oncogenes/tumor suppressor genes

Question 1

PDGF function

Answer 1

oncogene

growth factor

Question 2

PDGF disease association

Answer 2

astrocytoma and osteosarcoma

Question 3

HER2-neu (c-ERBB2) function

Answer 3

oncogene

growth factor receptor

Question 4

HER2-neu disease association

Answer 4

breast and ovarian cancers

Question 5

RAS function

Answer 5

oncogene

signal transduction molecule

Question 6

RAS disease association

Answer 6

bladder; colon; pancreatic and others

Question 7

ABL function

Answer 7

oncogene

signal transduction

Question 8

ABL disease association

Answer 8

leukemias

Question 9

BRAF function

Answer 9

oncogene

signal transduction molecule

Question 10

BRAF disease association

Answer 10

melanoma; colon; thyroid cancer

Question 11

MYC function

Answer 11

oncogene

transcription factor

Question 12

MYC disease association

Answer 12

C-MYC associated with Burkitt lymphoma, N-MYC associated with neuroblastoma

Question 13

cyclin D function

Answer 13

oncogene

cell cycle progression

Question 14

cyclin D disease association

Answer 14

multiple myeloma; breast and liver cancer

Question 15

Rb

Answer 15

tumor suppressor

retinoblastoma, breast, bladder, small cell lung CA, osteosarcoma

Question 16

p53

Answer 16

tumor suppressor
colon, breast, bladder lung, skin
found in 50% of all cancers

Question 17

NF-1

Answer 17

tumor suppressor

neurofibromatosis

Question 18

APC/beta-catenin

Answer 18

tumor suppressor

familial adenomatous polyposis (colon), hepatocellular carcinoma

Question 19

WT-1

Answer 19

tumor suppressor

wilms tumor, leukemias

Question 20

VHL

Answer 20

tumor suppressor

renal cancer, pheochromocytomas, CNS, hemangioblastomas