Oncogenes/Tumor Suppresors Flashcards
(25 cards)
ALK
Oncogene
Tyrosine kinase
Lung adenocarcinoma
BCR-ABL
Oncogene
Tyrosine kinase
CML, ALL
BCL-2
Oncogene
Anti-apoptotic
Follicular and tissue large B cell lymphoma
BRAF
Oncogene
Serine/threonine kinase
Melanoma non-Hodgkin lymphoma, papillary thyroid cancer
c-Kit
Oncogene
cytokine receptor
Gastrointestinal stromal tumor
c-Myc
Oncogene
Transcription factor
Burkitt lymphoma
Her2/neu (c-ERB2)
Oncogene
Receptor tyrosine kinase
Breast and gastric cancer
Jak2
Oncogene
Tyrosine kinase
Chronic myeloproliferative disorders
KRAS
Oncogene
GTPase
Colon cancer, lung cancer, pancreatic cancer
MYLC1
Oncogene
Transcription factor
Lung tumor
N-myc
Oncogene
Transcription factor
Neuroblastoma
RET
Oncogene
Receptor tyrosine kinase
MEN 2A, 2B, papillary thyroid cancer
APC
Tumor suppressor
Negative regulator of beta-catenin/WNT pathway
Colorectal cancer
BRCA
Tumor suppressor
DNA repair protein (homologous recombination)
Breast, ovarian, pancreatic cancer
CDKN2A
Tumor suppressor
p16, blocks G1 –> S transition
Melanoma, pancreatic
Rb
Tumor suppressor
Inhibits E2F - blocks G1 –> S transition
Retinoblastoma, osteosarcoma
Psammoma bodies
Papillary thyroid cancer
Serous cystoadenocarcinoma of ovary
Meningioma
Malignant mesothelioma
Elevated AFP
HCC Neural tube defects Endodermal sinus tumor Mixed germ cell tumor Ataxia-telengectasia [Low AFP - Down Syndrome]
CA 15-3/CA 27-20
Breast cancer
CEA
Colorectal, pancreatic cancer
S-100 Stain
Neural crest origin
Melanoma, schwannoma, Langhernas cell histiocytosis
Neurofilament
Neurons
Chromogranin and synaptophysin
Neuroendocrine cells
Desmin
muscle tumors
