), incr calcium (1200), vitamin D (600-800), fiber, folate.
- STD, contraception, hRT, driving, bone health, sexual health, vaginal sx, smoking/aocohol, drugs, pregnancy, future fertility.
What are screening strategies for alcohol use?
What are health risks of alcohol?
Screen for alcohol use
- unhealthy is >7 drinks/week or >3 drinks/day
TACE (preferable to CAGE bc addresses tolerance)
- Tolerance: how many drinks to get ‘high’
- Annoyed: do you get annoyed when asked about drinking
- Cut down: has anyone told you to cut down?
- Eye opener: do you have a drink shortly after awakening?
Health risks of alcohol:
- incr cardiac disease, hTN, fib, osteoporosis, dementia, pancreatitis, liver disease
- incr cancer of oral cavity, esophagus, breast, colorectal, liver, pancreas
- fetal alcohol syndrome.
- incr violence, accidents, suicides.
strategies to offer pt to help cut down
keeping record, setting goals, avoiding triggers (situations, people), planning ahead.
What is smoking cessation?
What are risks of smoking?
5As?
- Ask: about presence/degree of smoking
- Advise: to stop smoking
- Assess: pt willingness to stop smoking
- Assist: with counseling, support groups
- Arrange: follow-up
incr risk cancer (lung, bladder renal, colon, cervical)
incr risk CAD, VTE, osteoporosis, COPD, early menopause
Pregnancy: incr risk fGR, PPROM, LBW, previa, abruption, ectopic, perinatal mortality, SAB.
post-natal: SIDS, asthma/bronchitis, obesity, otitis media
After 15yrs quitting smoking, risk of CAD is that of non-smoker
What are screening tests for a 47 year old pt?
Pap smear every 5 years + concurrent HPV
Mammogram every 1-2 years
Colonoscopy if African American or family history
Labs:
TSH if symptomatic
Lipid panel every 5 years
Fasting glucose every 3 years
HIV (offer)
Hepatitis C (if born b/w 1945-1965 or if risk factors)
Depression
Intimate partner violence
Substance abuse (alcohol, tobacco, drug)