OncoGene/Tumor Supressors

Question 1

BCR-Abl

Answer 1

CML, ALL. Tyrosine Kinase

Question 2

Bcl-2

Answer 2

Follicular cell and undif lymphoma; Anti-apopotitc molecule

Question 3

BRAF

Answer 3

Melanoma; Serine/threonin kinase

Question 4

c-kit

Answer 4

GIST; cytokine receptor (for stem cell factor)

Question 5

c-myc

Answer 5

Burkitt lymphoma t[8;14]; transcription factor

Question 6

HER2/neu (c-erbB2)

Answer 6

Breast, ovarain and GI carcinomas; Tyrosine Kinase

Question 7

L-myc

Answer 7

Lung tumors; transcription factor

Question 8

N-myc

Answer 8

Neuroblastoma of adrneals; transcription factor

Question 9

ras

Answer 9

colon cancer, lung cancer panc cancer; GTPase

Question 10

ret

Answer 10

MEN2a/b, autodom; tyrosine kinase

Question 11

APC

Answer 11

Colorectal cacner (FAP)

Question 12

BRCA1/2

Answer 12

Breast and ovarian cancer; DNA repair protein

Question 13

CPD4/SMAD4

Answer 13

Panc Cancer; DPC (DELETED IN PANC CANCER)

Question 14

DCC

Answer 14

Colon Cancer (DCC=DELEETED IN COLON CNACER)

Question 15

MEN1

Answer 15

MEN type 1

Question 16

NF1

Answer 16

NF1: Chromo 17, RAS GTPase activating protein (neurfibromin)

Question 17

NF2

Answer 17

Chromo 22; Merlin (schwannomin) protein

Question 18

p16

Answer 18

Melanoma; CDK inhibitor 2a

Question 19

p53

Answer 19

Liframunei, most cancers; Transcription factor for p21 which blocks G1–>S phase (and interacts with RB!)

Question 20

PTEN

Answer 20

Breast cacner, porstate cancer, endometrial cacner

Question 21

Rb

Answer 21

Retinoblastoma AND osteosarcoma; inhibits E2F blocking G1–>S

Question 22

TSC1 TSC2

Answer 22

Harmartin, TSC2=Tuberin protein

Question 23

VHL

Answer 23

von hippel-lindua; inhibits hypoxia inducible factor 1a (thus vascular type cancers)

Question 24

WT1/2

Answer 24

Wilms Tumor (nephroblastoma)

Question 25

Alk phosph

Answer 25

Mets to bone, liver, paget disase of bone, seminoma (placental ALP)

Question 26

Alpha fetoprotein

Answer 26

HCC, Hepatoblaomsta, yolk sac (endodermal sinus) tumor, testuclar cancer, mixed germ cell tumor

Question 27

BhCG

Answer 27

Hydatidiform moles and choriocarciomas, testicular cancer

Question 28

CA-15-3/CA-27-29

Answer 28

Breast Cancer

Question 29

CA-19-9

Answer 29

Panc Adenocarcinoma

Question 30

CA-125

Answer 30

Ovarian Cancer

Question 31

Calcitonin

Answer 31

Meudllary THyroid carcioma

Question 32

CEA

Answer 32

CarcinoEmbryonic Antigen. Colorectal, panc. Also in some gastric, breast and medullarythyroid carniomas

Question 33

S-100

Answer 33

Neural Crest origin (melanomas, Neural tuomr,schwannoams, Langerhan cell hstiocytosis)

Question 34

TRAP

Answer 34

Hairy cell luekmia