Oncogenes and Associated Tumors

Question 1

PDGFB

Answer 1

Astrocytoma (glial cell), overexpression via autocrine loop, growth factor, platelet derived growth factor

Question 2

ERBB2 (HER2/neu)

Answer 2

Subset of breast carcinomas, epidermal growth factor receptor, amplification

Question 3

RET

Answer 3

MEN2A, MEN2B and sporadic

medullary carcinoma of thyroid, neural growth factor receptor, point mutation

Question 4

KIT

Answer 4

GI stromal tumor, stem cell growth factor receptor, point mutation

Question 5

RAS gene family

Answer 5

Carcinomas, melanoma and lymphoma, GTP binding protein, point mutation

Question 6

ABL

Answer 6

CML and some types of ALL, t(9;22) ABL-BCR (philly chromosome), tyrosine kinase

Question 7

c-MYC

Answer 7

Burkitt lymphoma

t(8;14) with IgH, transcription factor

Question 8

n-MYC

Answer 8

Neuroblastoma, transcription factor

Question 9

L-MYC

Answer 9

small cell lung carcinoma, transcription factor

Question 10

CCND1 (cyclin D1 gene)

Answer 10

Mantel cell lymphoma

t(11;14) with IgH (allows G1 to S)

Question 11

CDK4

Answer 11

Melanoma, glioblastoma, sarcoma

Question 12

p16

Answer 12

Melanoma

Question 13

Bcl2

Answer 13

Follicular Lymphoma

t(14;18)

Question 14

HGF (Hepatocyte Growth Factor)

Answer 14

Hepatocellular carcinoma, thyroid cancer

Question 15

Fibroblast growth factors, HST1 and FGF3

Answer 15

Osteosarcoma, stomach cancer, bladder cancer, breast cancer, melanoma

Question 16

ERBB1 (EFGR)

Answer 16

Adenocarcinoma of lung

Question 17

FLT3 (FMS-like tyrosine kinase 3)

Answer 17

leukemia

Question 18

ALK (ALK receptor- growth factor receptor)

Answer 18

Adenocarcinoma of lung, certain lymphomas and neuroblastoma

Question 19

BRAF (RAS signal transduction)

Answer 19

Melanomas, leukemias, colon carcinoma, others

Question 20

NOTCH1

Answer 20

Leukemias, lymphomas, breast carcinoma

Question 21

JAK2

Answer 21

Myeloproliferative Disorders

ALL

Question 22

TGF-alpha

Answer 22

astromcytoma