Oncogenes & Tumor supressor genes

Question 1

Oncogenes

Answer 1

1-hit gain of function (1 allele)

Question 2

Tumor supressor genes

Answer 2

2-hit loss of function (2 alleles)

Question 3

Lynch Syndrome

Answer 3

MSH2

MLH1

Question 4

Lung AdenoCa

Answer 4

ALK - Receptor tyrosine kinase

ONCO

Question 5

CML

ALL

Answer 5

BCR-ABL - Non receptor TK

ONCO

Question 6

Follicular and Diffuse Large B cell lymphoma

Answer 6

BCL-2 - Antiapoptotic

ONCO

Question 7

Melanoma
Non-Hodgkin Lymphoma
Papillary thyroid Ca
Hairy cell Leukemia

Answer 7

BRAF - Serine/threonine kinase

ONCO

Question 8

GI stromal tumor (GIST)

Answer 8

c-KIT - Cytokine receptor (Stem cell GF)

ONCO

Question 9

Burkitt Lymphoma

Answer 9

c-MYC - transcription factor (nuclear regulator)
t(8;14)
(ONCO)

Question 10

Breast and Gastric Ca

Answer 10

HER2/neu (c-erb82) - Receptor tyrosine kinase (epidermal growth factor receptor)
(ONCO)

Question 11

Chronic myeloproliferative disorders

Answer 11

JAK2 - Tyrosine kinase

ONCO

Question 12

Colon Ca
Lung Ca
Pancreatic Ca

Answer 12

KRAS - GTPase binding protein (point mutation)

ONCO

Question 13

Lung Tumor

Answer 13

L-myc - transcription factor

ONCO

Question 14

Neuroblastoma

Answer 14

N-myc -transcription factor

ONCO

Question 15

MEN 2A
MEN 2B
Papillary thyroid Ca
Pheochromocytoma

Answer 15

RET - receptor TK

ONCO

Question 16

Colorectal Ca (associated to FAP)

Answer 16

APC - Negative regulator of ß-catenin/WNT pathway

TSG

Question 17

Breast Ca
Ovarian Ca
Pancreatic Ca

Answer 17

BRCA1/BRCA2 - proteins

TSG

Question 18

Melanoma

Pancreatic Ca

Answer 18

CDKN2A - p16, blocks G1 –> S phase

TSG

Question 19

Colon Ca

Answer 19

DCC - Deleted in colon cancer

TSG

Question 20

Pancreatic Ca

Answer 20

SMAD4 (DPC4) - Deleted in pancreatin Ca

TSG

Question 21

MEN1

Answer 21

Menin

TSG

Question 22

Neurofibromatosis type 1

Answer 22

NF1 - Neurofibromin (Ras GTPase activating protein)

TSG

Question 23

Neurofibromatosis type 2

Answer 23

NF2 - Merlin (schwannomin) protein

TSG

Question 24

Prostate Ca
Breast Ca
Endometrial Ca

Answer 24

PTEN - Negative regulator of PI3k/AKT pathway

TSG

Question 25

Retinoblastoma | Osteosarcoma

Answer 25

Rb - Inhibits E2F; Blocks G1 --> S phase | TSG

Question 26

Most human Ca Li-fraumeni Syndrome SBLA Ca Syndrome: Sarcoma, Breast, Leukemia, Adrenal gland

Answer 26

TP53 - activates has p21; blocks G1 --> S phase | TSG

Question 27

Tuberous sclerosis

Answer 27

TSC1 - Hamartin protein TSC2- Tuberin protein (TSG)

Question 28

von-Hippel-Lindau

Answer 28

VHL - inhibits hypoxia-inducible factor 1a | TSG

Question 29

Wilms Tumor

Answer 29

WT1 - Urogenital development transcription factor | TSG

Question 30

Lynch Syndrome can cause?

Answer 30

Colon Ca Endometrial Ca Ovarian Ca Skin Ca