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High Yield > Oncogenes > Flashcards

Oncogenes Flashcards

(27 cards)

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1
Q

BCR-ABL

A

Oncogene

Philadelphia Chromosome

Tyrosine Kinase

9-22

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2
Q

BCL-2

A

Oncogene

Follicular Lymphoma

Anti-apoptotoic molecule

14-18

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3
Q

BRAF

A

Oncogene

Melanoma

Serine/threonien Kinase

Papillary too

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4
Q

C-kit

A

Oncogene

Gastrointestinal stromal tumor (GIST)

Cytokine receptor for stem cell factor

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5
Q

c-myc

A

Oncogene

Burkitt Lymphoma (8-14)

Transcription Factor

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6
Q

HER2/neu

A

Oncogene

Breast, ovarian and gastric carcinomas

Tyrosine kinase

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7
Q

L-myc

A

Oncogene

Lung tumors

Transcription factor

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8
Q

N-myc

A

Oncogene

Neuroblastoma –> irregular, firm, crosses midline (unlike nephroblastoma)

Transcription factor

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9
Q

RAS

A

Oncogene

Colon, lung, pancreatic

GTPase

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10
Q

Ret

A

Oncogene

MEN2A/B
MCT, papiallary thyroid

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11
Q

APC

A

Tumorsuppressor

Colorectal (FAP)

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12
Q

BRCA1

A

Tumorsuppressor

Breast and ovarain

DNA repair

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13
Q

BRCA2

A

Tumorsuppressor

Breast and Ovarian (male too)

DNA repair

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14
Q

CPD4/SMAD4

A

Tumorsuppressor

Pancreatic

DPC –> deleted in Pancreatic cancer

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15
Q

DCC

A

Tumorsuppressor

Colon Cancer

DCC –> deleted in colon cancer

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16
Q

MEN1

Study These Flashcards
A

MEN type1

Tumorsuppressor

17
Q

NF1

Study These Flashcards
A

Tumorsuppressor

RAS GTPase activating protein (Neurofibromin)

18
Q

NF2

Study These Flashcards
A

Tumorsuppressor

Merlin (Shwannomin protein)

19
Q

p16

Study These Flashcards
A

Tumorsuppressor

Melanoma

Cyclin dependent kinase inhibitor

20
Q

p53

Study These Flashcards
A

Tumorsuppressor

Most cancers

Li-fraumeni –> SBLA Sarcoma, breast, lung, adrenal

21
Q

PTEN

Study These Flashcards
A

Tumorsuppressor

Breast, prostate, endometrial

22
Q

Rb

Study These Flashcards
A

Tumorsuppressor

Retinoblastoma, osteosarcoma

E7

Inhibits E2F

23
Q

TSC1

Study These Flashcards
A

Tumorsuppressor

Tuberosclerosis

Hamartin

24
Q

TSC2

Study These Flashcards
A

Tumorsuppressor

Tubero

Tuberin

25
VHL
Tumorsuppressor Inhibits HIF --> RCC (bilat), Hemangioblastomas in CNS, pheos
26
WT1
Tumorsuppressor Wilm's tumor (nephroblastoma) Smooth unilateral, doesn't cross midline (unlike neuroblastoma). WAGR
27
WT1
Tumorsuppressor Wilm's tumor (nephroblastoma) Smooth unilateral, doesn't cross midline (unlike neuroblastoma). WAGR

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