Oncogenes

Question 1

How is a proto-oncogene converted to an oncogene?

Answer 1

Through gain of function, mutation
Requires damage to only one allele

Question 2

ALK

Answer 2

Receptor tyrosine kinase
Lung adenocarcinoma

Question 3

EGFR (ERBB1)

Answer 3

Receptor tyrosine kinase
Lung adenocarcinoma

Question 4

HER2 (ERBB2)

Answer 4

Receptor tyrosine kinase
Breast and gastric carcinomas

Question 5

RET

Answer 5

Receptor tyrosine kinase
MEN2A/2B, medullary and papillary thyroid carcinoma, pheochromocytoma

Question 6

BCR_ABL

Answer 6

Non-receptor tyrosine kinase
CML, ALL

Question 7

JAK2

Answer 7

Non-receptor tyrosine kinase
Myeloproliferative neoplasms

Question 8

BRAF

Answer 8

Serine/threonine kinase
Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

Question 9

c-KIT

Answer 9

Cytokine receptor (CD117)
Gastrointestinal stromal tumor, mastocytosis

Question 10

MYCC (c-myc)

Answer 10

Transcription factor
Burkett lymphoma

Question 11

MYCN (N-myc)

Answer 11

Transcription factor
Neuroblastoma

Question 12

KRAS

Answer 12

RAS GTPase
Colorectal, lung, pancreatic cancer

Question 13

BCL-2

Answer 13

Anti-apoptotic molecule
Follicular and diffuse large B-cell lymphomas