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El Grande USMLE Step 1 > OncoGene/Tumor Supressors > Flashcards

OncoGene/Tumor Supressors Flashcards

1
Q

BCR-Abl

A

CML, ALL. Tyrosine Kinase

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2
Q

Bcl-2

A

Follicular cell and undif lymphoma; Anti-apopotitc molecule

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3
Q

BRAF

A

Melanoma; Serine/threonin kinase

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4
Q

c-kit

A

GIST; cytokine receptor (for stem cell factor)

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5
Q

c-myc

A

Burkitt lymphoma t[8;14]; transcription factor

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6
Q

HER2/neu (c-erbB2)

A

Breast, ovarain and GI carcinomas; Tyrosine Kinase

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7
Q

L-myc

A

Lung tumors; transcription factor

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8
Q

N-myc

A

Neuroblastoma of adrneals; transcription factor

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9
Q

ras

A

colon cancer, lung cancer panc cancer; GTPase

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10
Q

ret

A

MEN2a/b, autodom; tyrosine kinase

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11
Q

APC

A

Colorectal cacner (FAP)

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12
Q

BRCA1/2

A

Breast and ovarian cancer; DNA repair protein

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13
Q

CPD4/SMAD4

A

Panc Cancer; DPC (DELETED IN PANC CANCER)

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14
Q

DCC

A

Colon Cancer (DCC=DELEETED IN COLON CNACER)

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15
Q

MEN1

A

MEN type 1

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16
Q

NF1

A

NF1: Chromo 17, RAS GTPase activating protein (neurfibromin)

17
Q

NF2

A

Chromo 22; Merlin (schwannomin) protein

18
Q

p16

A

Melanoma; CDK inhibitor 2a

19
Q

p53

A

Liframunei, most cancers; Transcription factor for p21 which blocks G1–>S phase (and interacts with RB!)

20
Q

PTEN

A

Breast cacner, porstate cancer, endometrial cacner

21
Q

Rb

A

Retinoblastoma AND osteosarcoma; inhibits E2F blocking G1–>S

22
Q

TSC1 TSC2

A

Harmartin, TSC2=Tuberin protein

23
Q

VHL

A

von hippel-lindua; inhibits hypoxia inducible factor 1a (thus vascular type cancers)

24
Q

WT1/2

A

Wilms Tumor (nephroblastoma)

25
Q

Alk phosph

A

Mets to bone, liver, paget disase of bone, seminoma (placental ALP)

26
Q

Alpha fetoprotein

A

HCC, Hepatoblaomsta, yolk sac (endodermal sinus) tumor, testuclar cancer, mixed germ cell tumor

27
Q

BhCG

A

Hydatidiform moles and choriocarciomas, testicular cancer

28
Q

CA-15-3/CA-27-29

A

Breast Cancer

29
Q

CA-19-9

A

Panc Adenocarcinoma

30
Q

CA-125

A

Ovarian Cancer

31
Q

Calcitonin

A

Meudllary THyroid carcioma

32
Q

CEA

A

CarcinoEmbryonic Antigen. Colorectal, panc. Also in some gastric, breast and medullarythyroid carniomas

33
Q

S-100

A

Neural Crest origin (melanomas, Neural tuomr,schwannoams, Langerhan cell hstiocytosis)

34
Q

TRAP

A

Hairy cell luekmia

El Grande USMLE Step 1 (5 decks)

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