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Pathology > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

ALK

A

Receptor tyrosine kinase

Lung adenocarcinoma

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2
Q

BCR-ABL

A

Tyrosine kinase

CML/ALL

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3
Q

BCL-2

A

Antiapoptotic molecule

Follicular and diffuse large B cell lymphoma

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4
Q

BRAF

A

Serine/threonine kinase
Melanoma
Non-Hodgkin lymphoma
Papillary thyroid carcinoma

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5
Q

C-KIT

A

Cytokine receptor

GI stromal tumor (GIST)

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6
Q

C-MYC

A

Transcription factor

Burkitt lymphoma

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7
Q

HER2/neu

A

Receptor tyrosine kinase

Breast and gastric carcinomas

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8
Q

JAK2

A

Tyrosine kinase

Chronic myeloproliferative disorders

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9
Q

KRAS

A

GTPase

Colon cancer, lung cancer, pancreatic cancer

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10
Q

MYCL1

A

TF

Lung tumor

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11
Q

MYCN

A

TF

Neuroblastoma

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12
Q

RET

A

Receptor tyrosine kinase
MEN 2A/2B
Medullary thyroid cancer

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Pathology (5 decks)

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